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(n-1)-alkanoate + NADPH + H+ + O2
(omega-1)-hydroxy-n-alkanoate + NADP+ + H2O
1,1-diethylcyclopropane + NADPH + H+ + O2
?
1,7-octadiene + NADH + H+ + O2
1,2-epoxy-7-octene + NAD+ + H2O
-
epoxidation of simple, aliphatic terminal olefins
-
-
?
1-hexadecene + reduced rubredoxin + O2
? + oxidized rubredoxin + H2O
-
-
-
-
?
1-octadecene + reduced rubredoxin + O2
? + oxidized rubredoxin + H2O
-
-
-
-
?
1-octene + reduced rubredoxin + O2
1,2-epoxyoctane + oxidized rubredoxin + H2O
2 1-octyne + 2 NADH + 2 H+ + 2 O2
1-octanoic acid + 7-octynoic acid + 2 NAD+ + 2 H2O
-
-
-
-
?
2,5-dimethylhexane + NADH + H+ + O2
?
-
-
-
-
?
5,8,11-eicosatrienoic acid + NAD(P)H + H+ + O2
? + NAD(P)+ + H2O
-
-
-
-
?
arachidonic acid + NAD(P)H + H+ + O2
(5Z,8Z,11Z,14Z)-20-hydroxyeicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
arachidonic acid + NAD(P)H + H+ + O2
20-hydroxyicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
arachidonic acid + NADPH + H+ + O2
20-hydroxyeicosatetraenoic acid + NADP+ + H2O
bicyclohexane + reduced rubredoxin + O2
? + oxidized rubredoxin + H2O
-
i.e. bicyclo[3.1.0]hexane, no distinction between the 2- and 3-positions, reaction via formation of a substrate radical that persists in the active site
-
-
?
butane + NADPH + H+ + O2
1-butanol + NADP+ + H2O
cycloheptane + NAD(P)H + H+ + O2
cycloheptanol + NAD(P)+ + H2O
cyclohexane + NAD(P)H + H+ + O2
cyclohexanol + NAD(P)+ + H2O
cyclohexane + NADH + H+ + O2
cyclohexanol + NAD+ + H2O
-
-
-
-
?
cyclooctane + NAD(P)H + H+ + O2
cyclooctanol + NAD(P)+ + H2O
cyclopentane + NAD(P)H + H+ + O2
cyclopentanol + NAD(P)+ + H2O
-
very poor substrate
-
-
?
decane + reduced rubredoxin + O2
1-decanol + oxidized rubredoxin + H2O
-
-
-
-
?
decane + reduced rubredoxin + O2 + H+
1-decanol + oxidized rubredoxin + H2O
-
-
-
-
r
dicyclopropylketone + NAD(P)H + H+ + O2
? + NAD(P)+ + H2O
-
-
-
?
docosahexaenoic acid + NAD(P)H + H+ + O2
? + NAD(P)+ + H2O
-
-
-
-
?
dodecane + reduced rubredoxin + O2
1-dodecanol + oxidized rubredoxin + H2O
-
-
-
-
?
eicosapentaenoic acid + NAD(P)H + H+ + O2
? + NAD(P)+ + H2O
-
is less omega-hydroxylated than 5,8,11-eicosatrienoic acid and arachidonic acid
-
-
?
ethyl tert-butyl ether + NAD(P)H + H+ + O2
tert-butyl-alcohol + NAD(P)+ + H2O + acetaldehyde
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
heptadecane + reduced rubredoxin + O2
1-heptadecanol + oxidized rubredoxin + H2O
-
-
-
-
?
heptanoate + NADPH + H+ + O2
?
-
59% activity compared to octane
-
-
r
hexadecane + reduced rubredoxin + O2
1-hexadecanol + oxidized rubredoxin + H2O
-
-
-
-
?
hexane + reduced rubredoxin + O2
1-hexanol + oxidized rubredoxin + H2O
-
-
-
-
?
hexane + reduced rubredoxin + O2 + H+
1-hexanol + oxidized rubredoxin + H2O
-
-
-
-
r
hexanoate + NADPH + H+ + O2
?
-
25% activity compared to octane
-
-
r
lauric acid + NAD(P)H + H+ + O2
12-hydroxydodecanoic acid + NAD(P)+ + H2O
lauric acid + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxydodecanoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
lecithin + NADH + H+ + O2
?
