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Literature summary for 2.7.1.153 extracted from

  • Stoyanov, B.; Volinia, S.; Hanck, T.; Rubio, I.; Loubtchenkov, M.; Malek, D.; Stoyanova, S.; Vanhaesebroeck, B.; Dhand, R.; et al.
    Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase (1995), Science, 269, 690-693.
    View publication on PubMed
Search for more literature for 2.7.1.153

Activating Compound

Activating Compound Comment Organism Structure
G-protein alpha, beta and gamma subunit strong Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Wortmannin in nanomolar range Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
110000
-
 x * 120000, calculated, x * 110000, SDS-PAGE Homo sapiens
120000
-
 x * 120000, calculated, x * 110000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P48736 p110 catalytic subunit, gamma isoform
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
pancreas
-
 Homo sapiens
-
skeletal muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 120000, calculated, x * 110000, SDS-PAGE Homo sapiens
More no interaction with regulatory subunit p85 Homo sapiens