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(-)-epigallocatechin gallate
-
5-(3,4,5-trihydroxyphenyl) 4-hydroxyvaleric acid
-
5-(3,4,5-trihydroxyphenyl)-gamma-valerolactone
the metabolite has a hypotensive effect in vivo
5-(3,5-dihydroxyphenyl) 4-hydroxyvaleric acid
-
5-(3,5-dihydroxyphenyl)-gamma-valerolactone
the metabolite has a hypotensive effect in vivo
SPB1
Bacillus subtilis crude lipopeptide biosurfactant, the biosurfactant displays a potent inhibition of ACE activity in vitro, IC50 is 1.37 mg/ml
-
15B2
-
an inhibitor isolated from the culture broth of Actinomadura sp. No. 937ZE-1
aminoethyl-chitin
-
with 10%, 50%, and 90% deacetylation
benzoyl-NHCOCH2CH(COOH)-Ala-Pro-OH
-
-
benzoyl-NHCOCH2CH(COOH)-Trp-Pro-OH
-
-
bradykinin potentating factor nonapeptide
-
-
-
bradykinin potentiator B
-
-
bradykinin-potentiator B
-
-
bradykinin-potentiator C
-
-
chitooligosaccharide derivatives
-
i.e. COS, chitosan derivatives, polycationic polymers comprised principally of glucosamine units, generated via either chemical or enzymatic hydrolysis of chitosan. ACE inhibitory activity of hetero-COS, derived from crab chitin, is dependent on the degree of deacetylation of chitosan
-
chitosan trimer
-
effective in lowering blood pressure
Co2+
-
testicular enzyme is inhibited, lung enzyme not
D-mannitol
-
antihypertensive effect in spontaneously hypertensive rats by oral administration
dexamethasone
-
markedly inhibits the plasma extravasion in the tracheal mucosa produced by substance P. The simultanous inhibition of neutral endopeptidase and angiotensin converting enzyme completely reverses the effect of dexamethasone on substance P-induced extravasion
dieckol
-
deribed from Ecklonia stolonifera
eckol
-
derived from Ecklonia stolonifera
enalaprilat
-
inhibits ACE and the bradykinin degradation in vivo, which is reversed by insulin
ESIINF
-
the inhibitor produces an acute blood-pressure-lowering effect in spontaneously hypertensive rats upon a single oral administration
Gly-L-Ala-Hyp-Gly-L-Leu-Hyp-Gly-L-Pro
-
highest ACE-inhibitory activity
Gly-L-Ala-Hyp-Gly-L-Pro-L-Ala-Gly-L-Pro-Gly-Gly-L-Ile-Hyp-Gly-L-Glu-L-Arg-Gly
-
-
Gly-L-Ile-Hyp-Gly-L-Glu-L-Arg-Gly-L-Pro-L-Val-Gly-L-Pro-L-Ser-Gly
-
-
Gly-L-Leu-Hyp-Gly-L-Ser-L-Arg-Gly-L-Glu-L-Arg-Gly-L-Leu-Hyp-Gly
-
-
Gly-Phe-Hyp-Gly-Thr-Hyp-Gly-Leu-Hyp-Gly-Phe
-
inhibitory peptide derived from chicken breast muscle possesses hypotensive activity for spontaneously hypertensive rats
inhibitory peptides from rice dreg hydrolysate
-
significant antihypertensive action and no other side effects by oral administration in spontaneous hypertension rats
-
isorhamnetin-3-beta-glucopyranoside
-
IC50: 0.4089 mM
kaempferol
-
dose-dependent inhibition, 46% inhibition at 0.1 mM
kaempferol-3-alpha-arabinopyranoside
-
IC50: 0.3928 mM
KRQKYDI
-
competitive inhibitor, the strongest inhibitor among reported troponin-originated peptides. The inhibhitor is slowly hydrolyzed by treatment with angiotensin I-converting enzyme. When KRQKYDI is administered orally to spontaneously hypertensive rats at a dose of 10 mg/kg, a temporary antihypertensive activity is observed at 3 and 6 h after administration
L-681,176
-
purification of the inhibitor found in the culture filtrate of Streptomyces sp. MA 5143
Leu-Gln-Pro
-
competitive
Leu-Lys-Tyr
-
competitive
Leu-Val-Tyr
-
competitive
N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-L-proline
N-[(S)-1-Carboxy-3-phenylpropyl]-L-Ala-L-Pro
-
-
NaCl
-
concentration dependent inhibition of hippuryl-His-Leu between 0 and 100 mM
peimisine
-
IC50: 0.5265 mM
perindoprilat
-
strong inhibitor
phlorofucofuroeckol A
-
derived from Ecklonia stolonifera
phlorotannins
-
e.g. from Ahnfeltiopsis flabelliformis, Ecklonia cava, Ecklonia stolonifera, Pelvetia siliqousa, and Undaria pinnatifida, phenolic compounds formed by the polymerization of phloroglucinol or defined as 1,3,5-trihydroxybenzene monomer units and biosynthesized through the acetate-malonate pathway. They are highly hydrophilic components with a wide range of molecular sizes ranging between 126-650 kDa. A closed ring dibenzo-1,4-dioxin moiety may be crucial for ACE inhibitory effects
