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0.0001
1-(2-chlorophenyl)-6-((2R)-3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one
Mus musculus
i.e. BAY 73-6691, IC50: 100 nM
0.000429 - 0.0115
carboxyamidotriazole
0.00000193 - 0.00436
sildenafil
0.000429
carboxyamidotriazole
Mus musculus
-
enzyme from lung, at pH 8.0 and 30°C
0.00267
carboxyamidotriazole
Mus musculus
-
enzyme from peritoneal macrophage, at pH 8.0 and 30°C
0.00705
carboxyamidotriazole
Mus musculus
-
enzyme from RAW264.7 cells, at pH 8.0 and 30°C
0.00898
carboxyamidotriazole
Mus musculus
-
enzyme from Lewis lung carcinoma cells, at pH 8.0 and 30°C
0.0115
carboxyamidotriazole
Mus musculus
-
enzyme from L1210 cells, at pH 8.0 and 30°C
0.00000193
sildenafil
Mus musculus
-
enzyme from lung, at pH 8.0 and 30°C
0.00127
sildenafil
Mus musculus
-
enzyme from Lewis lung carcinoma cells, at pH 8.0 and 30°C
0.00301
sildenafil
Mus musculus
-
enzyme from L1210 cells, at pH 8.0 and 30°C
0.00332
sildenafil
Mus musculus
-
enzyme from RAW264.7 cells, at pH 8.0 and 30°C
0.00436
sildenafil
Mus musculus
-
enzyme from peritoneal macrophage, at pH 8.0 and 30°C
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Giorgi, M.; Caniglia, C.; Scarsella, G.; Augusti-Tocco, G.
Characterization of 3':5' cyclic nucleotide phosphodiesterase activities of mouse neuroblastoma N18TG2 cells
FEBS Lett.
324
76-80
1993
Mus musculus
brenda
Giorgi, M.; Girodano, D.; Caniglia, C.; Biagioni, S.; Augusti-Tocco, G.
Induction of cyclic AMP and cyclic GMP 3:5-cyclic nucleotide phosphodiesterase activities in neuroblastoma lines under differentiating conditions
Int. J. Dev. Neurosci.
15
309-319
1997
Mus musculus
brenda
Giordano, D.; De Stefano, M.E.; Citro, G.; Modica, A.; Giorgi, M.
Expression of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in mouse tissues and cell lines using an antibody against the enzyme amino-terminal domain
Biochim. Biophys. Acta
1539
16-27
2001
Mus musculus
brenda
van Staveren, W.C.; Glick, J.; Markerink-van Ittersum, M.; Shimizu, M.; Beavo, J.A.; Steinbusch, H.W.; de Vente, J.
Cloning and localization of the cGMP-specific phosphodiesterase type 9 in the rat brain
J. Neurocytol.
31
729-741
2002
Mus musculus (O70628), Mus musculus, Rattus norvegicus (Q8QZV1)
brenda
Wunder, F.; Tersteegen, A.; Rebmann, A.; Erb, C.; Fahrig, T.; Hendrix, M.
Characterization of the first potent and selective PDE9 inhibitor using a cGMP reporter cell line
Mol. Pharmacol.
68
1775-1781
2005
Homo sapiens, Mus musculus (O70628), Mus musculus
brenda
Bender, A.T.; Beavo, J.A.
Specific localized expression of cGMP PDEs in Purkinje neurons and macrophages
Neurochem. Int.
45
853-857
2004
Mus musculus
brenda
Tsang, S.H.; Woodruff, M.L.; Chen, C.K.; Yamashita, C.Y.; Cilluffo, M.C.; Rao, A.L.; Farber, D.B.; Fain, G.L.
GAP-independent termination of photoreceptor light response by excess gamma subunit of the cGMP-phosphodiesterase
J. Neurosci.
26
4472-4480
2006
Mus musculus
brenda
Guo, L.W.; Ruoho, A.E.
The retinal cGMP phosphodiesterase gamma-subunit - a chameleon
Curr. Protein Pept. Sci.
9
611-625
2008
Mus musculus
brenda
Wang, S.; Ning, G.; Chen, X.; Yang, J.; Ouyang, H.; Zhang, H.; Tai, P.; Mu, X.; Zhou, B.; Zhang, M.; Xia, G.