-
-
-
-
?
methane + NADPH + H+ + O2
methanol + NADP+ + H2O
methane sulfonic acid + reduced rubredoxin + O2
? + oxidized rubredoxin + H2O
-
-
-
-
?
methyl tert-butyl ether + NAD(P)H + H+ + O2
tert-butyl-alcohol + NAD(P)+ + H2O
methyl tert-butyl ether + NAD(P)H + H+ + O2
tert-butyl-alcohol + NAD(P)+ + H2O + formaldehyde
methyl tert-butyl ether + NAD(P)H + H+ + O2
tert-butyl-alcohol + NAD(P)+ + H2O + methanol
-
-
-
?
methylcyclohexane + NADH + H+ + O2
?
-
-
-
-
?
methylphenylcyclopropane + reduced rubredoxin + O2
1-phenylbut-3-en-1-ol + oxidized rubredoxin + H2O
-
reaction via formation of a substrate radical that persists in the active site
-
-
?
monoolein + NADH + H+ + O2
18-hydroxyoctadec-9-enoic acid 2,3-dihydroxypropyl ester + NAD+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
n-alkane + NADPH + H+ + O2
n-alkanol + NADP+ + H2O
n-butane + NADPH + H+ + O2
n-butanol + NADP+ + H2O
n-butane + reduced rubredoxin + O2
1-butanol + oxidized rubredoxin + H2O
n-dodecane + 2 reduced rubredoxin + O2 + 2 H+
1-dodecanol + 2 oxidized rubredoxin + H2O
n-hexadecane + NADPH + H+ + O2
n-hexadecanol + NADP+ + H2O
n-octane + NADH + H+ + O2
n-octanol + NAD+ + H2O
n-octane + reduced rubredoxin + O2
n-octanol + oxidized rubredoxin + H2O
n-propane + reduced rubredoxin + O2
1-propanol + oxidized rubredoxin + H2O
nitromethane + reduced rubredoxin + O2
? + oxidized rubredoxin + H2O
-
-
-
-
?
nonanoate + NADPH + H+ + O2
?
-
25% activity compared to octane
-
-
r
norcarane + NADPH + H+ + O2
?
norcarane + reduced rubredoxin + O2
? + oxidized rubredoxin + H2O
-
i.e. bicyclo[4.1.0]heptane, oxidation preferentially occurs at the less sterically hindered 3-position, reaction via formation of a substrate radical that persists in the active site
-
-
?
octadecane + reduced rubredoxin + O2
1-octadecanol + oxidized rubredoxin + H2O
-
-
-
-
?
octane + reduced rubredoxin + O2
1-octanol + oxidized rubredoxin + H2O
palmitic acid + NAD(P)H + H+ + O2
16-hydroxyhexadecanoic acid + NAD(P)+ + H2O
pentadecane + reduced rubredoxin + O2
1-pentadecanol + oxidized rubredoxin + H2O
-
best substrate
-
-
?
pentane + reduced rubredoxin + O2
1-pentanol + oxidized rubredoxin + H2O
-
-
-
-
?
phosphatidylethanolamine + NADH + H+ + O2
?
-
-
-
-
?
phosphatidylserine + NADH + H+ + O2
?
-
-
-
-
?
propane + NADPH + H+ + O2
1-propanol + NADP+ + H2O
propane + NADPH + H+ + O2
propan-1-ol + NADP+ + H2O
Q08KD8; Q08KD7 and Q08KD6; Q08KD5, Q08KE2; Q08KE1 and Q08KE0; Q08KD9 -
-
-
?
propane + NADPH + H+ + O2
propanol + NADP+ + H2O
prostaglandin A1 + [reduced NADPH-hemoprotein reductase] + O2
?
prostaglandin A2 + NADPH + O2
?
-
-
-
-
?
prostaglandin E1 + NADPH + O2
?
-
-
-
-
?
spirooctane + NADPH + H+ + O2
?
stearic acid + NAD(P)H + H+ + O2
? + NAD(P)+ + H2O
-
-
-
-
?
suberin + NADPH + H+ + O2
? + NADP+ + H2O
-
-
-
?
tert-amyl methyl ether + NAD(P)H + H+ + O2
tert-amyl-alcohol + NAD(P)+ + H2O + formaldehyde
tetracosane + reduced rubredoxin + O2
1-tetracosanol + oxidized rubredoxin + H2O
-
-
-
-
?
additional information
?