-
quercetin 3-O-alpha-(6''-p-coumaroylglucosyl-beta -1,2-rhamnoside)
-
IC50: 0.351 mM
quercetin-3-beta-glucopyranoside
-
IC50: 0.7088 mM
quercetin-3-O-alpha-(6''-caffeoylglucosyl-beta-1,2-rhamnoside)
-
IC50: 0.1589 mM
sardine peptide
-
a protein hydrolysate derived from muscles of sardines, inhibits in vivo and reduces the blood glucose level, but not the plasma insulin level
-
Teprotide
-
i.e. SQ 20881
trandolapril
-
the angiotensin-converting enzyme inhibitor has no significant effect on apoptosis induced via endotoxic shock with Escherichia coli lipopolysaccharides
Trp-Pro-Glu-Ala-Ala-Glu-Leu-Met-Met-Glu-Val-Asp-Pro
-
noncompetitive inhibitor.The peptide has an antihypertensive effect according to the time-course measurement after oral administration to spontaneously hypertensive rats. Maximal reduction is detected 3 h after oral administration at a dose of 10 mg/kg of body weight
Val-Lys-Lys-Val-Leu-Gly-Asn-Pro
-
the angiotensin-I converting enzyme inhibitory peptide derived from porcine skeletal muscle myosin is a noncompetitive inhibitor that is slowly hydrolyzed by angiotensin-I converting enzyme. At the dose of 10 mg/kg, this peptide shows antihypertensive activity after a maximum of 3 h of administration
verticine
-
IC50: 0.3128 mM
verticinone
-
IC50: 0.165 mM
YRGGLEPINF
-
the inhibitor produces an acute blood-pressure-lowering effect in spontaneously hypertensive rats upon a single oral administration
captopril
-
-
captopril
-
i.e. SQ 14225
captopril
-
lipophilic ACE inhibitors quinapril, enalapril, and captopril increase the survival and lifetime of rats with experimental chronic heart failure
captopril
-
plasma angiotensin converting enzyme inhibitors
captopril
-
the anngiotensin converting enzyme inhibitor captopril modifies conditioned place preference induced by morphine and morphine withdrawal signs in rats
captopril
-
ACE inhibition during pregnancy and lactation in adult offspring rats induces behavioural changes, e.g. in the open field test, overview
captopril
-
inhibits in vivo and reduces the blood glucose level, but not the plasma insulin level
captopril
-
synthetic ACE inhibitor and antihypertensive drug
enalapril
-
-
enalapril
-
acute angiotensin-converting enzyme inhibition evokes bradykinin-induced sympathetic activation in diabetic rats
enalapril
-
lipophilic ACE inhibitors quinapril, enalapril, and captopril increase the survival and lifetime of rats with experimental chronic heart failure
enalapril
-
plasma angiotensin converting enzyme inhibitors
enalapril
-
reduces the liver tissue transforming growth factor beta-1 and has an ameliorating effect on the fibrosis markers transforming growth factor beta-1 and matrix metalloproteinase-2. Enalapril does not affect the process of liver fibrosis at all (induced in rats by bile-duct ligation)
enalapril
-
the angiotensin-converting enzyme inhibitor has no significant effect on apoptosis induced via endotoxic shock with Escherichia coli lipopolysaccharides
genistein
-
0.003-0.3 mM genistein decreases the angiotensin-converting enzyme activity in blood plasma in a concentration-dependent manner
genistein
-
the isoflavone inhibits ACE in plasma and alters the vascular responses to angiotensin I and bradykinin, overview
lisinopril
-
-
lisinopril
-
angiotensin-converting enzyme inhibitor enhances the liver regeneration in rats after partial hepatectomy. Angiotensin-converting enzyme enhanced the hepatic regenerative response to PH by two independent mechanisms: an activation of B2 receptors and inhibition of angiotensin II production, both of which may stimulate production of hepatocyte growth factor, resulting in enhancement of the hepatic regeneration
lisinopril
-
therapeutic resistance to angiotensin converting enzyme inhibition is related to a difference in the combination of renal pharmacodynamic and pharmacokinetic characteristics in non-responders, primarily consisting of increased renal expression of angiotensin converting enzyme and higher angiotensin converting enzyme inhibitor clearance
