Reference on EC 1.13.11.6 - 3-hydroxyanthranilate 3,4-dioxygenase
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Decker, R.H.; Kang, H.H.; Leach, F.R.; Henderson, L.M.
Purification and properties of 3-hydroxyanthranilic acid oxidase
J. Biol. Chem.
236
3076-3082
1961
Bos taurus
Koontz, W.A.; Shiman, R.
Beef kidney 3-hydroxyanthranilic acid oxygenase. Purification, characterization, and analysis of the assay
J. Biol. Chem.
251
368-377
1976
Bos taurus
Foster, A.C.; White, R.J.; Schwarcz, R.
Synthesis of quinolinic acid by 3-hydroxyanthranilic acid oxygenase in rat brain tissue in vitro
J. Neurochem.
47
23-30
1986
BRENDA: Rattus norvegicus
Textmining: Rattus
Okuno, E.; Khler, C.; Schwarcz, R.
Rat 3-hydroxyanthranilic acid oxygenase: purification from the liver and immunocytochemical localization in the brain
J. Neurochem.
49
771-780
1987
BRENDA: Rattus norvegicus
Textmining: Rattus
Walsh, J.L.; Todd, W.P.; Carpenter, B.K.; Schwarcz, R.
4-Halo-3-hydroxyanthranilic acids: potent competitive inhibitors of 3-hydroxy-anthranilic acid oxygenase in vitro
Biochem. Pharmacol.
42
985-990
1991
Rattus norvegicus
Serrano, A.E.; Nagayama, F.
Liver 3-hydroxyanthranilic acid oxygenase activity in rainbow trout (Oncorhynchus mykiss)
Comp. Biochem. Physiol. B
99
275-280
1991
BRENDA: Oncorhynchus mykiss
Textmining: Chondrichthyes, Metazoa
Savage, N.; Levy, P.R.
The purification and some properties of 3-hydroxyanthranilate oxygenase from baboon liver
Int. J. Biochem.
6
459-466
1975
Papio ursinus
-
Malherbe, P.; Koehler, C.; Da Prada, M.; Lang, G.; Kiefer, V.; Schwarcz, R.; Lahm, H.W.; Cesura, A.M.
Molecular cloning and functional expression of human 3-hydroxyanthranilic-acid dioxygenase
J. Biol. Chem.
269
13792-13797
1994
BRENDA: Rattus norvegicus
Textmining: Homo sapiens, Rattus, insertion sequences
Roberts, R.C.; McCarthy, K.E.; Du, F.; Okuno, E.; Schwarcz, R.
Immunocytochemical localization of the quinolinic acid synthesizing enzyme, 3-hydroxyanthranilic acid oxygenase, in the rat substantia nigra
Brain Res.
650
229-238
1994
BRENDA: Rattus norvegicus
Textmining: Rattus, Electron
Fornstedt-Wallin, B.; Lundstrom, J.; Fredriksson, G.; Schwarcz, R.; Luthman, J.
3-Hydroxyanthranilic acid accumulation following administration of the 3-hydroxyanthranilic acid 3,4-dioxygenase inhibitor NCR-631
Eur. J. Pharmacol.
386
15-24
1999
Rattus norvegicus
Roberts, R.C.; McCarthy, K.E.; Du, F.; Ottersen, O.P.; Okuno, E.; Schwarcz, R.
3-Hydroxyanthranilic acid oxygenase-containing astrocytic processes surround glutamate-containing axon terminals in the rat striatum
J. Neurosci.
15
1150-1161
1995
BRENDA: Rattus norvegicus
Textmining: Rattus, Electron
Cesura, A.M.; Alberati-Giani, D.; Buchli, R.; Broger, C.; Kohler, C.; Vilbois, F.; Lahm, H.W.; Heitz, M.P.; Malherbe, P.
Molecular characterization of kynurenine pathway enzymes: 3-Hydroxyanthranilic-acid dioxygenase and kynurenine aminotransferase
Adv. Exp. Med. Biol.
398
477-483
1996
Rattus norvegicus
Chiarugi, A.; Moroni, F.
Effects of mitochondria and o-methoxybenzoylalanine on 3-hydroxyanthranilic acid dioxygenase activity and quinolinic acid synthesis
J. Neurochem.
72
1125-1132
1999
Mus musculus
Calderone, V.; Trabucco, M.; Menin, V.; Negro, A.; Zanotti, G.
Cloning of human 3-hydroxyanthranilic acid dioxygenase in Escherichia coli: characterisation of the purified enzyme and its in vitro inhibition by Zn2+
Biochim. Biophys. Acta
1596
283-292
2002
BRENDA: Homo sapiens
Textmining: Escherichia coli
Agrawal, V.K.; Sohgaura, R.; Khadikar, P.V.