-
(n-1)-alkanoate + NADPH + H+ + O2
(omega-1)-hydroxy-n-alkanoate + NADP+ + H2O
-
-
-
-
?
(n-1)-alkanoate + NADPH + H+ + O2
(omega-1)-hydroxy-n-alkanoate + NADP+ + H2O
-
-
-
-
?
(n-1)-alkanoate + NADPH + H+ + O2
(omega-1)-hydroxy-n-alkanoate + NADP+ + H2O
-
-
-
-
?
(n-1)-alkanoate + NADPH + H+ + O2
(omega-1)-hydroxy-n-alkanoate + NADP+ + H2O
-
-
-
-
?
(n-1)-alkanoate + NADPH + H+ + O2
(omega-1)-hydroxy-n-alkanoate + NADP+ + H2O
-
chain length C10-C16
-
-
?
1,1-diethylcyclopropane + NADPH + H+ + O2
?
-
-
-
-
?
1,1-diethylcyclopropane + NADPH + H+ + O2
?
-
-
-
-
?
1-octene + reduced rubredoxin + O2
1,2-epoxyoctane + oxidized rubredoxin + H2O
epoxidation reaction catalysed by AlkB
-
-
?
1-octene + reduced rubredoxin + O2
1,2-epoxyoctane + oxidized rubredoxin + H2O
epoxidation reaction catalysed by AlkB
-
-
?
arachidonic acid + NAD(P)H + H+ + O2
(5Z,8Z,11Z,14Z)-20-hydroxyeicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
-
-
-
-
?
arachidonic acid + NAD(P)H + H+ + O2
(5Z,8Z,11Z,14Z)-20-hydroxyeicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
-
product formation relaxes distal human pulmonary arteries
-
-
?
arachidonic acid + NAD(P)H + H+ + O2
(5Z,8Z,11Z,14Z)-20-hydroxyeicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
-
the rate of metabolism by CYPA11 P450 is 10-100fold less as compared to lauric acid
-
-
?
arachidonic acid + NAD(P)H + H+ + O2
(5Z,8Z,11Z,14Z)-20-hydroxyeicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
-
-
-
-
?
arachidonic acid + NAD(P)H + H+ + O2
(5Z,8Z,11Z,14Z)-20-hydroxyeicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
-
-
-
-
?
arachidonic acid + NAD(P)H + H+ + O2
20-hydroxyicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
-
-
-
-
?
arachidonic acid + NAD(P)H + H+ + O2
20-hydroxyicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
-
-
-
-
?
arachidonic acid + NAD(P)H + H+ + O2
20-hydroxyicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
-
-
-
-
?
arachidonic acid + NADPH + H+ + O2
20-hydroxyeicosatetraenoic acid + NADP+ + H2O
-
-
-
-
?
arachidonic acid + NADPH + H+ + O2
20-hydroxyeicosatetraenoic acid + NADP+ + H2O
-
-
-
-
?
arachidonic acid + NADPH + H+ + O2
20-hydroxyeicosatetraenoic acid + NADP+ + H2O
-
-
-
-
?
butane + NADPH + H+ + O2
1-butanol + NADP+ + H2O
-
-
-
-
?
butane + NADPH + H+ + O2
1-butanol + NADP+ + H2O
-
-
-
-
?
cycloheptane + NAD(P)H + H+ + O2
cycloheptanol + NAD(P)+ + H2O
-
-
-
-
?
cycloheptane + NAD(P)H + H+ + O2
cycloheptanol + NAD(P)+ + H2O
-
-
-
-
?
cyclohexane + NAD(P)H + H+ + O2
cyclohexanol + NAD(P)+ + H2O
-
-
-
-
?
cyclohexane + NAD(P)H + H+ + O2
cyclohexanol + NAD(P)+ + H2O
-
-
-
-
?
cyclooctane + NAD(P)H + H+ + O2
cyclooctanol + NAD(P)+ + H2O
-
poor substrate
-
-
?
cyclooctane + NAD(P)H + H+ + O2
cyclooctanol + NAD(P)+ + H2O
-
poor substrate
-
-
?
