Reference on EC 4.1.1.4 - acetoacetate decarboxylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yan, R.T.; Zhu, C.X.; Golemboski, C.; Chen, J.S.
Expression of solvent-forming enzymes and onset of solvent production in batch cultures of Clostridium beijerinckii
Appl. Environ. Microbiol.
54
642-648
1988
Clostridium beijerinckii
Kimura, Y.; Yasuda, N.; Tanigaki-Nagae, H.; Nakabayashi, T.; Matsunga, H.M; Kimura, M.; Matsuoka, A.
Acetoacetate decarboxylase and a peptide with similar activity produced by Bacillus polymyxa
Agric. Biol. Chem.
50
2509-2516
1986
Paenibacillus polymyxa, Paenibacillus polymyxa A-57
-
Rozzel, J.D.; Benner, S.A.
Stereochemical imperative in enzymic decarboxylation. Stereochemical course of the decarboxylation catalyzed by acetoacetate decarboxylase
J. Am. Chem. Soc.
106
4937-4941
1984
Clostridium acetobutylicum
-
Benner, S.A.; Rozzel, J.D.
Stereospecificity and stereochemical infidelity of acetoacetate decarboxylase (AAD)
J. Am. Chem. Soc.
103
993-994
1981
Clostridium acetobutylicum
-
Kluger, R.; Nakaoka, K.
Inhibition of acetoacetate decarboxylase by ketophosphonates. Structural and dynamic probes of the active site
Biochemistry
13
910-914
1974
Clostridium acetobutylicum
Fridovich, I.
Acetoacetate decarboxylase
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
6
255-270
1972
Clostridium acetobutylicum
-
Autor, A.P.; Fridovich, I.
The thermal inactivation of acetoacetate decarboxylase
J. Biol. Chem.
245
5223-5227
1970
Clostridium acetobutylicum
Autor, A.P.; Fridovich, I.
The interactions of acetoacetate decarboxylase with carbonyl compounds, hydrogen cyanide, and an organic mercurial
J. Biol. Chem.
245
5214-5222
1970
Clostridium acetobutylicum
Westheimer, F.H.
Acetoacetate decarboxylase from Clostridium acetobutylicum
Methods Enzymol.
14
231-241
1969
Clostridium acetobutylicum
-
Tagaki, W.; Guthrie, J.P.; Westheimer, F.H.
Acetoacetate decarboxylase. Reaction with acetopyruvate
Biochemistry
7
905-913
1968
Clostridium acetobutylicum
Tagaki, W.; Westheimer, F.H.
Acetoacetate decarboxylase. Catalysis of hydrogen-deuterium exchange in acetone
Biochemistry
7
901-905
1968
Clostridium acetobutylicum
Tagaki, W.; Westheimer, F.H.
Acetoacetate decarboxylase. The molecular weight of the enzyme and subunits
Biochemistry
7
895-900
1968
Clostridium acetobutylicum
Tagaki, W.; Westheimer, F.H.
Acetoacetate decarboxylase. Reassociation of subunits
Biochemistry
7
891-894
1968
Clostridium acetobutylicum
Fridovich, I.
A study of the interaction of acetoacetic decarboxylase with several inhibitors
J. Biol. Chem.
243
1043-1051
1968
Clostridium acetobutylicum
Neece, M.S.; Fridovich, I.
Acetoacetic decarboxylase. Activation by heat
J. Biol. Chem.
242
2939-2944
1967
Clostridium acetobutylicum
O'Leary, M.H.; Westheimer, F.H.
Acetoacetate decarboxylase. Selective acetylation of the enzyme
Biochemistry
7
913-919
1968
Clostridium acetobutylicum
Ballongue, J.; Amine, J.; Masion, E.; Petitdemange, H.; Gay, R.
Induction of acetoacetate decarboxylase in Clostridium acetobutylicum
FEMS Microbiol. Lett.
29
273-277
1985
Clostridium acetobutylicum
-
Gerischer, U.; Durre, P.
Cloning, sequencing, and molecular analysis of the acetoacetate decarboxylase gene region from Clostridium acetobutylicum
J. Bacteriol.
172
6907-6918
1990
BRENDA: Clostridium acetobutylicum
Textmining: Clostridium acetobutylicum ATCC 824, Escherichia coli, Bacillus subtilis
Highbarger, L.A.; Gerlt, J.A.; Kenyon, G.L.