lisinopril
-
treatment with 75 mg/l lisinopril significantly reduces renal ACE activity without affecting renal ACE2 activity
N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-L-proline
-
accelerated nitrotyrosine content in the renal cortex during high-glucose conditions is prevented by treatment with the angiotensin-converting enzyme inhibitor treatment. The suppressed degradation of nitrotyrosine in the renal cortex by the angiotensin-converting enzyme inhibitor enhances both superoxide anion degradation per se and antioxidative effects including activation of superoxide dismutase
N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-L-proline
-
independent of diet enalapril treatment decreases food intake, energetic gain and body weight in normotensive young rats, followed by reduced body fat mass and serum leptin
nicotianamine
-
-
nicotianamine
-
mixed inhibition. The preferential inhibition of circulating and tissue angiotensin I-converting enzyme by nicotianamine can contribute to the suppression of hypertension
perindopril
-
chronic administration of perindopril results in a decrease in body adiposity
perindopril
-
chronic in vivo administration of the angiotensin-converting enzyme inhibitor reduces apoptosis induced via endotoxic shock with Escherichia coli lipopolysaccharides
perindopril
-
in growing spontaneously hypertensive rats, chronic treatment with perindopril enhances untrained exercise capacity, while it does no affect acquired exercise capacity as a result of exercise training. Perindopril promotes adaptive changes of skeletal muscle in response to exercise such as increases in capillary density and percentage of type I fibre
perindopril
-
itssue angiotensin converting enzyme inhibitors
perindopril
-
decreases food intake and circulating insulin in both diet groups, and hepatic ACE activity in high fat fed animals only, while decreased plasma leptin concentration with ACE inhibition is only evident in chow fed animals
quinapril
-
lipophilic ACE inhibitors quinapril, enalapril, and captopril increase the survival and lifetime of rats with experimental chronic heart failure
quinapril
-
the angiotensin-converting enzyme inhibitor has no significant effect on apoptosis induced via endotoxic shock with Escherichia coli lipopolysaccharides
quinapril
-
tissue angiotensin converting enzyme inhibitors
quinapril
-
18 mg/kg quinapril per day feeding for 3 days significantly reduces blood plasma ACE activity by 80%, quinapril administration for 16 days greatly decreases blood plasma ACE activity by 88% with 18 mg/kg per day, ACE activities in the heart, lung, and skeletal muscles of the 16-day ACE-inhibition with 18 mg/kg per day are 9%, 16%, and 22% of the controls, respectively
ramipril
-
-
ramipril
-
in the early phase of diabetes, the angiotensin-converting enzyme inhibitor reverses glomerular overexpression and activation of some critical growth factor pathways and increases protection against oxidative stress. These effects involve B2-kinin receptor activation
ramipril
-
the angiotensin-converting enzyme inhibitor has no significant effect on apoptosis induced via endotoxic shock with Escherichia coli lipopolysaccharides
additional information
effects of metabolites produced from (-)-epigallocatechin gallate by rat intestinal bacteria on angiotensin I-converting enzyme activity and blood pressure in spontaneously hypertensive rats. All of the metabolites show ACE inhibitory activities and the order of IC50 is hydroxyphenyl valeric acids > 5-(3,4,5-trihydroxyphenyl)-gamma-valerolactone > 5-(3,4,5-trihydroxyphenyl) 4-hydroxyvaleric acid >> 5-(3,5-dihydroxyphenyl) 4-hydroxyvaleric acid >> 5-(3,5-dihydroxyphenyl)-gamma-valerolactone. Among the catechins, galloylated catechins exhibit stronger ACE inhibitory activity than nongalloylated catechins. Measurement of systolic blood pressure (SBP) after oral administration
