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Literature summary for 2.7.11.25 extracted from

  • Oida, Y.; Gopalan, B.; Miyahara, R.; Branch, C.D.; Chiao, P.; Chada, S.; Ramesh, R.
    Inhibition of nuclear factor-kappaB augments antitumor activity of adenovirus-mediated melanoma differentiation-associated gene-7 against lung cancer cells via mitogen-activated protein kinase kinase kinase 1 activation (2007), Mol. Cancer Ther., 6, 1440-1449.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information treatment of H1299-dnIkappaBalpha tumors with adenovirus-mediated overexpression of melanoma differentiation-associated gene-7 shows increased MEKK1 cleavage and activation of caspase-3, induces NF-kappaB expression in lung tumor cells in a time-dependent manner. NF-kappaB activation by overexpressed dnIkappaBalpha enhances the antitumor activity of melanoma differentiation-associated gene-7 Homo sapiens

Application

Application Comment Organism
medicine cleavage of MEKK1 and caspase-3 is highly increased in adenovirus-mediated overexpression of melanoma differentiation-associated gene-7–treated H1299-dnIkappaBalpha tumors than in adenovirus-mediated overexpression of melanoma differentiation-associated gene-7–treated H1299-Neo tumors Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
siRNA MEKK1-specific siRNA inhibits with adenovirus-mediated overexpression of melanoma differentiation-associated gene-7-mediated MEKK1 cleavage Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
lung cancer cell line
-
 Homo sapiens
-
additional information H1299 cell, MRC-9 cell Homo sapiens
-
WI-38 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
MEKK1
-
 Homo sapiens
mitogen-activated protein kinase kinase kinase 1
-
 Homo sapiens