QSAR study on inhibition of brain 3-hydroxy-anthranilic acid dioxygenase (3-HAO): a molecular connectivity approach
Bioorg. Med. Chem.
9
3295-3299
2001
BRENDA: Rattus norvegicus
Textmining: Rattus
Kucharczyk, R.; Zagulski, M.; Rytka, J.; Herbert, C.J.
The yeast gene YJR025c encodes a 3-hydroxyanthranilic acid dioxygenase and is involved in nicotinic acid biosynthesis
FEBS Lett.
424
127-130
1998
BRENDA: Escherichia coli, Saccharomyces cerevisiae (P47096), Saccharomyces cerevisiae
Textmining: Homo sapiens
Muraki, T.; Taki, M.; Hasegawa, Y.; Iwaki, H.; Lau, P.C.
Prokaryotic homologs of the eukaryotic 3-hydroxyanthranilate 3,4-dioxygenase and 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase in the 2-nitrobenzoate degradation pathway of Pseudomonas fluorescens strain KU-7
Appl. Environ. Microbiol.
69
1564-1572
2003
BRENDA: Pseudomonas fluorescens (Q83V26), Pseudomonas fluorescens, Pseudomonas fluorescens KU-7 (Q83V26)
Textmining: Escherichia coli, Pseudomonas sp.
Allegri, G.; Bertazzo, A.; Biasiolo, M.; Costa, C.V.; Ragazzi, E.
Kynurenine pathway enzymes in different species of animals
Adv. Exp. Med. Biol.
527
455-463
2003
Oryctolagus cuniculus, Mus sp., Rattus, Cavia
Nandi, D.; Lightcap, E.S.; Koo, Y.K.; Lu, X.; Quancard, J.; Silverman, R.B.
Purification and inactivation of 3-hydroxyanthranilic acid 3,4-dioxygenase from beef liver
Int. J. Biochem. Cell Biol.
35
1085-1097
2003
Bos taurus
Colabroy, K.L.; Zhai, H.; Li, T.; Ge, Y.; Zhang, Y.; Liu, A.; Ealick, S.E.; McLafferty, F.W.; Begley, T.P.
The mechanism of inactivation of 3-hydroxyanthranilate-3,4-dioxygenase by 4-chloro-3-hydroxyanthranilate
Biochemistry
44
7623-7631
2005
Cupriavidus metallidurans
Zhang, Y.; Colabroy, K.L.; Begley, T.P.; Ealick, S.E.
Structural studies on 3-hydroxyanthranilate-3,4-dioxygenase: the catalytic mechanism of a complex oxidation involved in NAD biosynthesis
Biochemistry
44
7632-7643
2005
Cupriavidus metallidurans
Allegri, G.; Ragazzi, E.; Costa, C.V.; Caparrotta, L.; Biasiolo, M.; Comai, S.; Bertazzo, A.
Tryptophan metabolism along the kynurenine pathway in diet-induced and genetic hypercholesterolemic rabbits
Clin. Chim. Acta
350
41-49
2004
Oryctolagus cuniculus
Comai, S.; Costa, C.V.; Ragazzi, E.; Bertazzo, A.; Allegri, G.
The effect of age on the enzyme activities of tryptophan metabolism along the kynurenine pathway in rats
Clin. Chim. Acta
360
67-80
2005
BRENDA: Rattus norvegicus
Textmining: Rattus
Yates Jennifer , Y.J.; Heyes Melvyn , H.M.; Blight Andrew , B.A.
4-chloro-3-hydroxyanthranilate reduces local quinolinic acid synthesis, improves functional recovery, and preserves white matter after spinal cord injury
J. Neurotrauma
23
866-881
2006
Cavia porcellus, Cavia porcellus Hartley
Ragazzi, E.; Costa, C.V.; Comai, S.; Bertazzo, A.; Caparrotta, L.; Allegri, G.
Cloricromene effect on the enzyme activities of the tryptophan-nicotinic acid pathway in diabetic/hyperlipidemic rabbits
Life Sci.
78
785-794
2006
Oryctolagus cuniculus, Metazoa
Maharaj, H.; Maharaj, D.S.; Daya, S.
Acetylsalicylic acid and acetaminophen protect against oxidative neurotoxicity
Metab. Brain Dis.
21
189-199
2006
BRENDA: Rattus norvegicus, Rattus norvegicus Wistar
Textmining: Rattus, Hippocampus
Li, X.; Guo, M.; Fan, J.; Tang, W.; Wang, D.; Ge, H.; Rong, H.; Teng, M.; Niu, L.; Liu, Q.; Hao, Q.