-
additional information
-
-
-
additional information
-
endogenous inhibitor from rat heart may modulate the activity of the enzyme in the heart in response to alterations of the oxidation-reduction balance in the tissue, MW of the inhibitor is about 100000 Da
-
additional information
-
design and properties of N-carboxyalkyldipeptide inhibitors
-
additional information
-
the presence of verticione, verticine, peimisine may be responsible, at least in part, for the antihypertensive action of the bulbs of Fritillaria ussuriensis
-
additional information
-
hot water extract of Tamogi-take mushroom, antihypertensive effect in spontaneously hypertensive rats by oral administration
-
additional information
-
isolation of angiotensin converting enzyme (ACE) inhibitory flavonoids from Sedum sarmentosum
-
additional information
-
angiotensin I-converting enzyme inhibitory peptides from protein hydrolysates by a soybean protease D3
-
additional information
-
tissue angiotensin converting enzyme inhibitors exert more pronounced antithrombotic effect than plasma ACE-Is in experimental thrombosis
-
additional information
-
chicken collagen hydrolysates possess ACE-inhibitory activities, chicken collagen hydrolysates inhibit about 30% of the activity of ACE, whereas further enzymatic treatment doubles their activities
-
additional information
-
not inhibited by MLN4760, SCH39370, amastatin bestatin, chymostatin, and p-chloromercuribenzoate
-
additional information
-
not inhibited by resveratrol
-
additional information
-
2.7fold peptide-enriched soy sauce-like seasoning, termed Fermented Soybean Seasoning, FSS, shows ACE inhibitory activity with an IC50 of 0.454 mg/ml, fermentation method, overview. FSS shows antihypertensive effects, overview
-
additional information
-
ACE inhibitory peptides derived from marine organisms show a strong suppressive effect on systolic blood pressure of spontaneously hypertensive rats, and this antihypertensive activity is similar with captopril, a commercial antihypertensive drug. Hydrophobicity of the N-terminus is one of the common features of ACE inhibitory peptides, and may contribute to the inhibitory activity. No side effect observed on rats after administration of antihypertensive peptides. The peptides exhibit antihypertensive activity in vivo rather than in vitro. An antihypertensive peptide isolated from bonito fish hydrolysate product, is hydrolyzed by ACE to produce a smaller peptide than the initial one, which has 8fold increased ACE inhibitory activity compared with the initial peptide. Polyphenolic compounds inhibit ACE activity through sequestration of the enzyme metal factor, Zn2+ ion
-
additional information
-
metabolic effects of low dose angiotensin converting enzyme inhibitor in dietary obesity in the rat
-
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Eur. J. Pharmacol.
549
124-132
2006
Rattus norvegicus
brenda
Takai, S.; Yamamoto, D.; Jin, D.; Inagaki, S.; Yoshikawa, K.; Tanaka, K.; Miyazaki, M.
Inhibition of matrix metalloproteinase-9 activity by lisinopril after myocardial infarction in hamsters
Eur. J. Pharmacol.
568
231-233
2007
Rattus norvegicus
brenda
Windt, W.A.; van Dokkum, R.P.; Kluppel, C.A.; Jeronimus-Stratingh, C.M.; Hut, F.; de Zeeuw, D.; Henning, R.H.
Therapeutic resistance to angiotensin converting enzyme (ACE) inhibition is related to pharmacodynamic and -kinetic factors in 5/6 nephrectomized rats
Eur. J. Pharmacol.
580
231-240
2008
Rattus norvegicus
brenda
Santos, E.L.; de Picoli Souza, K.; Guimaraes, P.B.; Reis, F.C.; Silva, S.M.; Costa-Neto, C.M.; Luz, J.; Pesquero, J.B.
Effect of angiotensin converting enzyme inhibitor enalapril on body weight and composition in young rats
Int. Immunopharmacol.
8
247-253
2008
Rattus norvegicus
brenda
Gokce, G.; Karboga, H.; Yildiz, E.; Ayan, S.; Gultekin, Y.
Effect of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on apoptotic changes in contralateral testis following unilateral testicular torsion
Int. Urol. Nephrol.