ethyl tert-butyl ether + NAD(P)H + H+ + O2
tert-butyl-alcohol + NAD(P)+ + H2O + acetaldehyde
-
-
-
-
?
ethyl tert-butyl ether + NAD(P)H + H+ + O2
tert-butyl-alcohol + NAD(P)+ + H2O + acetaldehyde
-
-
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
-
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
protein from CYP52A3 has a higher affinity for fatty acids than for alkanes
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
high affinity for short chain fatty acids
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
protein from CYP52A3 has a higher affinity for fatty acids than for alkanes
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
-
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
-
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
-
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
NADPH-P-450 reductase and omega-hydrolase are 1 protein
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
-
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
-
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
pig liver NADPH-P450 reductase and cytochrome b5 are part of the system
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
3D-structure analysis, substrate pocket determination
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
medium-chain fatty acids
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
chain length C12-C16, arachidonic acid and oleic acid
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
-
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
-
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
laurate and arachidonic acid
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
chain length C10-C19
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
NADPH-P450 reductase and cytochrome b5 are part of the enzyme system
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
-
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
chain length C6-C14
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
chain length C6-C11, maximal activity with heptanoate
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
-
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
-
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
chain length C12-C16, arachidonic acid and oleic acid
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
-
-
-
?
fatty acid + NAD(P)H + H+ + O2
omega-hydroxy fatty acid + NAD(P)+ + H2O
-
-
-
-
?
lauric acid + NAD(P)H + H+ + O2
12-hydroxydodecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
lauric acid + NAD(P)H + H+ + O2
12-hydroxydodecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
lauric acid + NAD(P)H + H+ + O2
12-hydroxydodecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
lauric acid + NAD(P)H + H+ + O2
12-hydroxydodecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
lauric acid + NAD(P)H + H+ + O2
12-hydroxydodecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
lauric acid + NAD(P)H + H+ + O2
12-hydroxydodecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
lauric acid + NAD(P)H + H+ + O2
12-hydroxydodecanoic acid + NAD(P)+ + H2O
-
CYPA11 P450 efficiently and selectively omega-hydroxylates lauric acid
-
-
?
lauric acid + NAD(P)H + H+ + O2
12-hydroxydodecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
lauric acid + NAD(P)H + H+ + O2
12-hydroxydodecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
lauric acid + NAD(P)H + H+ + O2
12-hydroxydodecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
lauric acid + NAD(P)H + H+ + O2
12-hydroxydodecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
methane + NADPH + H+ + O2
methanol + NADP+ + H2O
-
-
-
-
?
methane + NADPH + H+ + O2
methanol + NADP+ + H2O
-
-
-
-
?
methyl tert-butyl ether + NAD(P)H + H+ + O2
tert-butyl-alcohol + NAD(P)+ + H2O
-
-
-
-
?
methyl tert-butyl ether + NAD(P)H + H+ + O2
tert-butyl-alcohol + NAD(P)+ + H2O
-
-
-
-
?
methyl tert-butyl ether + NAD(P)H + H+ + O2
tert-butyl-alcohol + NAD(P)+ + H2O + formaldehyde
-
-
-
-
?
methyl tert-butyl ether + NAD(P)H + H+ + O2
tert-butyl-alcohol + NAD(P)+ + H2O + formaldehyde
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
protein from CYP52A3 has a higher affinity for alkanes than for fatty acids
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
protein from CYP52A3 has a higher affinity for alkanes than for fatty acids
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
acts on C5-C13 alkanes, highest activity with n-hexane
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
acts on C5-C13 alkanes, highest activity with n-hexane
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
oxidizes C10-C16 alkanes
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
oxidizes C10-C16 alkanes
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
alkanes above C6
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
alkanes above C6
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
rubredoxin is electron carrier
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
chain length C6-C14
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
chain length C6-C16, maximal activity with n-octane
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
possible role in compensating low hydrocarbon concentrations
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
native strain oxidizes C6-C13 alkanes
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
oxidizes C5-C12 alkanes
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
possible role in compensating low hydrocarbon concentrations
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
oxidizes C5-C12 alkanes
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
native strain oxidizes C6-C13 alkanes
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
?
n-alkane + NAD(P)H + H+ + O2
n-alkanol + NAD(P)+ + H2O
-
-
-
-
?
