Application | Comment | Organism |
---|---|---|
medicine | the IKKbeta/IKK2 inhibitor PHA-408 is a powerful anti-inflammatory agent against LPS- and cigarette smoke-mediated lung inflammation | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
8-(5-chloro-2-(4-methylpiperazin-1-yl)isonicotinamido)-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide | PHA-408, ATP-competitive, selective IKK-2 inhibitor | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [IkappaB protein] | Rattus norvegicus | - |
ADP + [IkappaB phosphoprotein] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
adult Sprague-Dawley rat | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [IkappaB protein] | - |
Rattus norvegicus | ADP + [IkappaB phosphoprotein] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IkappaB kinase-beta | - |
Rattus norvegicus |
IKKbeta | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | IkappaB kinase activates NF-kappaB which plays a pivotal role in pro-inflammatory response in the lung | Rattus norvegicus |