Cloned (Comment) | Organism |
---|---|
gene aadc encoded in the sol operon, cloning of gene fragments aadc358-1 and aadc358-2 in Escherichia coli strain DH5alpha, expression as GFP-tagged enzyme | Clostridium beijerinckii |
gene aadc, cloning in Escherichia coli strain DH5alpha, expression as GFP-tagged enzyme | Clostridium acetobutylicum |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of an aadc deletion mutant, the mutant produces a maximum acetone concentration comparable to that produced by wild-type. Non-enzymatic decarboxylation of acetoacetate in vitro, under conditions similar to in vivo acetone-butanol-ethanol fermentation, produces 1.3 to 5.2 g/L acetone between pH 4.0-6.5 and explains why various knock-out and knockdown strategies designed to disrupt aadc in solventogenic Clostridium species do not eliminate acetone production during acetone-butanol-ethanol fermentation | Clostridium beijerinckii |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetoacetate + H+ | Clostridium acetobutylicum | - |
acetone + CO2 | - |
? | |
acetoacetate + H+ | Clostridium beijerinckii | - |
acetone + CO2 | - |
? | |
acetoacetate + H+ | Clostridium beijerinckii NCIMB 8052 | - |
acetone + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Clostridium acetobutylicum | P23670 | gene aadc | - |
Clostridium beijerinckii | A6M020 | gene aadc | - |
Clostridium beijerinckii NCIMB 8052 | A6M020 | gene aadc | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetoacetate + H+ | - |
Clostridium acetobutylicum | acetone + CO2 | - |
? | |
acetoacetate + H+ | - |
Clostridium beijerinckii | acetone + CO2 | - |
? | |
acetoacetate + H+ | the AADC activity relies on measurement of CO2 produced as a result of AADC-catalyzed decarboxylation of acetoacetate | Clostridium acetobutylicum | acetone + CO2 | - |
? | |
acetoacetate + H+ | the AADC activity relies on measurement of CO2 produced as a result of AADC-catalyzed decarboxylation of acetoacetate | Clostridium beijerinckii | acetone + CO2 | - |
? | |
acetoacetate + H+ | - |
Clostridium beijerinckii NCIMB 8052 | acetone + CO2 | - |
? | |
acetoacetate + H+ | the AADC activity relies on measurement of CO2 produced as a result of AADC-catalyzed decarboxylation of acetoacetate | Clostridium beijerinckii NCIMB 8052 | acetone + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AADC | - |
Clostridium acetobutylicum |
AADC | - |
Clostridium beijerinckii |
General Information | Comment | Organism |
---|---|---|
physiological function | enzyme AADC-catalyzed decarboxylation of acetoacetate is not the sole means for acetone generation | Clostridium beijerinckii |