n-alkane + NADPH + H+ + O2
n-alkanol + NADP+ + H2O
-
-
-
-
?
n-alkane + NADPH + H+ + O2
n-alkanol + NADP+ + H2O
-
initial activation of alkanes
-
-
?
n-alkane + NADPH + H+ + O2
n-alkanol + NADP+ + H2O
-
-
-
-
?
n-alkane + NADPH + H+ + O2
n-alkanol + NADP+ + H2O
-
-
-
-
?
n-butane + NADPH + H+ + O2
n-butanol + NADP+ + H2O
-
-
-
-
?
n-butane + NADPH + H+ + O2
n-butanol + NADP+ + H2O
-
-
-
-
?
n-butane + NADPH + H+ + O2
n-butanol + NADP+ + H2O
-
-
-
-
?
n-butane + reduced rubredoxin + O2
1-butanol + oxidized rubredoxin + H2O
-
-
-
-
?
n-butane + reduced rubredoxin + O2
1-butanol + oxidized rubredoxin + H2O
-
-
-
-
?
n-dodecane + 2 reduced rubredoxin + O2 + 2 H+
1-dodecanol + 2 oxidized rubredoxin + H2O
-
-
-
?
n-dodecane + 2 reduced rubredoxin + O2 + 2 H+
1-dodecanol + 2 oxidized rubredoxin + H2O
-
-
-
?
n-hexadecane + NADPH + H+ + O2
n-hexadecanol + NADP+ + H2O
-
-
-
-
?
n-hexadecane + NADPH + H+ + O2
n-hexadecanol + NADP+ + H2O
-
-
-
-
?
n-hexadecane + NADPH + H+ + O2
n-hexadecanol + NADP+ + H2O
-
NADPH-cyt P-450-reductase
-
-
?
n-hexadecane + NADPH + H+ + O2
n-hexadecanol + NADP+ + H2O
-
NADPH-cyt P-450-reductase
-
-
?
n-hexadecane + NADPH + H+ + O2
n-hexadecanol + NADP+ + H2O
-
-
-
-
?
n-hexadecane + NADPH + H+ + O2
n-hexadecanol + NADP+ + H2O
-
-
-
-
?
n-octane + NADH + H+ + O2
n-octanol + NAD+ + H2O
-
cytochrome P450 is electron carrier
-
-
?
n-octane + NADH + H+ + O2
n-octanol + NAD+ + H2O
-
cytochrome P450 is electron carrier
-
-
?
n-octane + NADH + H+ + O2
n-octanol + NAD+ + H2O
-
-
-
-
?
n-octane + reduced rubredoxin + O2
n-octanol + oxidized rubredoxin + H2O
-
-
-
-
?
n-octane + reduced rubredoxin + O2
n-octanol + oxidized rubredoxin + H2O
-
-
-
-
?
n-octane + reduced rubredoxin + O2
n-octanol + oxidized rubredoxin + H2O
-
-
-
-
?
n-propane + reduced rubredoxin + O2
1-propanol + oxidized rubredoxin + H2O
-
-
-
-
?
n-propane + reduced rubredoxin + O2
1-propanol + oxidized rubredoxin + H2O
-
-
-
-
?
norcarane + NADPH + H+ + O2
?
-
-
-
-
?
norcarane + NADPH + H+ + O2
?
-
-
-
-
?
octane + reduced rubredoxin + O2
1-octanol + oxidized rubredoxin + H2O
-
-
-
-
?
octane + reduced rubredoxin + O2
1-octanol + oxidized rubredoxin + H2O
-
-
-
-
?
octane + reduced rubredoxin + O2
1-octanol + oxidized rubredoxin + H2O
-
-
-
-
?
octane + reduced rubredoxin + O2
1-octanol + oxidized rubredoxin + H2O
-
-
-
-
?
palmitic acid + NAD(P)H + H+ + O2
16-hydroxyhexadecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
palmitic acid + NAD(P)H + H+ + O2
16-hydroxyhexadecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
palmitic acid + NAD(P)H + H+ + O2
16-hydroxyhexadecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
palmitic acid + NAD(P)H + H+ + O2
16-hydroxyhexadecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
palmitic acid + NAD(P)H + H+ + O2
16-hydroxyhexadecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
palmitic acid + NAD(P)H + H+ + O2
16-hydroxyhexadecanoic acid + NAD(P)+ + H2O
-
CYPA11 P450 shows less selectivity in the metabolism of palmitic acid where both omega and omega-1 products are produced
-
-
?