40
989-995
2008
Rattus norvegicus
brenda
Miguel, M.; Manso, M.; Aleixandre, A.; Alonso, M.J.; Salaices, M.; Lopez-Fandino, R.
Vascular effects, angiotensin I-converting enzyme (ACE)-inhibitory activity, and antihypertensive properties of peptides derived from egg white
J. Agric. Food Chem.
55
10615-10621
2007
Rattus norvegicus
brenda
Qian, Z.J.; Je, J.Y.; Kim, S.K.
Antihypertensive effect of angiotensin i converting enzyme-inhibitory peptide from hydrolysates of Bigeye tuna dark muscle, Thunnus obesus
J. Agric. Food Chem.
55
8398-8403
2007
Oryctolagus cuniculus, Rattus norvegicus
brenda
Katayama, K.; Anggraeni, H.E.; Mori, T.; Ahhmed, A.M.; Kawahara, S.; Sugiyama, M.; Nakayama, T.; Maruyama, M.; Muguruma, M.
Porcine skeletal muscle troponin is a good source of peptides with Angiotensin-I converting enzyme inhibitory activity and antihypertensive effects in spontaneously hypertensive rats
J. Agric. Food Chem.
56
355-360
2008
Rattus norvegicus
brenda
Kodera, T.; Nio, N.
Identification of an angiotensin I-converting enzyme inhibitory peptides from protein hydrolysates by a soybean protease and the antihypertensive effects of hydrolysates in spontaneously hypertensive model rats
J. Food Sci.
71
C164-C173
2006
Rattus norvegicus
brenda
Katayama, K.; Katayama, K.; Mori, T.; Kawahara, S.; Miake, K.; Kodama, Y.; Sugiyama, M.; Kawamura, Y.; Nakayama, T.; Maruyama, M.; Muguruma, M.
Angiotensin-I converting enzyme inhibitory peptide derived from porcine skeletal muscle myosin and its antihypertensive activity in spontaneously hypertensive rats
J. Food Sci.
72
S702-S706
2007
Rattus norvegicus
brenda
Minami, N.; Li, Y.; Guo, Q.; Kawamura, T.; Mori, N.; Nagasaka, M.; Ogawa, M.; Ito, O.; Kurosawa, H.; Kanazawa, M.; Kohzuki, M.
Effects of angiotensin-converting enzyme inhibitor and exercise training on exercise capacity and skeletal muscle
J. Hypertens.
25
1241-1248
2007
Rattus norvegicus
brenda
Hayashi, A.; Kimoto, K.
Nicotianamine preferentially inhibits angiotensin I-converting enzyme
J. Nutr. Sci. Vitaminol.
53
331-336
2007
Oryctolagus cuniculus, Rattus norvegicus
brenda
Alaei, H.; Hosseini, M.
Angiotensin converting enzyme inhibitor captopril modifies conditioned place preference induced by morphine and morphine withdrawal signs in rats
Pathophysiology
14
55-60
2007
Rattus norvegicus
brenda
Weisinger, H.S.; Begg, D.P.; Egan, G.F.; Jayasooriya, A.P.; Lie, F.; Mathai, M.L.; Sinclair, A.J.; Wark, J.D.; Weisinger, R.S.
Angiotensin converting enzyme inhibition from birth reduces body weight and body fat in Sprague-Dawley rats
Physiol. Behav.
93
820-825
2008
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Ren, J.; Li, H.; Prior, B.M.; Yang, H.T.
Angiotensin converting enzyme inhibition enhances collateral artery remodeling in rats with femoral artery occlusion
Am. J. Med. Sci.
335
177-187
2008
Rattus norvegicus
brenda
Diaz-Sylvester, P.L.; Fiori, M.C.; Dieguez, S.M.; Mueller, A.C.; Lopardo, M.L.; Amorena, C.E.
Effect of chronic inhibition of converting enzyme on proximal tubule acidification
Am. J. Physiol. Regul. Integr. Comp. Physiol.
294
R2014-R2020
2008
Rattus norvegicus
brenda
Montenegro, M.F.; Pessa, L.R.; Tanus-Santos, J.E.
Isoflavone genistein inhibits the angiotensin-converting enzyme and alters the vascular responses to angiotensin I and bradykinin
Eur. J. Pharmacol.
607
173-177
2009
Rattus norvegicus
brenda
Hamming, I.; van Goor, H.; Turner, A.J.; Rushworth, C.A.; Michaud, A.A.; Corvol, P.; Navis, G.
