Literature summary for 1.13.11.6 extracted from

Cesura, A.M.; Alberati-Giani, D.; Buchli, R.; Broger, C.; Kohler, C.; Vilbois, F.; Lahm, H.W.; Heitz, M.P.; Malherbe, P.
Molecular characterization of kynurenine pathway enzymes: 3-Hydroxyanthranilic-acid dioxygenase and kynurenine aminotransferase (1996), Adv. Exp. Med. Biol., 398, 477-483.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in human embryonic kidney HEK-293	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
4-Bromo-3-hydroxyanthranilic acid	-	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.002	-	3-hydroxyanthranilic acid	-	Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
32590	-	ion spray MS, recombinant enzyme	Rattus norvegicus
32630	-	ion spray MS	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3-hydroxyanthranilate + O2	-	Rattus norvegicus	2-amino-3-carboxymuconate semialdehyde	reacts spontaneously to quinolinic acid	?

Subunits

Subunits	Comment	Organism
monomer	1* 32589 or 32627, ion spray MS	Rattus norvegicus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
additional information	-	pI: 5.2	Rattus norvegicus

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Release 2023.1 (January 2023)