palmitic acid + NAD(P)H + H+ + O2
16-hydroxyhexadecanoic acid + NAD(P)+ + H2O
-
-
-
-
?
propane + NADPH + H+ + O2
1-propanol + NADP+ + H2O
-
-
-
-
?
propane + NADPH + H+ + O2
1-propanol + NADP+ + H2O
Q08KD8; Q08KD7 and Q08KD6; Q08KD5, Q08KE2; Q08KE1 and Q08KE0; Q08KD9 -
-
-
?
propane + NADPH + H+ + O2
propanol + NADP+ + H2O
-
-
-
-
?
propane + NADPH + H+ + O2
propanol + NADP+ + H2O
-
-
-
-
?
prostaglandin A1 + [reduced NADPH-hemoprotein reductase] + O2
?
-
-
-
-
?
prostaglandin A1 + [reduced NADPH-hemoprotein reductase] + O2
?
-
-
-
-
?
spirooctane + NADPH + H+ + O2
?
-
-
-
-
?
spirooctane + NADPH + H+ + O2
?
-
-
-
-
?
tert-amyl methyl ether + NAD(P)H + H+ + O2
tert-amyl-alcohol + NAD(P)+ + H2O + formaldehyde
-
-
-
-
?
tert-amyl methyl ether + NAD(P)H + H+ + O2
tert-amyl-alcohol + NAD(P)+ + H2O + formaldehyde
-
-
-
-
?
additional information
?
-
-
substrates are alkanes of chain length C8 to C12
-
-
?
additional information
?
-
-
AbAlkB can catalyze the hydroxylation of a large number of aromatic compounds and linear and cyclic alkanes. It does not catalyze the hydroxylation of alkanes with a chain length longer than 15 carbons, nor does it hydroxylate sterically hindered C-H bonds. GC-MS product analysis, overview. AbAlkB hydroxylates the terminal methyl group of medium chain alkanes, where octane is apparently close to the optimal chain length
-
-
?
additional information
?
-
-
20-hydroxyeicosatetraenoic acid modulates renal transport activities
-
-
?
additional information
?
-
-
CYP4A prefers to metabolize medium chain fatty acids (C10-C16)
-
-
?
additional information
?
-
-
CYP4A prefers to metabolize medium chain fatty acids (C10C16)
-
-
?
additional information
?
-
-
substrates are alkanes of chain length C10 to C16
-
-
?
additional information
?
-
-
substrates are alkanes of chain length C10 to C16
-
-
?
additional information
?
-
-
substrates are alkanes of chain length C12 to C16
-
-
?
additional information
?
-
-
substrates of one isoform are alkanes of chain length C12 to C16, the second isoform hydroxylates octadecan or eicosan
-
-
?
additional information
?
-
-
the enzyme also catalyzes the oxygenative O-demethylation of ethers, the sulfoxidation of methyl sulfides and the stereoselective epoxidation of terminal olefins
-
-
?
additional information
?
-
-
physiological role of enzyme complex is to initiate the monoterminal oxidation of alkane chains
-
-
?
additional information
?
-
-
does not catalyze the hydroxylation of 1,1-dimethylcyclopropane or 1,1,2,2-tetramethylcyclopropane
-
-
?
additional information
?
-
-
AlkB, a nonheme diiron monooxygenase, performs regioselectibe hydroxylation of gem-difluorinated octanes, synthesis of 2,2-, 3,3- and 4,4-difluorooctan-1-ols from 1-octanal and 2-, 3-, 4-octanones, NMR and GC/MS product analysis, overview. Reactions of AlkB with 3,3- and 4,4-difluorooctanes and 1,1,1-trifluoroctane, synthesis of 2,2-, 3,3- 4,4-difluorooctan-1-ols, and of 8,8-, 7,7-, 6,6- and 5,5-difluorooctan-1-ols, overview
-
-
?
additional information
?
-
-
does not catalyze the hydroxylation of 1,1-dimethylcyclopropane or 1,1,2,2-tetramethylcyclopropane
-
-
?
additional information
?