PDE5 modulates oocyte spontaneous maturation via cGMP-cAMP but not cGMP-PKG signaling
Front. Biosci.
13
7087-7095
2008
Mus musculus
brenda
Davis, R.J.; Tosi, J.; Janisch, K.M.; Kasanuki, J.M.; Wang, N.K.; Kong, J.; Tsui, I.; Cilluffo, M.; Woodruff, M.L.; Fain, G.L.; Lin, C.S.; Tsang, S.H.
Functional rescue of degenerating photoreceptors in mice homozygous for a hypomorphic cGMP phosphodiesterase 6 b allele (Pde6bH620Q)
Invest. Ophthalmol. Vis. Sci.
49
5067-5076
2008
Mus musculus
brenda
Heikaus, C.C.; Stout, J.R.; Sekharan, M.R.; Eakin, C.M.; Rajagopal, P.; Brzovic, P.S.; Beavo, J.A.; Klevit, R.E.
Solution structure of the cGMP binding GAF domain from phosphodiesterase 5: insights into nucleotide specificity, dimerization, and cGMP-dependent conformational change
J. Biol. Chem.
283
22749-22759
2008
Mus musculus (Q8CG03)
brenda
Sejima, H.; Tominaga, K.; Egawa, T.; Ikeda, M.; Shibuya, K.; Kameyama, N.; Yamauchi, A.; Shuto, H.; Kataoka, Y.
Gender differences in tail-skin flushing induced by nitrates and phosphodiesterase type 5 inhibitors in a climacteric mouse model
Eur. J. Pharmacol.
624
66-70
2009
Mus musculus
brenda
Das, A.; Xi, L.; Kukreja, R.C.
Protein kinase G-dependent cardioprotective mechanism of phosphodiesterase-5 inhibition involves phosphorylation of ERK and GSK3beta
J. Biol. Chem.
283
29572-29585
2008
Mus musculus
brenda
Donato, M.A.; Saraiva, K.L.; Soares e Silva, A.K.; Wanderley, M.I.; Peixoto, C.A.
Follicle development and luteal cell morphology altered by phosphodiesterase-5 inhibitor
Micron
40
845-850
2009
Mus musculus
brenda
Tsang, S.H.; Woodruff, M.L.; Lin, C.S.; Jacobson, B.D.; Naumann, M.C.; Hsu, C.W.; Davis, R.J.; Cilluffo, M.C.; Chen, J.; Fain, G.L.
Effect of the ILE86TER mutation in the gamma subunit of cGMP phosphodiesterase (PDE6) on rod photoreceptor signaling
Cell. Signal.
24
181-188
2011
Mus musculus
brenda
Tosi, J.; Davis, R.J.; Wang, N.K.; Naumann, M.; Lin, C.S.; Tsang, S.H.
shRNA knockdown of guanylate cyclase 2e or cyclic nucleotide gated channel alpha 1 increases photoreceptor survival in a cGMP phosphodiesterase mouse model of retinitis pigmentosa
J. Cell. Mol. Med.
15
1778-1787
2011
Mus musculus, Mus musculus C57/BL6J
brenda
Chu, U.B.; Song, J.; Mavlyutov, T.A.; Guo, L.W.
In vitro interaction of tubulin with the photoreceptor cGMP phosphodiesterase gamma-subunit
Neurosci. Lett.
482
225-229
2010
Bos taurus, Mus musculus
brenda
Kelly, M.P.; Adamowicz, W.; Bove, S.; Hartman, A.J.; Mariga, A.; Pathak, G.; Reinhart, V.; Romegialli, A.; Kleiman, R.J.
Select 3,5-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain
Cell. Signal.
26
383-397
2014
Mus musculus, Rattus norvegicus
brenda
Guo, L.; Luo, L.; Ju, R.; Chen, C.; Zhu, L.; Li, J.; Yu, X.; Ye, C.; Zhang, D.
Carboxyamidotriazole A novel inhibitor of both cAMP-phosphodiesterases and cGMP-phosphodiesterases
Eur. J. Pharmacol.
746
14-21
2015
Mus musculus, Rattus norvegicus
brenda