EC Number   |
Application |
Reference |
|---|
   2.7.11.25 | analysis |
development of a protein chip consisting of a silicone elastomer microwell array with recombinant enzyme covalently attached to the wells via a 3-glycidoxypropyltrimethoxysilane crosslinker for large scale activity assay, overview |
662926 |
| 2.7.11.25 | analysis |
proline cis-trans isomerization of MEKK3 PB1 of the Gln38-Pro39 bond, first case of structural heterogeneity within PB1 domains, major difference between both isomers in the Pro39 region. Residues Gly37-Leu40 form a type VIb beta-turn in the cis conformation, whereas no obvious character of beta-turn is observed in the trans conformation. Internal motions in the beta3/beta4-turn on a microsecond-millisecond time scale |
678242 |
| 2.7.11.25 | medicine |
cleavage of MEKK1 and caspase-3 is highly increased in adenovirus-mediated overexpression of melanoma differentiation-associated gene-7treated H1299-dnIkappaBalpha tumors than in adenovirus-mediated overexpression of melanoma differentiation-associated gene-7treated H1299-Neo tumors |
681872 |
| 2.7.11.25 | medicine |
GCKR facilitates both canonical and noncanonical Wnt signaling in B lymphocytes |
-, 681911 |
| 2.7.11.25 | medicine |
gene amplification and corresponding increased Tpl-2 expression in some human breast cancers |
682213 |
| 2.7.11.25 | medicine |
IL-1beta through MEKK1 inhibits human insulin gene transcription and does so, at least in part, by decreasing MafA transcriptional activity at the RIPE3b control element. Since inappropriate insulin biosynthesis contributes to beta cell dysfunction, inhibition of MEKK1 may decelerate or prevent progression from a prediabetic state to diabetes mellitus |
679458 |
| 2.7.11.25 | medicine |
MEKK4 is a critical signaling molecule during cardiovascular development, plays an important role in cardiac cushion morphogenesis, kinase activity of MEKK4 is essential, but not sufficient, to support developmental epithelial to mesenchymal transformation |
679428 |
| 2.7.11.25 | medicine |
role in epithelial wound healing, transmits wound signals, leading to the transcriptional activation of genes involved in ECM homeostasis, epithelial cell migration, and wound reepithelialization |
681828 |
| 2.7.11.25 | medicine |
stress kinase MEKK1-induced MMP-1 expression in human arthritis-affected synovial cells is mediated, in large part, by c/EBPbeta (NF-kappaBp65) promoter transactivation |
680667 |
| 2.7.11.25 | medicine |
ZPK/DLK can become a strategic therapeutic target in motor neuron diseases in which aberrant activation of the apoptogenic cascade is involved |
740889 |
