Reference on EC 2.1.2.1 - glycine hydroxymethyltransferase and Organism(s) Homo sapiens and UniProt Accession P34896
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kruschwitz, H.; Ren, S.; Di Salvo, M.; Schifch, V.
Expression, purification, and characterization of human cytosolic serine hydroxymethyltransferase
Protein Expr. Purif.
6
411-416
1995
Homo sapiens
Appaji Rao, N.; Talwar, R.; Savithri, H.S.
Molecular organization, catalytic mechanism and function of serine hydroxymethyltransferase - a potential target for cancer chemotherapy
Int. J. Biochem. Cell Biol.
32
405-416
2000
Saccharomyces cerevisiae, Oryctolagus cuniculus, Escherichia coli, Ovis aries, Homo sapiens, Pisum sativum
Ogawa, H.; Gomi, T.; Fujioka, M.
Serine hydroxymethyltransferase and threonine aldolase: are they identical?
Int. J. Biochem. Cell Biol.
32
289-301
2000
Cricetulus griseus, Escherichia coli, Homo sapiens, Neurospora crassa, Oryctolagus cuniculus, Ovis aries, Pisum sativum, Rattus norvegicus, Vigna radiata
Chave, K.J.; Snell, K.; Sanders, P.G.
Isolation and characterization of human genomic sequences encoding cytosolic serine hydroxymethyltransferase
Biochem. Soc. Trans.
25
53S
1997
Homo sapiens
Liu, X.; Reig, B.; Nasrallah, I.M.; Stover, P.J.
Human cytoplasmic serine hydroxymethyltransferase is an mRNA binding protein
Biochemistry
39
11523-11531
2000
Homo sapiens
Lewis, R.M.; Godfrey, K.M.; Jackson, A.A.; Cameron, I.T.; Hanson, M.A.
Low serine hydroxymethyltransferase activity in the human placenta has important implications for fetal glycine supply
J. Clin. Endocrinol. Metab.
90
1594-1598
2005
Ovis aries, Homo sapiens, Rattus norvegicus
Agrawal, S.; Kumar, A.; Srivastava, V.; Mishra, B.N.
Cloning, expression, activity and folding studies of serine hydroxymethyltransferase: a target enzyme for cancer chemotherapy
J. Mol. Microbiol. Biotechnol.
6
67-75
2003
Escherichia coli, Homo sapiens
Fu, T.F.; Hunt, S.; Schirch, V.; Safo, M.K.; Chen, B.H.
Properties of human and rabbit cytosolic serine hydroxymethyltransferase are changed by single nucleotide polymorphic mutations
Arch. Biochem. Biophys.
442
92-101
2005
Homo sapiens, Oryctolagus cuniculus (P07511), Oryctolagus cuniculus
Perry, C.; Sastry, R.; Nasrallah, I.M.; Stover, P.J.
Mimosine attenuates serine hydroxymethyltransferase transcription by chelating zinc: implications for inhibition of DNA replication
J. Biol. Chem.
280
396-400
2005
Homo sapiens
Franca, T.C.; Wilter, A.; Ramalho, T.C.; Pascutti, P.G.; Figueroa-Villar, J.D.
Molecular dynamics of the interaction of Plasmodium falciparum and human serine hydroxymethyltransferase with 5-formyl-6-hydrofolic acid analogues: design of new potential antimalarials
J. Braz. Chem. Soc.
17
1383-1392
2006
Plasmodium falciparum, Homo sapiens (P34896)
-
Choi, M.
Human serine hydroxymethyltransferase 2 (SHMT2) interacts with hnRNP D
Genes Genomics
30
541-548
2008
Homo sapiens
-
Siglioccolo, A.; Bossa, F.; Pascarella, S.
Structural adaptation of serine hydroxymethyltransferase to low temperatures
Int. J. Biol. Macromol.
46
37-46
2010
Geobacillus stearothermophilus, Oryctolagus cuniculus, Escherichia coli, Homo sapiens, Mus musculus
Fox, J.T.; Stover, P.J.
Mechanism of the internal ribosome entry site-mediated translation of serine hydroxymethyltransferase 1
J. Biol. Chem.
284
31085-31096
2009
Homo sapiens
Fox, J.T.; Shin, W.K.; Caudill, M.A.; Stover, P.J.
