Reference on EC 2.7.1.153 - phosphatidylinositol-4,5-bisphosphate 3-kinase and Organism(s) Homo sapiens and UniProt Accession O00329
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vanhaesebroeck, B.; Leevers, S.J.; Ahmadi, K.; Timms, J.; Katso, R.; Driscoll, P.C.; Woscholski, R.; Parker, P.J.; Waterfield, M.D.
Synthesis and function of 3-phosphorylated inositol lipids
Annu. Rev. Biochem.
70
535-602
2001
Caenorhabditis elegans, Dictyostelium discoideum, Drosophila melanogaster, Homo sapiens, Mammalia
Metzner, B.; Heger, M.; Hofmann, C.; Czech, W.; Norgauer, J.
Evidence for the involvement of phosphatidylinositol 4,5-bisphosphate 3-kinase in CD18-mediated adhesion of human neutrophils to fibrinogen
Biochem. Biophys. Res. Commun.
232
719-723
1997
Homo sapiens
Vanhaesebroeck, B.; Welham, M.J.; Kotani, K.; Stein, R.; Warne, P.H.; Zvelebil, M.J.; Higashi, K.; Volinia, S.; Downward, J.; Waterfield, M.D.
P110delta, a novel phosphoinositide 3-kinase in leukocytes
Proc. Natl. Acad. Sci. USA
94
4330-4335
1997
Homo sapiens (O00329)
Chantry, D.; Vojtek, A.; Kashishian, A.; Holtzman, D.A.; Wood, C.; Gray, P.W.; Cooper, J.A.; Hoekstra, M.F.
p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes
J. Biol. Chem.
272
19236-19241
1997
Homo sapiens (O00329), Homo sapiens
Stoyanov, B.; Volinia, S.; Hanck, T.; Rubio, I.; Loubtchenkov, M.; Malek, D.; Stoyanova, S.; Vanhaesebroeck, B.; Dhand, R.; et al.
Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase
Science
269
690-693
1995
Homo sapiens (P48736)
Stirdivant, S.M.; Ahern, J.; Conroy, R.R.; Barnett, S.F.; Ledder, L.M.; Oliff, A.; Heimbrook, D.C.
Cloning and mutagenesis of the p110 alpha subunit of human phosphoinositide 3'-hydroxykinase
Bioorg. Med. Chem.
5
65-74
1997
Homo sapiens (P42336)
Turner, S.J.; Domin, J.; Waterfield, M.D.; Ward, S.G.; Westwick, J.
The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2alpha
J. Biol. Chem.
273
25987-25995
1998
Homo sapiens
Jackson, S.P.; Schoenwaelder, S.M.; Matzaris, M.; Brown, S.; Mitchell, C.A.
Phosphatidylinositol 3,4,5-trisphosphate is a substrate for the 75 kDa inositol polyphosphate 5-phosphatase and a novel 5-phosphatase which forms a complex with the p85/p110 form of phosphoinositide 3-kinase
EMBO J.
14
4490-4500
1995
Homo sapiens
Kurosu, H.; Katada, T.
Association of phosphatidylinositol 3-kinase composed of p110beta-catalytic and p85-regulatory subunits with the small GTPase Rab5
J. Biochem.
130
73-78
2001
Homo sapiens
Maier, U.; Babich, A.; Nurnberg, B.
Roles of non-catalytic subunits in Gbg-induced activation of class I phosphoinositide 3-kinase isoforms b and g
J. Biol. Chem.
274
29311-29317
1999
Homo sapiens (P48736)
Brock, C.; Schaefer, M.; Reusch, H.P.; Czupalla, C.; Michalke, M.; Spicher, K.; Schultz, G.; Nurnberg, B.
Roles of Gbg in membrane recruitment and activation of p110gamma/p101 phosphoinositide 3-kinase gamma
J. Cell Biol.
160
89-99
2003
Homo sapiens (P48736)
Hu, P.; Mondino, A.; Skolnik, E.Y.; Schlessinger, J.
Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85
Mol. Cell. Biol.
13
7677-7688
1993
Homo sapiens (P42338), Homo sapiens
Raynaud, F.I.; Eccles, S.; Clarke, P.A.; Hayes, A.; Nutley, B.; Alix, S.; Henley, A.; Di-Stefano, F.; Ahmad, Z.; Guillard, S.; Bjerke, L.M.; Kelland, L.; Valenti, M.; Patterson, L.; Gowan, S.; de Haven Brandon, A.; Hayakawa, M.; Kaizawa, H.; Koizumi, T.; Ohishi, T.; Patel, S.; Saghir, N.; Parker, P.; Waterfield, M.; Workman, P.
Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases
Cancer Res.
67
5840-5850
2007
Homo sapiens
Park, S.; Chapuis, N.; Bardet, V.; Tamburini, J.; Gallay, N.; Willems, L.; Knight, Z.A.; Shokat, K.M.; Azar, N.; Viguie, F.; Ifrah, N.; Dreyfus, F.; Mayeux, P.; Lacombe, C.; Bouscary, D.
PI-103, a dual inhibitor of class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML
Leukemia
22
1698-1706
2008
Homo sapiens
Preuss, I.; Kurig, B.; Nuernberg, B.; Orth, J.H.; Aktories, K.
Pasteurella multocida toxin activates Gbetagamma dimers of heterotrimeric G proteins
Cell. Signal.
21
551-558
2009
Homo sapiens
Knowles, M.A.; Platt, F.M.; Ross, R.L.; Hurst, C.D.
Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer
Cancer Metastasis Rev.
28
305-316
2009
Homo sapiens
Renner, O.; Blanco-Aparicio, C.; Grassow, M.; Canamero, M.; Leal, J.F.; Carnero, A.
Activation of phosphatidylinositol 3-kinase by membrane localization of p110alpha predisposes mammary glands to neoplastic transformation
Cancer Res.
68
9643-9653
2008
Homo sapiens, Mus musculus
Chiarini, F.; Fala, F.; Tazzari, P.L.; Ricci, F.; Astolfi, A.; Pession, A.; Pagliaro, P.; McCubrey, J.A.; Martelli, A.M.
Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia
Cancer Res.
69
3520-3528
2009
Homo sapiens
Psyrri, A.; Papageorgiou, S.; Liakata, E.; Scorilas, A.; Rontogianni, D.; Kontos, C.K.; Argyriou, P.; Pectasides, D.; Harhalakis, N.; Pappa, V.; Kolialexi, A.; Economopoulou, C.; Kontsioti, F.; Maratou, E.; Dimitriadis, G.; Economopoulou, P.; Economopoulos, T.
Phosphatidylinositol 3-kinase catalytic subunit alpha gene amplification contributes to the pathogenesis of mantle cell lymphoma
Clin. Cancer Res.
15
5724-5732
2009
Homo sapiens
Rivard, N.
Phosphatidylinositol 3-kinase: a key regulator in adherens junction formation and function
Front. Biosci.
14
510-522
2009
Canis lupus familiaris, Homo sapiens
Kim, J.J.; Choi, Y.M.; Hong, M.A.; Hwang, S.S.; Yoon, S.H.; Chae, S.J.; Jee, B.C.; Ku, S.Y.; Kim, J.G.; Moon, S.Y.
Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene Met326Ile polymorphism in women with polycystic ovary syndrome
Hum. Reprod.
24
1184-1190
2009
Homo sapiens
Chamberlain, M.D.; Chan, T.; Oberg, J.C.; Hawrysh, A.D.; James, K.M.; Saxena, A.; Xiang, J.; Anderson, D.H.
Disrupted RabGAP function of the p85 subunit of phosphatidylinositol 3-kinase results in cell transformation
J. Biol. Chem.
283
15861-15868
2008
Homo sapiens
Cammer, M.; Gevrey, J.C.; Lorenz, M.; Dovas, A.; Condeelis, J.; Cox, D.
The mechanism of CSF-1-induced Wiskott-Aldrich syndrome protein activation in vivo: a role for phosphatidylinositol 3-kinase and Cdc42
J. Biol. Chem.
284
23302-23311
2009
Homo sapiens
Desai, L.P.; White, S.R.; Waters, C.M.
Cyclic mechanical stretch decreases cell migration by inhibiting phosphatidylinositol 3-kinase (PI3-kinase) and focal adhesion kinase (FAK) mediated c-Jun N-terminal kinase-1 (JNK1) activation
J. Biol. Chem.
285
4511-4519
2009
Homo sapiens
Ihle, N.T.; Powis, G.
Take your PIK: phosphatidylinositol 3-kinase inhibitors race through the clinic and toward cancer therapy
Mol. Cancer Ther.
