Cloned (Comment) | Organism |
---|---|
- |
Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
D196A | the mutation disrupts cGMP binding and increases cAMP affinity in constructs containing only GAF (mammalian cGMP-dependent PDEs, Anabaena adenylyl cyclases, and Escherichia coli FhlA), causing an altered cAMP-bound structural conformation | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sildenafil | potent PDE5 inhibitor | Mus musculus | |
tadalafil | potent PDE5 inhibitor | Mus musculus | |
vardenafil | potent PDE5 inhibitor | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8CG03 | - |
- |
Purification (Comment) | Organism |
---|---|
purified without addition of cAMP or cGMP by Superose-12 gel filtration | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cGMP + H2O | PDE5A has a higher selectivity for cGMP due to much lower cAMP binding affinity | Mus musculus | 5'-GMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3',5'-cyclic nucleotide phosphodiesterase 5 | - |
Mus musculus |
PDE5 | - |
Mus musculus |
PDE5A | isoform | Mus musculus |
phosphodiesterase 5 | - |
Mus musculus |