Mechanism of the reaction catalyzed by acetoacetate decarboxylase. Importance of lysine 116 in determining the pKa of the active-site lysine 115
Biochemistry
35
41-46
1996
Clostridium acetobutylicum
Petersen, D.J.; Bennett, G.N.
Purification of acetoacetate decarboxylase from Clostridium acetobutylicum ATCC 824 and cloning of the acetoacetate decarboxylase gene in Escherichia coli
Appl. Environ. Microbiol.
56
3491-3498
1990
BRENDA: Clostridium acetobutylicum
Textmining: Escherichia coli, Clostridium acetobutylicum ATCC 824, Escherichia virus Lambda
Matiasek M.G.; Choudhury K.; Nemecek-Marshall, M.; Fall, R.
Volatile ketone formation in bacteria: release of 3-oxopentanoate by soil pseudomonads during growth on heptanoate
Curr. Microbiol.
42
276-281
2001
BRENDA: Paenibacillus polymyxa, Pseudomonas putida
Textmining: Bacteria, Pseudomonas fluorescens, Pseudomonas chlororaphis subsp. aureofaciens
Ravagnani, A.; Jennert, K.C.B.; Steiner, E.; Grunberg, R.; Jefferies, J.R.; Wilkinson, S.R.; Young, D.I.; Tidswell, E.C.; Brown, D.P.; Youngman, P.; Morris, J.G.; Young M.
Spo0A directly controls the switch from acid to solvent production in solvent-forming clostridia
Mol. Microbiol.
37
1172-1185
2000
BRENDA: Clostridium acetobutylicum, Clostridium beijerinckii, Ruminiclostridium cellulolyticum, Clostridium beijerinckii NCIMB 8052, Clostridium beijerinckii AA243
Textmining: Clostridia, Bacillus, Bacillus subtilis, Clostridium, Simpsonaias
Hanai, T.; Atsumi, S.; Liao, J.C.
Engineered synthetic pathway for isopropanol production in Escherichia coli
Appl. Environ. Microbiol.
73
7814-7818
2007
Clostridium acetobutylicum
Jojima, T.; Inui, M.; Yukawa, H.
Production of isopropanol by metabolically engineered Escherichia coli
Appl. Microbiol. Biotechnol.
77
1219-1224
2008
BRENDA: Clostridium acetobutylicum (P23670)
Textmining: Escherichia coli JM109, Clostridium beijerinckii, Clostridium acetobutylicum ATCC 824, Escherichia coli
Jiang, Y.; Xu, C.; Dong, F.; Yang, Y.; Jiang, W.; Yang, S.
Disruption of the acetoacetate decarboxylase gene in solvent-producing Clostridium acetobutylicum increases the butanol ratio
Metab. Eng.
11
284-291
2009
BRENDA: Clostridium acetobutylicum, Clostridium acetobutylicum EA 2018
Textmining: Clostridium, Electron
Ho, M.C.; Menetret, J.F.; Tsuruta, H.; Allen, K.N.
The origin of the electrostatic perturbation in acetoacetate decarboxylase
Nature
459
393-397
2009
Clostridium acetobutylicum (P23670), Chromobacterium violaceum (Q7NSA6)
Ishikita, H.
Origin of the pKa shift of the catalytic lysine in acetoacetate decarboxylase
FEBS Lett.
584
3464-3468
2010
Clostridium acetobutylicum (P23670), Chromobacterium violaceum (Q7NSA6)
Lehmann, D.; Radomski, N.; Luetke-Eversloh, T.
New insights into the butyric acid metabolism of Clostridium acetobutylicum
Appl. Microbiol. Biotechnol.
96
1325-1339
2012
Clostridium acetobutylicum
Han, B.; Gopalan, V.; Ezeji, T.C.
Acetone production in solventogenic Clostridium species: new insights from non-enzymatic decarboxylation of acetoacetate
Appl. Microbiol. Biotechnol.