Crystal structure of 3-hydroxyanthranilic acid 3,4-dioxygenase from Saccharomyces cerevisiae: a special subgroup of the type III extradiol dioxygenases
Protein Sci.
15
761-773
2006
Saccharomyces cerevisiae
Dilovic, I.; Gliubich, F.; Malpeli, G.; Zanotti, G.; Matkovic-Calogovic, D.
Crystal structure of bovine 3-hydroxyanthranilate 3,4-dioxygenase
Biopolymers
91
1189-1195
2009
BRENDA: Bos taurus (Q0VCA8), Bos taurus
Textmining: Bacteria, Saccharomyces cerevisiae
Chakraborty, B.; Paine, T.
Aromatic ring cleavage of 2-amino-4-tert-butylphenol by a nonheme iron(II) complex: functional model of 2-aminophenol dioxygenases
Angew. Chem. Int. Ed. Engl.
52
920-924
2013
Pseudomonas oleovorans
Pidugu, L.S.; Neu, H.; Wong, T.L.; Pozharski, E.; Molloy, J.L.; Michel, S.L.; Toth, E.A.
Crystal structures of human 3-hydroxyanthranilate 3,4-dioxygenase with native and non-native metals bound in the active site
Acta Crystallogr. Sect. D
73
340-348
2017
Homo sapiens (P46952), Homo sapiens
Brkic, H.; Kovacevic, B.; Tomic, S.
Human 3-hydroxyanthranilate 3,4-dioxygenase dynamics and reaction, a multilevel computational study
Mol. Biosyst.
11
898-907
2015
Homo sapiens (P46952), Homo sapiens
Yang, Y.; Liu, F.; Liu, A.
Adapting to oxygen 3-hydroxyanthrinilate 3,4-dioxygenase employs loop dynamics to accommodate two substrates with disparate polarities
J. Biol. Chem.
293
10415-10424
2018
Cupriavidus metallidurans (Q1LCS4), Cupriavidus metallidurans ATCC 43123 (Q1LCS4)
Wang, Y.; Liu, K.F.; Yang, Y.; Davis, I.; Liu, A.
Observing 3-hydroxyanthranilate-3,4-dioxygenase in action through a crystalline lens
Proc. Natl. Acad. Sci. USA
117
19720-19730
2020
Cupriavidus metallidurans (Q1LCS4), Cupriavidus metallidurans ATCC 43123 (Q1LCS4)
Eastman, CL; Urbańska, EM; Chapman, AG; Schwarcz, R
Differential expression of the astrocytic enzymes 3-hydroxyanthranilic acid oxygenase, kynurenine aminotransferase and glutamine synthetase in seizure-prone and non-epileptic mice.
Epilepsy Res
18
185-94
1994
Mus sp., Mus musculus, Hippocampus
Nakano, K; Asai, H; Kitoh, J
Abnormally high activity of 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice.
Brain Res
572
1-4
1992
Mus sp., Metazoa
Walsh, JL; Todd, WP; Carpenter, BK; Schwarcz, R
4-Halo-3-hydroxyanthranilates are potent inhibitors of 3-hydroxyanthranilate oxygenase in the rat brain in vitro and in vivo.
Adv Exp Med Biol
294
579-82
1991
Rattus
Todd, WP; Carpenter, BK; Schwarcz, R
Preparation of 4-halo-3-hydroxyanthranilates and demonstration of their inhibition of 3-hydroxyanthranilate oxygenase activity in rat and human brain tissue.
Prep Biochem
19
155-65
1989
Homo sapiens, Rattus
Köhler, C; Eriksson, LG; Okuno, E; Schwarcz, R
Localization of quinolinic acid metabolizing enzymes in the rat brain. Immunohistochemical studies using antibodies to 3-hydroxyanthranilic acid oxygenase and quinolinic acid phosphoribosyltransferase.
Neuroscience
27
49-76
1988
Rattus, Oryctolagus cuniculus, Hippocampus, Areas
Köhler, C; Eriksson, LG; Flood, PR; Hardie, JA; Okuno, E; Schwarcz, R
Quinolinic acid metabolism in the rat brain. Immunohistochemical identification of 3-hydroxyanthranilic acid oxygenase and quinolinic acid phosphoribosyltransferase in the hippocampal region.