-
-
AlkB, a nonheme diiron monooxygenase, performs regioselectibe hydroxylation of gem-difluorinated octanes, synthesis of 2,2-, 3,3- and 4,4-difluorooctan-1-ols from 1-octanal and 2-, 3-, 4-octanones, NMR and GC/MS product analysis, overview. Reactions of AlkB with 3,3- and 4,4-difluorooctanes and 1,1,1-trifluoroctane, synthesis of 2,2-, 3,3- 4,4-difluorooctan-1-ols, and of 8,8-, 7,7-, 6,6- and 5,5-difluorooctan-1-ols, overview
-
-
?
additional information
?
-
-
substrate specificity of the alkane hydroxylase large subunit, overview. Poor activity with 1-tetradecanol, no activity with octacosane, benzene, sodium benzoate, toluene, catechol, biphenyl, 1-hexadecanol, 1-stearyl alcohol, isooctane, pristine, and squalane
-
-
?
additional information
?
-
dodecane strongly binds to Cyp153D17 with similar Kd values as C10-C12 fatty acids
-
-
?
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Peterson, J.A.; Kusunose, M.; Kusunose, E.; Coon, M.J.
Enzymatic omega-oxidation. II. Function of rubredoxin as the electron carrier in omega-hydroxylation
J. Biol. Chem.
242
4334-4340
1967
Pseudomonas oleovorans
brenda
Cardini, G.; Jurtshuk, P.
The enzymatic hydroxylation of n-octane by Corybacterium sp. strain 7E1C
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2789-2796
1970
Corynebacterium sp., Corynebacterium sp. 7E1C
brenda
McKenna, E.J.; Coon, M.J.
Enzymatic omega-oxidation. IV. Purification and properties of the omega-hydroxylase of Pseudomonas oleovorans
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1970
Pseudomonas oleovorans
brenda
Ruettiger, R.T.; Olson, S.T.; Boyer, R.F.; Coon, M.J.
Identification of the omega-hydroxylase of Pseudomonas oleovorans as a nonheme iron protein requiring phospholipid for catalytic activity
Biochem. Biophys. Res. Commun.
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1974
Pseudomonas oleovorans
brenda
Ruettinger, R.T.; Griffith, G.R.; Coon, M.J.
Characterization of the omega-hydroxylase of Pseudomonas oleovorans as a nonheme iron protein
Arch. Biochem. Biophys.
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1977
Pseudomonas oleovorans
brenda
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Fatty acid omega-hydroxylase (alkane hydroxylase) from Pseudomonas oleovorans
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1978
Pseudomonas oleovorans
brenda
Matsuyama, H.; Nakahara, T.; Minoda, Y.
A new n-alkane oxidation system from Pseudomonas aeruginosa S7B1
Agric. Biol. Chem.
45
9-14
1981
Pseudomonas aeruginosa, Pseudomonas aeruginosa S7B1
-
brenda
Honeck, H.; Schunck, W.H.; Riege, P.; Muller, H.G.
The cytochrome P-450 alkane monooxygenase system of the yeast Lodderomyces elongisporus: purification and some properties of the NADPH-cytochrome P-450 reductase
Biochem. Biophys. Res. Commun.
106
1318-1324
1982
Lodderomyces elongisporus, Lodderomyces elongisporus EH15D
brenda
Schnuck, W.H.; Riege, P.; Honeck, H.; Muller, H.G.
Isolierung und Rekonstitution des Alkan-Monooxygenase-Systems der Hefe Lodderomyces elongisporus
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1983
Lodderomyces elongisporus, Lodderomyces elongisporus EH15D
-
brenda
May, S.W.; Katopodis, A.G.
Hydrocarbon monooxygenase system of Pseudomonas oleovorans
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188
3-9
1990
Pseudomonas oleovorans
brenda
Sawamura, A.; Kusunose, E.; Satouchi, K.; Kusunose, M.
Catalytic properties of rabbit kidney fatty acid omega-hydroxylase cytochrome P-450ka2 (CYP4A7)
Biochim. Biophys. Acta
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30-36
1993
Oryctolagus cuniculus
brenda
Palmer, C.N.A.; Richardson, T.H.; Griffin, K.J.; Hsu, M.H.; Muerhoff, A.S.; Clark, J.E.; Johnson, E.F.
