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Synonyms
ikappabalpha, ikkbeta, ikappab kinase, ikkalpha, ikk complex, lrrk2 kinase, tank-binding kinase 1, ikk-beta, ikkepsilon, ikk-2,
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S1627
preferentially inhibits the beta-subunit of the IKK complex. Specific inhibition of I-kappaB kinase by S1627 modulates the nociceptive response in various nociceptive models in rats. S1627 inhibits the activation of NF-kappaB in the spinal cord and thereby thermal and mechanical hyperalgesia in the zymosan-induced paw inflammation model and the inflammatory edema. It also reduces tactile and cold allodynia in a model of neuropathic pain
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SC-514
i.e. 4-amino-[2,3'-bithiophene]-5-carboxamide
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TPCA-1
i.e. 5-[(4-fluorophenyl)-2-ureido]thiophene-3-carboxamide
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2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7yl)pyridin-2-yl)methyl)acetamide
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BMS-066, inhibitor of IKKbeta
4-(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline
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BMS-345541, inhibitor of IKKbeta
8-(5-chloro-2-(4-methylpiperazin-1-yl)isonicotinamido)-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide
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PHA-408, ATP-competitive, selective IKK-2 inhibitor
PHA-408
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selective IKK-2 inhibitor
tetrandrine
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a bis-benzylisoquinoline alkaloid isolated from the roots of Han-Fang-Ji (Stephania Tetrandra S Moore) effectively inhibits IKKs phosphorylation
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S177E/S181E
overexpression of a constitutively active IKKbeta-EGFP show a marked increase in NF-kappaB activity and a decrease in fiber size of weight-bearing soleus muscles, while muscles overexpressing wild-type IKKbeta-HA have no effect
S176E/S180E
overexpression of a constitutively active IKKalpha-EGFP fusion protein shows that IKKalpha is sufficient to activate NF-kappaB activity and induce fiber atrophy in muscle
K44M
gene transfer of a dominant negative (kinase-dead form) IKKbeta into rat soleus muscles show complete inhibition of 7-day disuse-induced activation of a kappaB reporter gene, while overexpression of wild-type IKKbeta does not. Overexpression of a dominant-negative mutant IKKbeta-EGFP fusion protein show that atrophy is inhibited by 50%, indicating that IKKbeta is required for the atrophy process
K44M
overexpression of a dominant negative (kinase-dead form) IKKbeta plus dominant-negative IKKalpha show an additive effect on the inhibition of disuse atrophy (70%), suggesting that both kinases of the IKK complex are required for muscle atrophy
K44M
overexpression of a dominant negative (kinase-dead form) IKKbeta plus dominant-negative IKKalpha show an additive effect on the inhibition of disuse atrophy (70%), suggesting that both kinases of the IKK complex are required for muscle atrophy
K44M
overexpression of a dominat-negative (kinase-dead form) of the IKKalpha protein decreases unloading-induced NF-kappaB activation and inhibits atrophy by 50%, while overexpression of the wild-type protein has no effect
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Jobin, C.; Sartor, R.B.
The I kappa B/NF-kappa B system: a key determinant of mucosalinflammation and protection
Am. J. Physiol.
278
C451-462
2000
Homo sapiens (O14920), Homo sapiens (O15111), Mus musculus (O88351), Mus musculus (Q60680), Rattus norvegicus (Q9QY78)
brenda
Nemoto, S.; DiDonato, J.A.; Lin, A.
Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase
Mol. Cell. Biol.
18
7336-7343
1998
Homo sapiens (O14920), Homo sapiens (O15111), Mus musculus (O88351), Mus musculus (Q60680), Rattus norvegicus (Q9QY78)
brenda
Lubin, F.D.; Sweatt, J.D.
The IkappaB kinase regulates chromatin structure during reconsolidation of conditioned fear memories
Neuron
55
942-957
2007
Rattus norvegicus
brenda
Niederberger, E.; Geisslinger, G.
The IKK-NF-kB pathway: a source for novel molecular drug targets in pain therapy?
FASEB J.
22
3432-3442
2008
Mus musculus (O88351), Rattus norvegicus (Q9QY78)
brenda
Van Gammeren, D.; Damrauer, J.S.; Jackman, R.W.; Kandarian, S.C.
The IkappaB kinases IKKalpha and IKKbeta are necessary and sufficient for skeletal muscle atrophy
FASEB J.
23
362-370
2008
Rattus norvegicus, Rattus norvegicus (Q9QY78)
brenda
Lin, S.T.; Wang, Y.; Xue, Y.; Feng, D.C.; Xu, Y.; Xu, L.Y.
Tetrandrine suppresses LPS-induced astrocyte activation via modulating IKKs-IkappaBalpha-NF-kappaB signaling pathway
Mol. Cell. Biochem.
315
41-49
2008
Rattus norvegicus
brenda
Chiang, P.C.; Kishore, N.N.; Thompson, D.C.
Combined use of pharmacokinetic modeling and a steady-state delivery approach allows early assessment of IkappaB kinase-2 (IKK-2) target safety and efficacy
J. Pharm. Sci.
99
1278-1287
2010
Rattus norvegicus
brenda
Mbalaviele, G.; Sommers, C.D.; Bonar, S.L.; Mathialagan, S.; Schindler, J.F.; Guzova, J.A.; Shaffer, A.F.; Melton, M.A.; Christine, L.J.; Tripp, C.S.; Chiang, P.C.; Thompson, D.C.; Hu, Y.; Kishore, N.
A novel, highly selective, tight binding IkappaB kinase-2 (IKK-2) inhibitor: a tool to correlate IKK-2 activity to the fate and functions of the components of the nuclear factor-kappaB pathway in arthritis-relevant cells and animal models
J. Pharmacol. Exp. Ther.
329
14-25
2009
Rattus norvegicus, Homo sapiens (O14920), Homo sapiens (Q15111)
brenda
Gillooly, K.M.; Pattoli, M.A.; Taylor, T.L.; Chen, L.; Cheng, L.; Gregor, K.R.; Whitney, G.S.; Susulic, V.; Watterson, S.H.; Kempson, J.; Pitts, W.J.; Booth-Lute, H.; Yang, G.; Davies, P.; Kukral, D.W.; Strnad, J.; McIntyre, K.W.; Darienzo, C.J.; Salter-Cid, L.; Yang, Z.; Wang-Iverson, D.B.; Burke, J.R.
Periodic, partial inhibition of IkappaB kinase beta-mediated signaling yields therapeutic benefit in preclinical models of rheumatoid arthritis
J. Pharmacol. Exp. Ther.
331
349-360
2009
Canis lupus familiaris, Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Rajendrasozhan, S.; Hwang, J.W.; Yao, H.; Kishore, N.; Rahman, I.
Anti-inflammatory effect of a selective IkappaB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke
Pulm. Pharmacol. Ther.
23
172-181
2010
Rattus norvegicus
brenda
Kwon, Y.; Choi, S.K.; Byeon, S.; Lee, Y.H.
Involvement of inhibitor kappa B kinase 2 (IKK2) in the regulation of vascular tone
Lab. Invest.
98
1311-1319
2018
Rattus norvegicus (Q9QY78)
brenda