8
1-9
2009
Homo sapiens
Munugalavadla, V.; Vemula, S.; Sims, E.C.; Krishnan, S.; Chen, S.; Yan, J.; Li, H.; Niziolek, P.J.; Takemoto, C.; Robling, A.G.; Yang, F.C.; Kapur, R.
The p85alpha subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration
Mol. Cell. Biol.
28
7182-7198
2008
Homo sapiens
Gavard, J.; Hou, X.; Qu, Y.; Masedunskas, A.; Martin, D.; Weigert, R.; Li, X.; Gutkind, J.S.
A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability
Mol. Cell. Biol.
29
2469-2480
2009
Homo sapiens, Mus musculus
Zhang, X.; Deng, H.X.; Zhao, X.; Su, D.; Chen, X.C.; Chen, L.J.; Wei, Y.Q.; Zhong, Q.; Li, Z.Y.; He, X.; Yi, T.
RNA interference-mediated silencing of the phosphatidylinositol 3-kinase catalytic subunit attenuates growth of human ovarian cancer cells in vitroand in vivo
Oncology
77
22-32
2009
Homo sapiens
Tachado, S.D.; Samrakandi, M.M.; Cirillo, J.D.
Non-opsonic phagocytosis of Legionella pneumophila by macrophages is mediated by phosphatidylinositol 3-kinase
PLoS ONE
3
e3324
2008
Homo sapiens
Zhao, L.; Vogt, P.K.
Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms
Proc. Natl. Acad. Sci. USA
105
2652-2657
2008
Homo sapiens
Akashi, T.; Yamori, T.
Proteomic analysis of phosphoproteins sensitive to a phosphatidylinositol 3-kinase inhibitor, ZSTK474, by using SELDI-TOF MS
Proteome Sci.
7
14
2009
Homo sapiens
Marwick, J.A.; Chung, K.F.; Adcock, I.M.
Phosphatidylinositol 3-kinase isoforms as targets in respiratory disease
Ther. Adv. Respir. Dis.
2009
1-16
2010
Homo sapiens, Mus musculus
Lin, H.; Erhard, K.; Hardwicke, M.A.; Luengo, J.I.; Mack, J.F.; McSurdy-Freed, J.; Plant, R.; Raha, K.; Rominger, C.M.; Sanchez, R.M.; Schaber, M.D.; Schulz, M.J.; Spengler, M.D.; Tedesco, R.; Xie, R.; Zeng, J.J.; Rivero, R.A.
Synthesis and structure-activity relationships of imidazo[1,2-a]pyrimidin-5(1H)-ones as a novel series of beta isoform selective phosphatidylinositol 3-kinase inhibitors
Bioorg. Med. Chem. Lett.
22
2230-2234
2012
Homo sapiens (P42338)
Sanchez, R.M.; Erhard, K.; Hardwicke, M.A.; Lin, H.; McSurdy-Freed, J.; Plant, R.; Raha, K.; Rominger, C.M.; Schaber, M.D.; Spengler, M.D.; Moore, M.L.; Yu, H.; Luengo, J.I.; Tedesco, R.; Rivero, R.A.
Synthesis and structure-activity relationships of 1,2,4-triazolo[1,5-a]pyrimidin-7(3H)-ones as novel series of potent beta isoform selective phosphatidylinositol 3-kinase inhibitors
Bioorg. Med. Chem. Lett.
22
3198-3202
2012
Homo sapiens (P42338)
Large, J.M.; Torr, J.E.; Raynaud, F.I.; Clarke, P.A.; Hayes, A.; Stefano, F.d.; Urban, F.; Shuttleworth, S.J.; Saghir, N.; Sheldrake, P.; Workman, P.; McDonald, E.
Preparation and evaluation of trisubstituted pyrimidines as phosphatidylinositol 3-kinase inhibitors. 3-Hydroxyphenol analogues and bioisosteric replacements
Bioorg. Med. Chem.
19
836-851
2011
Homo sapiens (P42336)
Lannutti, B.J.; Meadows, S.A.; Herman, S.E.; Kashishian, A.; Steiner, B.; Johnson, A.J.; Byrd, J.C.; Tyner, J.W.; Loriaux, M.M.; Deininger, M.; Druker, B.J.; Puri, K.D.; Ulrich, R.G.; Giese, N.A.
CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
Blood
117
591-594
2011
Homo sapiens (O00329)
Gao, M.; Wang, J.; Wang, W.; Liu, J.; Wong, C.W.