Differential regulation of renal angiotensin-converting enzyme (ACE) and ACE2 during ACE inhibition and dietary sodium restriction in healthy rats
Exp. Physiol.
93
631-638
2008
Rattus norvegicus
brenda
Diz, D.I.; Garcia-Espinosa, M.A.; Gegick, S.; Tommasi, E.N.; Ferrario, C.M.; Ann Tallant, E.; Chappell, M.C.; Gallagher, P.E.
Injections of angiotensin-converting enzyme 2 inhibitor MLN4760 into nucleus tractus solitarii reduce baroreceptor reflex sensitivity for heart rate control in rats
Exp. Physiol.
93
694-700
2008
Rattus norvegicus
brenda
Saiga, A.; Iwai, K.; Hayakawa, T.; Takahata, Y.; Kitamura, S.; Nishimura, T.; Morimatsu, F.
Angiotensin I-converting enzyme-inhibitory peptides obtained from chicken collagen hydrolysate
J. Agric. Food Chem.
56
9586-9591
2008
Oryctolagus cuniculus, Rattus norvegicus
brenda
Kim, M.Y.; Baik, S.K.; Park, D.H.; Jang, Y.O.; Suk, K.T.; Yea, C.J.; Lee, I.Y.; Kim, J.W.; Kim, H.S.; Kwon, S.O.; Cho, M.Y.; Ko, S.B.; Chang, S.J.; Um, S.H.; Han, K.H.
Angiotensin receptor blockers are superior to angiotensin-converting enzyme inhibitors in the suppression of hepatic fibrosis in a bile duct-ligated rat model
J. Gastroenterol.
43
889-896
2008
Rattus norvegicus
brenda
Richardson, M.A.; Gupta, A.; OBrien, L.A.; Berg, D.T.; Gerlitz, B.; Syed, S.; Sharma, G.R.; Cramer, M.S.; Heuer, J.G.; Galbreath, E.J.; Grinnell, B.W.
Treatment of sepsis-induced acquired protein C deficiency reverses angiotensin-converting enzyme-2 inhibition and decreases pulmonary inflammatory response
J. Pharmacol. Exp. Ther.
325
17-26
2008
Rattus norvegicus
brenda
Olszanecki, R.; Bujak-Gizycka, B.; Madej, J.; Suski, M.; Wolkow, P.P.; Jawien, J.; Korbut, R.
Kaempferol, but not resveratrol inhibits angiotensin converting enzyme
J. Physiol. Pharmacol.
59
387-392
2008
Rattus norvegicus
brenda
Otani, L.; Ninomiya, T.; Murakami, M.; Osajima, K.; Kato, H.; Murakami, T.
Sardine peptide with angiotensin I-converting enzyme inhibitory activity improves glucose tolerance in stroke-prone spontaneously hypertensive rats
Biosci. Biotechnol. Biochem.
73
2203-2209
2009
Rattus norvegicus
brenda
Mecawi, A.S.; Araujo, I.G.; Fonseca, F.V.; Almeida-Pereira, G.; Cortes, W.S.; Rocha, F.F.; Reis, L.C.
Behavioural changes induced by angiotensin-converting enzyme inhibition during pregnancy and lactation in adult offspring rats
Clin. Exp. Pharmacol. Physiol.
36
495-500
2009
Rattus norvegicus
brenda
Thaveau, F.; Zoll, J.; Bouitbir, J.; Nguessan, B.; Plobner, P.; Chakfe, N.; Kretz, J.G.; Richard, R.; Piquard, F.; Geny, B.
Effect of chronic pre-treatment with angiotensin converting enzyme inhibition on skeletal muscle mitochondrial recovery after ischemia/reperfusion
Fundam. Clin. Pharmacol.
24
333-340
2010
Rattus norvegicus
brenda
Nakahara, T.; Sano, A.; Yamaguchi, H.; Sugimoto, K.; Chikata, H.; Kinoshita, E.; Uchida, R.
Antihypertensive effect of peptide-enriched soy sauce-like seasoning and identification of its angiotensin I-converting enzyme inhibitory substances
J. Agric. Food Chem.
58
821-827
2010
Rattus norvegicus
brenda
Lucero, H.A.; Kintsurashvili, E.; Marketou, M.E.; Gavras, H.
