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Literature summary for 2.1.2.1 extracted from

  • Chave, K.J.; Snell, K.; Sanders, P.G.
    Isolation and characterization of human genomic sequences encoding cytosolic serine hydroxymethyltransferase (1997), Biochem. Soc. Trans., 25, 53S.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-serine + tetrahydrofolate Homo sapiens main glycine source for purine biosynthetic pathway in ureide biogenesis glycine + 5,10-methylenetetrahydrofolate + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine + tetrahydrofolate
-
Homo sapiens glycine + 5,10-methylenetetrahydrofolate + H2O
-
?
L-serine + tetrahydrofolate main glycine source for purine biosynthetic pathway in ureide biogenesis Homo sapiens glycine + 5,10-methylenetetrahydrofolate + H2O
-
?

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate one mol/subunit bound to the epsilon-amino group of lysine Homo sapiens
tetrahydrofolate
-
Homo sapiens