Literature summary for 3.4.15.1 extracted from

Hamming, I.; van Goor, H.; Turner, A.J.; Rushworth, C.A.; Michaud, A.A.; Corvol, P.; Navis, G.
Differential regulation of renal angiotensin-converting enzyme (ACE) and ACE2 during ACE inhibition and dietary sodium restriction in healthy rats (2008), Exp. Physiol., 93, 631-638.

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Inhibitors

Inhibitors	Comment	Organism	Structure
lisinopril	treatment with 75 mg/l lisinopril significantly reduces renal ACE activity without affecting renal ACE2 activity	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
angiotensin I + H2O	Rattus norvegicus	-	angiotensin II + L-His-L-Leu	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood plasma	-	Rattus norvegicus	-
kidney	highly expressed in the kidney	Rattus norvegicus	-
renal cortex	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
angiotensin I + H2O	-	Rattus norvegicus	angiotensin II + L-His-L-Leu	-	?
hippuryl-L-His-L-Leu + H2O	-	Rattus norvegicus	hippuric acid + L-His-L-Leu	-	?

Synonyms

Synonyms	Comment	Organism
ACE	-	Rattus norvegicus
angiotensin converting enzyme	-	Rattus norvegicus

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Release 2023.1 (January 2023)