Cloned (Comment) | Organism |
---|---|
- |
Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(2-chlorophenyl)-6-((2R)-3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one | i.e. BAY 73-6691, IC50: 55 nM | Homo sapiens | |
1-(2-chlorophenyl)-6-((2R)-3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one | i.e. BAY 73-6691, IC50: 100 nM | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | O70628 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cGMP + H2O | specific for 3',5'-cGMP | Homo sapiens | 5'-GMP | - |
? | |
3',5'-cGMP + H2O | specific for 3',5'-cGMP | Mus musculus | 5'-GMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
gigh-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | - |
Mus musculus |
PDE9 | - |
Homo sapiens |
PDE9 | - |
Mus musculus |
phosphodiesterase 9 | - |
Homo sapiens |
phosphodiesterase 9 | - |
Mus musculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000045 | - |
1-(2-chlorophenyl)-6-((2R)-3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000055 | - |
i.e. BAY 73-6691, IC50: 55 nM | Homo sapiens | 1-(2-chlorophenyl)-6-((2R)-3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one | |
0.0001 | - |
i.e. BAY 73-6691, IC50: 100 nM | Mus musculus | 1-(2-chlorophenyl)-6-((2R)-3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one |