Phosphatidylinositol 3-kinase affects mitochondrial function in part through inducing peroxisome proliferator-activated receptor gamma coactivator-1beta expression
Br. J. Pharmacol.
162
1000-1008
2011
Homo sapiens
Wu, Y.; Tan, H.; Shui, G.; Bauvy, C.; Huang, Q.; Wenk, M.; Ong, C.; Codogno, P.; Shen, H.
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase
J. Biol. Chem.
285
10850-10861
2010
Homo sapiens, Mus musculus
Runyan, C.E.; Liu, Z.; Schnaper, H.W.
Phosphatidylinositol 3-kinase and Rab5 GTPase inversely regulate the Smad anchor for receptor activation (SARA) protein independently of transforming growth factor-beta1
J. Biol. Chem.
287
35815-35824
2012
Homo sapiens (P27986)
Fernandez-Acero, T.; Rodriguez-Escudero, I.; Vicente, F.; Monteiro, M.C.; Tormo, J.R.; Cantizani, J.; Molina, M.; Cid, V.J.
A yeast-based in vivo bioassay to screen for class I phosphatidylinositol 3-kinase specific inhibitors
J. Biomol. Screen.
17
1018-1029
2012
Homo sapiens (P42336)
Arancibia, S.; Benitez, D.; Nunez, L.; Jewell, C.; Langjahr, P.; Candia, E.; Zapata-Torres, G.; Cidlowski, J.; Gonzalez, M.; Hermoso, M.
Phosphatidylinositol 3-kinase interacts with the glucocorticoid receptor upon TLR2 activation
J. Cell. Mol. Med.
15
339-349
2011
Homo sapiens
Chen, Z.; Venkatesan, A.M.; Dehnhardt, C.M.; Ayral-Kaloustian, S.; Brooijmans, N.; Mallon, R.; Feldberg, L.; Hollander, I.; Lucas, J.; Yu, K.; Kong, F.; Mansour, T.S.
Synthesis and SAR of novel 4-morpholinopyrrolopyrimidine derivatives as potent phosphatidylinositol 3-kinase inhibitors
J. Med. Chem.
53
3169-3182
2010
Homo sapiens (P42336), Homo sapiens
Rewcastle, G.W.; Gamage, S.A.; Flanagan, J.U.; Frederick, R.; Denny, W.A.; Baguley, B.C.; Kestell, P.; Singh, R.; Kendall, J.D.; Marshall, E.S.; Lill, C.L.; Lee, W.J.; Kolekar, S.; Buchanan, C.M.; Jamieson, S.M.; Shepherd, P.R.
Synthesis and biological evaluation of novel analogues of the pan class I phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474)
J. Med. Chem.
54
7105-7126
2011
Homo sapiens (P48736), Homo sapiens
Smith, A.L.; DAngelo, N.D.; Bo, Y.Y.; Booker, S.K.; Cee, V.J.; Herberich, B.; Hong, F.T.; Jackson, C.L.; Lanman, B.A.; Liu, L.; Nishimura, N.; Pettus, L.H.; Reed, A.B.; Tadesse, S. et al.
Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases
J. Med. Chem.
55
5188-5219
2012
Homo sapiens (P42336), Homo sapiens (P48736)
Moir, L.M.; Trian, T.; Ge, Q.; Shepherd, P.R.; Burgess, J.K.; Oliver, B.G.; Black, J.L.
Phosphatidylinositol 3-kinase isoform-specific effects in airway mesenchymal cell function
J. Pharmacol. Exp. Ther.
337
557-566
2011
Homo sapiens
Kong, D.; Zhang, Y.; Yamori, T.; Duan, H.; Jin, M.
Inhibitory activity of flavonoids against class I phosphatidylinositol 3-kinase isoforms
Molecules
16
5159-5167
2011
Homo sapiens
Vantler, M.; Jesus, J.; Leppaenen, O.; Scherner, M.; Berghausen, E.M.; Mustafov, L.; Chen, X.; Kramer, T.; Zierden, M.; Gerhardt, M.; Ten Freyhaus, H.; Blaschke, F.; Sterner-Kock, A.; Baldus, S.; Zhao, J.J.; Rosenkranz, S.
Class IA phosphatidylinositol 3-kinase isoform p110alpha mediates vascular remodeling
Arterioscler. Thromb. Vasc. Biol.