91
565-576
2011
BRENDA: Clostridium beijerinckii (A6M020), Clostridium acetobutylicum (P23670), Clostridium beijerinckii NCIMB 8052 (A6M020), Clostridium beijerinckii NCIMB 8052
Textmining: Clostridium
Min, K.; Kim, S.; Yum, T.; Kim, Y.; Sang, B.I.; Um, Y.
Conversion of levulinic acid to 2-butanone by acetoacetate decarboxylase from Clostridium acetobutylicum
Appl. Microbiol. Biotechnol.
97
5627-5634
2013
BRENDA: Clostridium acetobutylicum (P23670), Clostridium acetobutylicum
Textmining: Escherichia coli
Shaw, A.; Miller, B.; Rogers, S.; Kenealy, W.; Meola, A.; Bhandiwad, A.; Sillers, W.; Shikhare, I.; Hogsett, D.; Herring, C.
Anaerobic detoxification of acetic acid in a thermophilic ethanologen
Biotechnol. Biofuels
8
75
2015
Thermoanaerobacterium saccharolyticum
Hoenicke, D.; Luetke-Eversloh, T.; Liu, Z.; Lehmann, D.; Liebl, W.; Ehrenreich, A.
Chemostat cultivation and transcriptional analyses of Clostridium acetobutylicum mutants with defects in the acid and acetone biosynthetic pathways
Appl. Microbiol. Biotechnol.
98
9777-9794
2014
Clostridium acetobutylicum
Liu, Y.; Patel, A.; Burger, S.; Ayers, P.
Benchmarking pKa prediction methods for Lys115 in acetoacetate decarboxylase
J. Mol. Model.
23
155
2017
Clostridium acetobutylicum (P23670)
Koorevaar, G; Van Stekelenburg, GJ
Mammalian acetoacetate decarboxylase activity. Its distribution in subfractions of human albumin and occurrence in various tissues of the rat.
Clin Chim Acta
71
173-83
1976
Homo sapiens, Rattus
Janati-Idrissi, R; Junelles, AM; Petitdemange, H; Gay, R
Regulation of coenzyme A transferase and acetoacetate decarboxylase activities in Clostridium acetobutylicum.
Ann Inst Pasteur Microbiol
139
683-8
0
Clostridium acetobutylicum
López-Soriano, FJ; Argilés, JM
Rat acetoacetate decarboxylase: its role in the disposal of 4C-ketone bodies by the fetus.
Horm Metab Res
18
446-9
1986
Rattus
López-Soriano, FJ; Alemany, M; Argilés, JM
Rat acetoacetic acid decarboxylase inhibition by acetone.
Int J Biochem
17
1271-3
1985
Rattus, Mammalia
van Stekelenburg, GJ; Koorevaar, G
Evidence for the existence of mammalian acetoacetate decarboxylase: with special reference to human blood serum.
Clin Chim Acta
39
191-9
1972
Homo sapiens
Mueller, LS; Hoppe, RW; Ochsenwald, JM; Berndt, RT; Severin, GB; Schwabacher, AW; Silvaggi, NR
Sbi00515, a Protein of Unknown Function from Streptomyces bingchenggensis, Highlights the Functional Versatility of the Acetoacetate Decarboxylase Scaffold.
Biochemistry
54
3978-88
2015
Streptomyces bingchenggensis, Streptomyces hygroscopicus, Streptomyces bingchenggensis BCW-1, bacterium
Zeldes, BM; Straub, CT; Otten, JK; Adams, MWW; Kelly, RM
A synthetic enzymatic pathway for extremely thermophilic acetone production based on the unexpectedly thermostable acetoacetate decarboxylase from Clostridium acetobutylicum.
Biotechnol Bioeng
2018
Clostridium acetobutylicum, bacterium
Yang, B; Gao, H; Qi, H; Chen, Y; Ross, RP; Stanton, C; Zhao, J; Zhang, H; Chen, H; Chen, W
Linoleate Isomerase Complex Contributes to Metabolism and Remission of DSS-Induced Colitis in Mice of Lactobacillus plantarum ZS2058.
J Agric Food Chem
69
8160-8171
2021
Lactiplantibacillus plantarum
Nair, RV; Papoutsakis, ET
Expression of plasmid-encoded aad in Clostridium acetobutylicum M5 restores vigorous butanol production.