Cell signaling, internalization, and nuclear localization of the angiotensin converting enzyme in smooth muscle and endothelial cells
J. Biol. Chem.
285
5555-5568
2010
Rattus norvegicus
brenda
Ogawa, A.; Suzuki, Y.; Aoyama, T.; Takeuchi, H.
Dietary alpha-linolenic acid inhibits angiotensin-converting enzyme activity and mRNA expression levels in the aorta of spontaneously hypertensive rats
J. Oleo Sci.
58
355-360
2009
Rattus norvegicus (P47820)
brenda
Wijesekara, I.; Kim, S.K.
Angiotensin-I-converting enzyme (ACE) inhibitors from marine resources: prospects in the pharmaceutical industry
Mar. Drugs
8
1080-1093
2010
Homo sapiens, Rattus norvegicus
brenda
Adam, A.; Leclair, P.; Montpas, N.; Koumbadinga, G.A.; Bachelard, H.; Marceau, F.
Altered cardiac bradykinin metabolism in experimental diabetes caused by the variations of angiotensin-converting enzyme and other peptidases
Neuropeptides
44
69-75
2010
Rattus norvegicus
brenda
Velkoska, E.; Warner, F.J.; Cole, T.J.; Smith, I.; Morris, M.J.
Metabolic effects of low dose angiotensin converting enzyme inhibitor in dietary obesity in the rat
Nutr. Metab. Cardiovasc. Dis.
20
49-55
2010
Rattus norvegicus
brenda
Wang, Y.K.; Shen, D.; Hao, Q.; Yu, Q.; Wu, Z.T.; Deng, Y.; Chen, Y.F.; Yuan, W.J.; Hu, Q.K.; Su, D.F.; Wang, W.Z.
Overexpression of angiotensin-converting enzyme 2 attenuates tonically active glutamatergic input to the rostral ventrolateral medulla in hypertensive rats
Am. J. Physiol. Heart Circ. Physiol.
307
H182-H190
2014
Rattus norvegicus
brenda
Arutyunyan, T.; Korystova, A.; Kublik, L.; Levitman, M.; Shaposhnikova, V.; Appazov, N.; Narmanova, R.; Ibadullayeva, S.; Korystov, Y.
Camel thorn extract reduces activity of angiotensin-converting enzyme in rat aorta increased during aging and treatment with NO-Synthase inhibitor
Bull. Exp. Biol. Med.
158
222-224
2014
Rattus norvegicus
brenda
Crestani, S.; Gasparotto Junior, A.; Marques, M.C.; Sullivan, J.C.; Webb, R.C.; da Silva-Santos, J.E.
Enhanced angiotensin-converting enzyme activity and systemic reactivity to angiotensin II in normotensive rats exposed to a high-sodium diet
Vascul. Pharmacol.
60
67-74
2014
Rattus norvegicus
brenda
Reis, R.I.; Nogueira, M.D.; Campanha-Rodrigues, A.L.; Pereira, L.M.; Andrade, M.C.C.; Parreiras-E-Silva, L.T.; Costa-Neto, C.M.; Mortara, R.A.; Casarini, D.E.
The binding of captopril to angiotensin I-converting enzyme triggers activation of signaling pathways
Am. J. Physiol. Cell Physiol.
315
C367-C379
2018
Rattus norvegicus (P47820), Rattus norvegicus, Rattus norvegicus Wistar (P47820)
brenda
Zouari, R.; Hamden, K.; El Feki, A.; Chaabouni, K.; Makni-Ayadi, F.; Sallemi, F.; Ellouze-Chaabouni, S.; Ghribi-Aydi, D.
Evaluation of Bacillus subtilis SPB1 biosurfactant effects on hyperglycemia, angiotensin I-converting enzyme (ACE) activity and kidney function in rats fed on high-fat-high-fructose diet
Arch. Physiol. Biochem.
123
112-120
2017
Rattus norvegicus (P47820), Rattus norvegicus, Rattus norvegicus Wistar (P47820)
brenda
Takagaki, A.; Nanjo, F.
Effects of metabolites produced from (-)-epigallocatechin gallate by rat intestinal bacteria on angiotensin I-converting enzyme activity and blood pressure in spontaneously hypertensive rats
J. Agric. Food Chem.
63
8262-8266
2015
Rattus norvegicus (P47820), Rattus norvegicus Wistar (P47820)
brenda