Characterization of a cDNA encoding a human kidney cytochrome P-450 4A fatty acid omega-hydroxylase and the cognate enzyme expressed in Escherichia coli
Biochim. Biophys. Acta
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161-166
1993
Homo sapiens
brenda
Nakayama, N.; Shoun, H.
Fatty acid hydroxylase of the fungus Fusarium oxysporum is possibly a fused protein of cytochrome P-450 and its reductase
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202
586-590
1994
Fusarium oxysporum
brenda
Scheller, U.; Zimmer, T.; Kaergel, E.; Schunck, W.H.
Characterization of the n-alkane and fatty acid hydroxylating cytochrome P450 forms 52A3 and 52A4
Arch. Biochem. Biophys.
328
245-254
1996
Candida maltosa, Candida maltosa EH15
brenda
Nakayama, N.; Takemae, A.; Shoun, H.
Cytochrome P450foxy, a catalytically self-sufficient fatty acid hydroxylase of the fungus Fusarium oxysporum
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119
435-440
1996
Fusarium oxysporum, Fusarium oxysporum MT-811
brenda
Helvig, C.; Alayrac, C.; Mioskowski, C.; Koop, D.; Poullain, D.; Durst, F.; Salaun, J.P.
Suicide inactivation of cytochrome P450 by midchain and terminal acetylenes. A mechanistic study of inactivation of a plant lauric acid omega-hydroxylase
J. Biol. Chem.
272
414-421
1997
Oryctolagus cuniculus, Vicia sativa
brenda
Koike, K.; Kusunose, E.; Nishikawa, Y.; Ichihara, K.; Inagaki, S.; Takagi, H.; Kikuta, Y.; Kusunose, M.
Purification and characterization of rabbit small intestinal cytochromes P450 belonging to CYP2J and CYP4A subfamilies
Biochem. Biophys. Res. Commun.
232
643-647
1997
Oryctolagus cuniculus
brenda
Zimmer, T.; Iida, T.; Schunck, W.H.; Yoshida, Y.; Ohta, A.; Takagi, M.
Relation between evolutionary distance and enzymic properties among the members of the CYP52A subfamily of Candida maltosa
Biochem. Biophys. Res. Commun.
251
244-247
1998
Candida maltosa
brenda
Dierks, E.A.; Davis, S.C.; Ortiz de Montellano, P.R.
Glu-325 and Asp-328 are determinants of the cyp4A1 hydroxylation regiospecificity and resistance to inactivation by 1-aminobenzotriazole
Biochemistry
37
1839-1847
1998
Homo sapiens
brenda
Goswami, P.; Cooney, J.J.
Subcellular location of enzymes involved in oxidation of n-alkane by Cladosporium resinae
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51
860-864
1999
Amorphotheca resinae, Amorphotheca resinae ATCC 22711
-
brenda
Chang, Y.T.; Loew, G.H.
Homology modeling and substrate binding study of human CYP4A11 enzyme
Proteins
34
403-415
1999
Homo sapiens
brenda
Hoch, U.; Zhang, Z.; Kroetz, D.L.; Ortiz de Montellano, P.R.
Structural determination of the substrate specificities and regioselectivities of the rat and human fatty acid omega-hydroxylases
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373
63-71
2000
Homo sapiens, Rattus norvegicus
brenda
Kawashima, H.; Naganuma, T.; Kusunose, E.; Kono, T.; Yasumoto, R.; Sugimura, K.; Kishimoto, T.
Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein
Arch. Biochem. Biophys.
378
333-339
2000
Homo sapiens
brenda
Loughran, P.A.; Roman, L.J.; Aitken, A.E.; Miller, R.T.; Masters, B.S.
Identification of unique amino acids that modulate CYP4A7 activity
Biochemistry
39
15110-15120
2000
Oryctolagus cuniculus
brenda
Hamamura, N.; Yeager, C.M.; Arp, D.J.
Two distinct monooxygenases for alkane oxidation in Nocardioides sp. strain CF8
Appl. Environ. Microbiol.
67
4992-4998
2001
Nocardioides sp., Nocardioides sp. CF8
brenda
Whyte, L.G.; Smits, T.H.; Labbe, D.; Witholt, B.; Greer, C.W.; van Beilen, J.B.
Gene cloning and characterization of multiple alkane hydroxylase systems in Rhodococcus strains Q15 and NRRL B-16531
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68
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