Information on EC 3.2.1.49 - alpha-N-acetylgalactosaminidase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY
3.2.1.49
-
RECOMMENDED NAME
GeneOntology No.
alpha-N-acetylgalactosaminidase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
hydrolysis of O-glycosyl bond
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Glycosphingolipid biosynthesis - globo series
-
SYSTEMATIC NAME
IUBMB Comments
alpha-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase
The human lysosomal enzyme is involved in the degradation of blood type A epitope.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
2-acetamido-2-deoxy-alpha-D-galactoside acetamidodeoxygalactohydrolase
-
-
-
-
4-nitrophenyl-alpha-N-acetylgalactosaminidase
-
-
-
-
AglA
A2QL72
gene name
alpha-acetylgalactosaminidase
-
-
-
-
alpha-galactosidase B
-
-
-
-
alpha-galactosidase B
-
-
alpha-GalNAc
-
-
alpha-GalNAcase
-
-
alpha-GalNAcase I
-
-
alpha-GalNAcase I
-
-
alpha-GalNAcase II
-
-
alpha-GalNAcase II
-
-
alpha-N-acetylgalactosaminidase blood group A2 degrading enzyme
-
-
alpha-N-galactosaminidase IV
-
-
alpha-N-galactosaminidase IV
Arenibacter latericius KMM 426
-
-
-
alpha-NAGA
-
-
alpha-NAGAL
-
-
alpha-NAGAL
P17050
-
alpha-NaGalase
-
-
envelope glycoprotein gp160
-
-
exo-alpha-N-acetylgalactosaminidase
-
-
-
-
N-acetyl-alpha-D-galactosaminidase
-
-
-
-
N-acetyl-alpha-galactosaminidase
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
9075-63-2
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
squid, two isozymes alpha-GalNAcase I and alpha-GalNAcase II
-
-
Manually annotated by BRENDA team
Arenibacter latericius KMM 426
KMM 426
-
-
Manually annotated by BRENDA team
bifunctional alpha-galactosidase and alpha-N-acetylgalactosaminidase
UniProt
Manually annotated by BRENDA team
bifunctional alpha-N-acetylgalactosaminidase and alpha-N-acetylgalactosidase
UniProt
Manually annotated by BRENDA team
strain CCIM K2, best producer of alpha-N-acetylgalactosaminase
-
-
Manually annotated by BRENDA team
Aspergillus niger CCIM
strain CCIM K2, best producer of alpha-N-acetylgalactosaminase
-
-
Manually annotated by BRENDA team
member of glycosyl hydrolase family 109
UniProt
Manually annotated by BRENDA team
Eremoplastron bovis
-
-
-
Manually annotated by BRENDA team
i.e. HIV-1, constitutive enzyme
-
-
Manually annotated by BRENDA team
skipjack tuna
-
-
Manually annotated by BRENDA team
COFACTOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
NAD+
A4Q8F7
binds 1 NAD+ per subunit. The NAD+ cannot dissociate
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Ca2+
-
slight activation of both isozymes
Cu2+
-
slight activation of both isozymes
K+
-
slight activation of both isozymes
Mg2+
-
activates
Mg2+
-
slight activation of both isozymes
Na+
-
slight activation of both isozymes
Zn2+
-
slight activation of both isozymes