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Literature summary for 2.7.11.10 extracted from

  • Van Gammeren, D.; Damrauer, J.S.; Jackman, R.W.; Kandarian, S.C.
    The IkappaB kinases IKKalpha and IKKbeta are necessary and sufficient for skeletal muscle atrophy (2008), FASEB J., 23, 362-370.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.10

Application

Application Comment Organism
medicine the IkappaB kinases IKKalpha and IKKbeta are necessary and sufficient for skeletal muscle atrophy Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
K44M gene transfer of a dominant negative (kinase-dead form) IKKbeta into rat soleus muscles show complete inhibition of 7-day disuse-induced activation of a kappaB reporter gene, while overexpression of wild-type IKKbeta does not. Overexpression of a dominant-negative mutant IKKbeta-EGFP fusion protein show that atrophy is inhibited by 50%, indicating that IKKbeta is required for the atrophy process Rattus norvegicus
K44M overexpression of a dominant negative (kinase-dead form) IKKbeta plus dominant-negative IKKalpha show an additive effect on the inhibition of disuse atrophy (70%), suggesting that both kinases of the IKK complex are required for muscle atrophy Rattus norvegicus
K44M overexpression of a dominat-negative (kinase-dead form) of the IKKalpha protein decreases unloading-induced NF-kappaB activation and inhibits atrophy by 50%, while overexpression of the wild-type protein has no effect Rattus norvegicus
S176E/S180E overexpression of a constitutively active IKKalpha-EGFP fusion protein shows that IKKalpha is sufficient to activate NF-kappaB activity and induce fiber atrophy in muscle Rattus norvegicus
S177E/S181E overexpression of a constitutively active IKKbeta-EGFP show a marked increase in NF-kappaB activity and a decrease in fiber size of weight-bearing soleus muscles, while muscles overexpressing wild-type IKKbeta-HA have no effect Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Rattus norvegicus Q9QY78
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Synonyms

Synonyms Comment Organism
IKKalpha
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 Rattus norvegicus
IKKbeta
-
 Rattus norvegicus