J Neurosci
8
975-87
1988
Rattus, Hippocampus
Lingens, F; Heilmann, HD
[Demonstration of 3-hydroxyanthranilic acid oxygenase in Saccharomyces cerevisiae]
Naturwissenschaften
54
369
1967
Saccharomyces cerevisiae
Heilmann, HD; Lingens, F
[Purification and properties of 3-hydroxyanthranilate oxygenase from Saccharomyces cerevisae]
Hoppe Seylers Z Physiol Chem
349
223-30
1968
Saccharomyces
Ogasawara, N; Gander, JE; Henderson, LM
Purification and properties of 3-hydroxyanthranilate oxygenase from beef kidney.
J Biol Chem
241
613-9
1966
Bos taurus
Chugh, K; Shanker, V; Lal, H; Saini, AS
Effect of excess leucine on tryptophan oxygenase, 3-hydroxyanthranilate oxygenase and leucine aminotransferase in livers of young rats.
Ann Nutr Metab
26
296-300
1982
Rattus
Shanker, V; Chugh, K; Lal, H; Saini, AS
Effect of dietary restriction with and without excess leucine on hepatic tryptophan oxygenase, 3-hydroxyanthranilate oxygenase and leucine aminotransferase in rats.
Ann Nutr Metab
26
227-31
1982
Rattus, Metazoa
Nakagawa, Y; Asai, H; Kitoh, J; Mori, H; Nakano, K
Increase in the level of mRNA for 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice.
Biosci Biotechnol Biochem
59
2191-2
1995
Mus sp.
Nakagawa, Y; Asai, H; Miura, T; Kitoh, J; Mori, H; Nakano, K
Increased expression of 3-hydroxyanthranilate 3,4-dioxygenase gene in brain of epilepsy-prone El mice.
Brain Res Mol Brain Res
58
132-7
1998
Mus sp., Homo sapiens, Mus musculus, animal
Ceresoli, G; Fuller, MS; Schwarcz, R
Excitotoxic lesions of the rat striatum: different responses of kynurenine pathway enzymes during ontogeny.
Brain Res Dev Brain Res
92
61-9
1996
Rattus, Metazoa
Bertazzo, A; Ragazzi, E; Biasiolo, M; Costa, CV; Allegri, G
Enzyme activities involved in tryptophan metabolism along the kynurenine pathway in rabbits.
Biochim Biophys Acta
1527
167-75
2001
Oryctolagus cuniculus
Ragazzi, E; Costa, CV; Caparrotta, L; Biasiolo, M; Bertazzo, A; Allegri, G
Enzyme activities along the tryptophan-nicotinic acid pathway in alloxan diabetic rabbits.
Biochim Biophys Acta
1571
9-17
2002
Oryctolagus cuniculus, animal
Allegri, G; Ragazzi, E; Costa, CV; Caparrotta, L; Biasiolo, M; Vanin, S
The kynurenine pathway enzymes in healthy and hyperlipidemic rabbits.
Adv Exp Med Biol
527
381-6
2003
Oryctolagus cuniculus
Allegri, G; Zaccarin, D; Ragazzi, E; Froldi, G; Bertazzo, A; Costa, CV
Metabolism of tryptophan along the kynurenine pathway in alloxan diabetic rabbits.
Adv Exp Med Biol
527
387-93
2003
Oryctolagus cuniculus
Allegri, G; Ragazzi, E; Bertazzo, A; Costa, CV; Rocchi, R
Tryptophan metabolism along the kynurenine pathway in rats.
Adv Exp Med Biol
527
481-96
2003
Rattus
Allegri, G; Ragazzi, E; Bertazzo, A; Costa, CV
Enzyme activities along the kynurenine pathway in mice.
Adv Exp Med Biol
527
497-510
2003
Mus sp., Mus musculus, animal
Eastman, CL; Urbańska, E; Löve, A; Kristensson, K; Schwarcz, R
Increased brain quinolinic acid production in mice infected with a hamster neurotropic measles virus.
Exp Neurol
125
119-24
1994
Hippocampus, Mus sp., Measles morbillivirus, Metazoa
Bender, DA; Totoe, L
Inhibition of tryptophan metabolism by oestrogens in the rat: a factor in the aetiology of pellagra.
Br J Nutr
51
219-24
1984
Rattus
Heyes, MP; Chen, CY; Major, EO; Saito, K
Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types.
Biochem J
326 ( Pt 2)
351-6
1997
Homo sapiens
Koo, YS; Kim, H; Park, JH; Kim, MJ; Shin, YI; Choi, BT; Lee, SY; Shin, HK
Indoleamine 2,3-Dioxygenase-Dependent Neurotoxic Kynurenine Metabolism Contributes to Poststroke Depression Induced in Mice by Ischemic Stroke along with Spatial Restraint Stress.