J Bacteriol
176
5843-6
1994
Clostridium acetobutylicum ATCC 824
Chen, CK; Blaschek, HP
Examination of physiological and molecular factors involved in enhanced solvent production by clostridium beijerinckii BA101
Appl Environ Microbiol
65
2269-71
1999
Clostridium beijerinckii
Janati-Idrissi, R; Junelles, AM; el Kanouni, A; Petitdemange, H; Gay, R
Pyruvate fermentation by Clostridium acetobutylicum.
Biochem Cell Biol
67
735-9
1989
Clostridium acetobutylicum, Clostridium acetobutylicum ATCC 824
Mermelstein, LD; Welker, NE; Bennett, GN; Papoutsakis, ET
Expression of cloned homologous fermentative genes in Clostridium acetobutylicum ATCC 824.
Biotechnology (N Y)
10
190-5
1992
Clostridium acetobutylicum ATCC 824, Escherichia coli, Bacillus subtilis, Clostridium acetobutylicum, plasmids
Gerischer, U; Dürre, P
mRNA analysis of the adc gene region of Clostridium acetobutylicum during the shift to solventogenesis.
J Bacteriol
174
426-33
1992
Clostridium acetobutylicum, Escherichia coli, Firmicutes, Bacillus subtilis
Dürre, P; Fischer, RJ; Kuhn, A; Lorenz, K; Schreiber, W; Stürzenhofecker, B; Ullmann, S; Winzer, K; Sauer, U
Solventogenic enzymes of Clostridium acetobutylicum: catalytic properties, genetic organization, and transcriptional regulation.
FEMS Microbiol Rev
17
251-62
1995
Clostridium acetobutylicum
Petersen, DJ; Cary, JW; Vanderleyden, J; Bennett, GN
Sequence and arrangement of genes encoding enzymes of the acetone-production pathway of Clostridium acetobutylicum ATCC824.
Gene
123
93-7
1993
Artemisia maritima subsp. incana, Terminator
Bermejo, LL; Welker, NE; Papoutsakis, ET
Expression of Clostridium acetobutylicum ATCC 824 genes in Escherichia coli for acetone production and acetate detoxification.
Appl Environ Microbiol
64
1079-85
1998
Escherichia coli, Clostridium acetobutylicum ATCC 824
Dürre, P; Böhringer, M; Nakotte, S; Schaffer, S; Thormann, K; Zickner, B
Transcriptional regulation of solventogenesis in Clostridium acetobutylicum.
J Mol Microbiol Biotechnol
4
295-300
2002
Argynnis pandora
Berezina, OV; Brandt, A; Yarotsky, S; Schwarz, WH; Zverlov, VV
Isolation of a new butanol-producing Clostridium strain: high level of hemicellulosic activity and structure of solventogenesis genes of a new Clostridium saccharobutylicum isolate.
Syst Appl Microbiol
32
449-59
2009
Clostridium saccharobutylicum, Escherichia coli
Collas, F; Kuit, W; Clement, B; Marchal, R; Lopez-Contreras, AM; Monot, F
Simultaneous production of isopropanol, butanol, ethanol and 2,3-butanediol by Clostridium acetobutylicum ATCC 824 engineered strains.
AMB Express
2
45
2012
Clostridium acetobutylicum
Cooksley, CM; Zhang, Y; Wang, H; Redl, S; Winzer, K; Minton, NP
Targeted mutagenesis of the Clostridium acetobutylicum Acetone-Butanol-Ethanol fermentation pathway.
Metab Eng
2012
Clostridium acetobutylicum
Tamakawa, H; Mita, T; Yokoyama, A; Ikushima, S; Yoshida, S
Metabolic engineering of Candida utilis for isopropanol production.
Appl Microbiol Biotechnol
97
6231-9
2013
Cyberlindnera jadinii, Clostridium beijerinckii NRRL B-593, Saccharomyces cerevisiae, Clostridium acetobutylicum ATCC 824
Burroughs, AM; Hoppe, RW; Goebel, NC; Sayyed, BH; Voegtline, TJ; Schwabacher, AW; Zabriskie, TM; Silvaggi, NR
Structural and functional characterization of MppR, an enduracididine biosynthetic enzyme from streptomyces hygroscopicus: functional diversity in the acetoacetate decarboxylase-like superfamily.