35
1434-1444
2015
Rattus norvegicus, Rattus norvegicus (A0A0G2K344), Rattus norvegicus (Q9Z1L0), Homo sapiens (O00329), Homo sapiens (P42336), Homo sapiens (P42338), Homo sapiens, Mus musculus (O35904), Mus musculus (P42337), Mus musculus
Dickson, J.; Lee, W.; Shepherd, P.; Buchanan, C.
Enzyme activity effects of N-terminal His-tag attached to catalytic sub-unit of phosphoinositide-3-kinase
Biosci. Rep.
33
857-863
2013
Homo sapiens (P27986 AND P42336), Homo sapiens (P42338 AND O00329)
-
Fernandez-Acero, T.; Rodriguez-Escudero, I.; Molina, M.; Cid, V.J.
The yeast cell wall integrity pathway signals from recycling endosomes upon elimination of phosphatidylinositol (4,5)-bisphosphate by mammalian phosphatidylinositol 3-kinase
Cell. Signal.
27
2272-2284
2015
Homo sapiens (P42336 AND P27986)
Watson, L.J.; Alexander, K.M.; Mohan, M.L.; Bowman, A.L.; Mangmool, S.; Xiao, K.; Naga Prasad, S.V.; Rockman, H.A.
Phosphorylation of Src by phosphoinositide 3-kinase regulates beta-adrenergic receptor-mediated EGFR transactivation
Cell. Signal.
28
1580-1592
2016
Homo sapiens (P48736)
Echeverria, I.; Liu, Y.; Gabelli, S.; Amzel, L.
Oncogenic mutations weaken the interactions that stabilize the p110?-p85? heterodimer in phosphatidylinositol 3-kinase ?.
FEBS J.
282
3528-3542
2015
Homo sapiens (P42336)
Thapa, N.; Choi, S.; Tan, X.; Wise, T.; Anderson, R.A.
Phosphatidylinositol phosphate 5-kinase Igamma and phosphoinositide 3-kinase/Akt signaling couple to promote oncogenic growth
J. Biol. Chem.
290
18843-18854
2015
Homo sapiens (P42336), Homo sapiens (P42338)
Somoza, J.R.; Koditek, D.; Villasenor, A.G.; Novikov, N.; Wong, M.H.; Liclican, A.; Xing, W.; Lagpacan, L.; Wang, R.; Schultz, B.E.; Papalia, G.A.; Samuel, D.; Lad, L.; McGrath, M.E.
Structural, biochemical, and biophysical characterization of idelalisib binding to phosphoinositide 3-kinase delta
J. Biol. Chem.
290
8439-8446
2015
Homo sapiens (O00329), Homo sapiens
Thomas, D.; Powell, J.A.; Green, B.D.; Barry, E.F.; Ma, Y.; Woodcock, J.; Fitter, S.; Zannettino, A.C.; Pitson, S.M.; Hughes, T.P.; Lopez, A.F.; Shepherd, P.R.; Wei, A.H.; Ekert, P.G.; Guthridge, M.A.
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival
PLoS Biol.
11
e1001515
2013
Homo sapiens (P42336), Homo sapiens
Li, D.; Yang, J.; Ma, H.; Sun, C.; Feng, R.
Inositol polyphosphate-4-phosphatase type II and rucaparib treatment inhibit the growth of osteosarcoma cells dependent on phosphoinositide 3-kinase/protein kinase B pathway
J. Cell. Biochem.
119
9899-9909
2018
Homo sapiens
Pridham, K.J.; Varghese, R.T.; Sheng, Z.
The role of class IA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits in glioblastoma
Front. Oncol.
7
312
2017
Homo sapiens (P42336 AND P42338 AND P48736 AND O00329)
Bhattacharya, S.; McElhanon, K.E.; Gushchina, L.V.; Weisleder, N.
Role of phosphatidylinositol-4,5-bisphosphate 3-kinase signaling in vesicular trafficking
Life Sci.
167
39-45
2016
Homo sapiens (P42336 AND P42338 AND P48736 AND O00329)
Denorme, P.; Morren, M.A.; Hollants, S.; Spaepen, M.; Suaer, K.; Zutterman, N.; Labarque, V.; Legius, E.; Brems, H.
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA)-related overgrowth spectrum A brief report
Pediatr. Dermatol.
35
e186-e188
2018
Homo sapiens (P42336)
