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Literature summary for 3.1.4.35 extracted from

  • Wunder, F.; Tersteegen, A.; Rebmann, A.; Erb, C.; Fahrig, T.; Hendrix, M.
    Characterization of the first potent and selective PDE9 inhibitor using a cGMP reporter cell line (2005), Mol. Pharmacol., 68, 1775-1781.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
1-(2-chlorophenyl)-6-((2R)-3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one i.e. BAY 73-6691, IC50: 55 nM Homo sapiens
1-(2-chlorophenyl)-6-((2R)-3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one i.e. BAY 73-6691, IC50: 100 nM Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus O70628
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cGMP + H2O specific for 3',5'-cGMP Homo sapiens 5'-GMP
-
?
3',5'-cGMP + H2O specific for 3',5'-cGMP Mus musculus 5'-GMP
-
?

Synonyms

Synonyms Comment Organism
gigh-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
-
Mus musculus
PDE9
-
Homo sapiens
PDE9
-
Mus musculus
phosphodiesterase 9
-
Homo sapiens
phosphodiesterase 9
-
Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000045
-
1-(2-chlorophenyl)-6-((2R)-3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000055
-
i.e. BAY 73-6691, IC50: 55 nM Homo sapiens 1-(2-chlorophenyl)-6-((2R)-3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one
0.0001
-
i.e. BAY 73-6691, IC50: 100 nM Mus musculus 1-(2-chlorophenyl)-6-((2R)-3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one