Oxid Med Cell Longev
2018
2413841
2018
Mus sp., Hippocampus
Seifert, J
Changes in mouse liver and chicken embryo yolk sac membrane soluble proteins due to an organophosphorous insecticide (OPI) diazinon linked to several noncholinergic OPI effects in mice and chicken embryos.
Pestic Biochem Physiol
116
74-82
2014
Mus musculus
Kish, SJ; Du, F; Parks, DA; Robitaille, Y; Ball, MJ; Schut, L; Hornykiewicz, O; Schwarcz, R
Quinolinic acid catabolism is increased in cerebellum of patients with dominantly inherited olivopontocerebellar atrophy.
Ann Neurol
29
100-4
1991
Homo sapiens
Speciale, C; Okuno, E; Schwarcz, R
Increased quinolinic acid metabolism following neuronal degeneration in the rat hippocampus.
Brain Res
436
18-24
1987
Hippocampus
Nakano, K; Takahashi, S; Mizobuchi, M; Kuroda, T; Masuda, K; Kitoh, J
High levels of quinolinic acid in brain of epilepsy-prone E1 mice.
Brain Res
619
195-8
1993
Mus sp.
Ghafoorunissa, ; Rao, BS
Effect of leucine on enzymes of the tryptophan-niacin metabolic pathway in rat liver and kidney.
Biochem J
134
425-430
1973
Rattus
O'Connor, JC; Lawson, MA; André, C; Briley, EM; Szegedi, SS; Lestage, J; Castanon, N; Herkenham, M; Dantzer, R; Kelley, KW
Induction of IDO by bacille Calmette-Guérin is responsible for development of murine depressive-like behavior.
J Immunol
182
3202-12
2009
Mycobacterium tuberculosis variant bovis BCG
Wiens, M; Schrder, HC; Korzhev, M; Wang, XH; Batel, R; Mller, WE
Inducible ASABF-type antimicrobial peptide from the sponge Suberites domuncula: microbicidal and hemolytic activity in vitro and toxic effect on molluscs in vivo.
Mar Drugs
9
1969-94
2011
Suberites domuncula, Gastropoda
Choi, JW; Aseer, KR; Chaudhari, HN; Mukherjee, R; Choi, M; Yun, JW
Gender dimorphism in regulation of plasma proteins in streptozotocin-induced diabetic rats.
Proteomics
13
2482-94
2013
Rattus
Schwarcz, R; Okuno, E; White, RJ; Bird, ED; Whetsell, WO
3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims.
Proc Natl Acad Sci U S A
85
4079-81
1988
Homo sapiens
Wang, X; Davis, I; Liu, A; Shamsi, SA
Development of a CZE-ESI-MS assay with a sulfonated capillary for profiling picolinic acid and quinolinic acid formation in multienzyme system.
Electrophoresis
34
1828-35
2013
Areas
Sathyasaikumar, KV; Stachowski, EK; Wonodi, I; Roberts, RC; Rassoulpour, A; McMahon, RP; Schwarcz, R
Impaired Kynurenine Pathway Metabolism in The Prefrontal Cortex of Individuals With Schizophrenia.
Schizophr Bull
2010
Homo sapiens
Boyadjiev, N
Increase of aerobic capacity by submaximal training and high-fat diets.
Folia Med (Plovdiv)
38
49-59
1996
Rattus
Luthman, J; Radesäter, AC; Oberg, C
Effects of the 3-hydroxyanthranilic acid analogue NCR-631 on anoxia-, IL-1 beta- and LPS-induced hippocampal pyramidal cell loss in vitro.
Amino Acids
14
263-9
1998
Rattus, Hippocampus
Müller, AC; Dairam, A; Limson, JL; Daya, S
Mechanisms by which acyclovir reduces the oxidative neurotoxicity and biosynthesis of quinolinic acid.
Life Sci
80
918-25
2007
Mus sp., Rattus
Vallerini, GP; Amori, L; Beato, C; Tararina, M; Wang, XD; Schwarcz, R; Costantino, G
2-Aminonicotinic acid 1-oxides are chemically stable inhibitors of quinolinic acid synthesis in the mammalian brain: a step toward new antiexcitotoxic agents.
J Med Chem
56
9482-95
2013
Rattus
McGonigle, TA; Keane, KN; Ghaly, S; Carter, KW; Anderson, D; Scott, NM; Goodridge, HS; Dwyer, A; Greenland, E; Pixley, FJ; Newsholme, P; Hart, PH
UV Irradiation of Skin Enhances Glycolytic Flux and Reduces Migration Capabilities in Bone Marrow-Differentiated Dendritic Cells.
Am J Pathol
187
2046-2059
2017
Mus sp.
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