Biochemistry
52
4492-506
2013
Staphylococcus aureus, Streptomyces hygroscopicus
Kusakabe, T; Tatsuke, T; Tsuruno, K; Hirokawa, Y; Atsumi, S; Liao, JC; Hanai, T
Engineering a synthetic pathway in cyanobacteria for isopropanol production directly from carbon dioxide and light.
Metab Eng
2013
Synechococcus elongatus
Grousseau, E; Lu, J; Gorret, N; Guillouet, SE; Sinskey, AJ
Isopropanol production with engineered Cupriavidus necator as bioproduction platform.
Appl Microbiol Biotechnol
2014
Cupriavidus necator, Clostridium
Pan, H; Zhang, L; Li, X; Guo, D
Biosynthesis of the fatty acid isopropyl esters by engineered Escherichia coli.
Enzyme Microb Technol
102
49-52
2017
Escherichia coli, Clostridium acetobutylicum, Clostridium beijerinckii, Acinetobacter baylyi ADP1
Mydy, LS; Mashhadi, Z; Knight, TW; Fenske, T; Hagemann, T; Hoppe, RW; Han, L; Miller, TR; Schwabacher, AW; Silvaggi, NR
Swit_4259, an acetoacetate decarboxylase-like enzyme from Sphingomonas wittichii RW1.
Acta Crystallogr F Struct Biol Commun
73
672-681
2017
Sphingomonas wittichii RW1, Sphingomonas wittichii, bacterium
Yang, H; Huang, B; Lai, N; Gu, Y; Li, Z; Ye, Q; Wu, H
Metabolic engineering of Escherichia coli carrying the hybrid acetone-biosynthesis pathway for efficient acetone biosynthesis from acetate.
Microb Cell Fact
18
6
2019
Clostridium acetobutylicum, Escherichia coli str. K-12 substr. MG1655, Escherichia coli
Streett, HE; Kalis, KM; Papoutsakis, ET
A Strongly Fluorescing Anaerobic Reporter and Protein-Tagging System for Clostridium Organisms Based on the Fluorescence-Activating and Absorption-Shifting Tag Protein (FAST).
Appl Environ Microbiol
85
2019
Clostridium acetobutylicum
Yang, B; Chen, H; Gao, H; Ren, Q; Zhang, H; Chen, W
Genetic determinates for conjugated linolenic acid production in Lactobacillus plantarum ZS2058.
J Appl Microbiol
128
191-201
2020
Escherichia coli
Liu, XX; Xiong, ZQ; Wang, GQ; Wang, LF; Xia, YJ; Song, X; Ai, LZ
LysR Family Regulator LttR Controls Production of Conjugated Linoleic Acid in Lactobacillus plantarum by Directly Activating the cla Operon.
Appl Environ Microbiol
87
2021
Lactiplantibacillus plantarum
Flaiz, M; Ludwig, G; Bengelsdorf, FR; Drre, P
Production of the biocommodities butanol and acetone from methanol with fluorescent FAST-tagged proteins using metabolically engineered strains of Eubacterium limosum.
Biotechnol Biofuels
14
117
2021
Eubacterium limosum
Aziz, T; Sarwar, A; Ud Din, J; Al Dalali, S; Khan, AA; Din, ZU; Yang, Z
Biotransformation of linoleic acid into different metabolites by food derived Lactobacillus plantarum 12-3 and in silico characterization of relevant reactions.
Food Res Int
147
110470
2021
Lactiplantibacillus plantarum
Subagyo, DCH; Shimizu, R; Orita, I; Fukui, T
Isopropanol production with reutilization of glucose-derived CO2 by engineered Ralstonia eutropha.
J Biosci Bioeng
2021
Clostridia
Kimura, M; Kobayashi, K; Matsuoka, A; Hayashi, K; Kimura, Y
Head-space gas-chromatographic determination of 3-hydroxybutyrate in plasma after enzymic reactions, and the relationship among the three ketone bodies.
Clin Chem
31
596-8
1985
Homo sapiens
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