A UV-responsive internal ribosome entry site enhances serine hydroxymethyltransferase 1 expression for DNA damage repair
J. Biol. Chem.
284
31097-31108
2009
Homo sapiens
Anderson, D.D.; Woeller, C.F.; Chiang, E.P.; Shane, B.; Stover, P.J.
Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis
J. Biol. Chem.
287
7051-7062
2012
Homo sapiens
Pinthong, C.; Maenpuen, S.; Amornwatcharapong, W.; Yuthavong, Y.; Leartsakulpanich, U.; Chaiyen, P.
Distinct biochemical properties of human serine hydroxymethyltransferase compared with the Plasmodium enzyme: implications for selective inhibition
FEBS J.
281
2570-2583
2014
Plasmodium falciparum, Plasmodium vivax, Homo sapiens (P34896), Homo sapiens
di Salvo, M.L.; Contestabile, R.; Paiardini, A.; Maras, B.
Glycine consumption and mitochondrial serine hydroxymethyltransferase in cancer cells: the heme connection
Med. Hypotheses
80
633-636
2013
Homo sapiens (P34897)
Kim, D.; Fiske, B.P.; Birsoy, K.; Freinkman, E.; Kami, K.; Possemato, R.L.; Chudnovsky, Y.; Pacold, M.E.; Chen, W.W.; Cantor, J.R.; Shelton, L.M.; Gui, D.Y.; Kwon, M.; Ramkissoon, S.H.; Ligon, K.L.; Kang, S.W.; Snuderl, M.; Vander Heiden, M.G.; Sabatini, D.M.
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
Nature
520
363-367
2015
Homo sapiens (P34897), Homo sapiens
Yin, K.
Positive correlation between expression level of mitochondrial serine hydroxymethyltransferase and breast cancer grade
OncoTargets Ther.
8
1069-1074
2015
Homo sapiens
Amornwatcharapong, W.; Maenpuen, S.; Chitnumsub, P.; Leartsakulpanich, U.; Chaiyen, P.
Human and Plasmodium serine hydroxymethyltransferases differ in rate-limiting steps and pH-dependent substrate inhibition behavior
Arch. Biochem. Biophys.
630
91-100
2017
Homo sapiens, Plasmodium vivax
Tramonti, A.; Nardella, C.; di Salvo, M.L.; Barile, A.; Cutruzzola, F.; Contestabile, R.
Human cytosolic and mitochondrial serine hydroxymethyltransferase isoforms in comparison full kinetic characterization and substrate inhibition properties
Biochemistry
57
6984-6996
2018
Homo sapiens (P34896), Homo sapiens (P34897), Homo sapiens
Paiardini, A.; Tramonti, A.; Schirch, D.; Guiducci, G.; di Salvo, M.L.; Fiascarelli, A.; Giorgi, A.; Maras, B.; Cutruzzola, F.; Contestabile, R.
Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming
Biochim. Biophys. Acta
1864
1506-1517
2016
Homo sapiens (P34896), Homo sapiens (P34897), Homo sapiens
Paiardini, A.; Fiascarelli, A.; Rinaldo, S.; Daidone, F.; Giardina, G.; Koes, D.R.; Parroni, A.; Montini, G.; Marani, M.; Paone, A.; McDermott, L.A.; Contestabile, R.; Cutruzzola, F.
Screening and in vitro testing of antifolate inhibitors of human cytosolic serine hydroxymethyltransferase
ChemMedChem
10
490-497
2015
Homo sapiens
Giardina, G.; Brunotti, P.; Fiascarelli, A.; Cicalini, A.; Costa, M.G.; Buckle, A.M.; di Salvo, M.L.; Giorgi, A.; Marani, M.; Paone, A.; Rinaldo, S.; Paiardini, A.; Contestabile, R.; Cutruzzola, F.
How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state
FEBS J.
282
1225-1241
2015
Homo sapiens (P34896), Homo sapiens (P34897), Homo sapiens
Giardina, G.; Paone, A.; Tramonti, A.; Lucchi, R.; Marani, M.; Magnifico, M.C.; Bouzidi, A.; Pontecorvi, V.; Guiducci, G.; Zamparelli, C.; Rinaldo, S.; Paiardini, A.; Contestabile, R.; Cutruzzola, F.
The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells
FEBS J.
285
3238-3253
2018
Homo sapiens (P34896)
