Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Gly-L-Ala-Hyp-Gly-L-Leu-Hyp-Gly-L-Pro | highest ACE-inhibitory activity | Oryctolagus cuniculus | |
Gly-L-Ala-Hyp-Gly-L-Leu-Hyp-Gly-L-Pro | highest ACE-inhibitory activity | Rattus norvegicus | |
Gly-L-Ala-Hyp-Gly-L-Pro-L-Ala-Gly-L-Pro-Gly-Gly-L-Ile-Hyp-Gly-L-Glu-L-Arg-Gly | - |
Oryctolagus cuniculus | |
Gly-L-Ala-Hyp-Gly-L-Pro-L-Ala-Gly-L-Pro-Gly-Gly-L-Ile-Hyp-Gly-L-Glu-L-Arg-Gly | - |
Rattus norvegicus | |
Gly-L-Ile-Hyp-Gly-L-Glu-L-Arg-Gly-L-Pro-L-Val-Gly-L-Pro-L-Ser-Gly | - |
Oryctolagus cuniculus | |
Gly-L-Ile-Hyp-Gly-L-Glu-L-Arg-Gly-L-Pro-L-Val-Gly-L-Pro-L-Ser-Gly | - |
Rattus norvegicus | |
Gly-L-Leu-Hyp-Gly-L-Ser-L-Arg-Gly-L-Glu-L-Arg-Gly-L-Leu-Hyp-Gly | - |
Oryctolagus cuniculus | |
Gly-L-Leu-Hyp-Gly-L-Ser-L-Arg-Gly-L-Glu-L-Arg-Gly-L-Leu-Hyp-Gly | - |
Rattus norvegicus | |
additional information | chicken collagen hydrolysates possess ACE-inhibitory activities, chicken collagen hydrolysates inhibit about 30% of the activity of ACE, whereas further enzymatic treatment doubles their activities | Oryctolagus cuniculus | |
additional information | chicken collagen hydrolysates possess ACE-inhibitory activities, chicken collagen hydrolysates inhibit about 30% of the activity of ACE, whereas further enzymatic treatment doubles their activities | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | Rattus norvegicus | - |
angiotensin II + L-His-L-Leu | - |
? | |
angiotensin I + H2O | Oryctolagus cuniculus | - |
angiotensin II + L-His-L-Leu | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Rattus norvegicus | - |
lung | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | - |
Rattus norvegicus | angiotensin II + L-His-L-Leu | - |
? | |
angiotensin I + H2O | - |
Oryctolagus cuniculus | angiotensin II + L-His-L-Leu | - |
? | |
hippuryl-L-His-L-Leu + H2O | - |
Rattus norvegicus | hippuric acid + L-His-L-Leu | - |
? | |
hippuryl-L-His-L-Leu + H2O | - |
Oryctolagus cuniculus | hippuric acid + L-His-L-Leu | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACE | - |
Rattus norvegicus |
ACE | - |
Oryctolagus cuniculus |
angiotensin I-converting enzyme | - |
Rattus norvegicus |
angiotensin I-converting enzyme | - |
Oryctolagus cuniculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0294 | - |
in 100 mM sodium borate buffer (pH 8.3), 500 mM NaCl, at 37°C | Oryctolagus cuniculus | Gly-L-Ala-Hyp-Gly-L-Leu-Hyp-Gly-L-Pro | |
0.0434 | - |
in 100 mM sodium borate buffer (pH 8.3), 500 mM NaCl, at 37°C | Oryctolagus cuniculus | Gly-L-Ile-Hyp-Gly-L-Glu-L-Arg-Gly-L-Pro-L-Val-Gly-L-Pro-L-Ser-Gly | |
0.0456 | - |
in 100 mM sodium borate buffer (pH 8.3), 500 mM NaCl, at 37°C | Oryctolagus cuniculus | Gly-L-Ala-Hyp-Gly-L-Pro-L-Ala-Gly-L-Pro-Gly-Gly-L-Ile-Hyp-Gly-L-Glu-L-Arg-Gly | |
0.0608 | - |
in 100 mM sodium borate buffer (pH 8.3), 500 mM NaCl, at 37°C | Oryctolagus cuniculus | Gly-L-Leu-Hyp-Gly-L-Ser-L-Arg-Gly-L-Glu-L-Arg-Gly-L-Leu-Hyp-Gly |