Information on EC 1.11.2.2 - myeloperoxidase

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The expected taxonomic range for this enzyme is: Eukaryota

EC NUMBER
COMMENTARY
1.11.2.2
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RECOMMENDED NAME
GeneOntology No.
myeloperoxidase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
Cl- + H2O2 + H+ = HClO + H2O
show the reaction diagram
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SYSTEMATIC NAME
IUBMB Comments
chloride:hydrogen-peroxide oxidoreductase (hypochlorite-forming)
Contains calcium and covalently bound heme (proximal ligand histidine). It is present in phagosomes of neutrophils and monocytes, where the hypochlorite produced is strongly bactericidal. It differs from EC 1.11.1.10 chloride peroxidase in its preference for formation of hypochlorite over the chlorination of organic substrates under physiological conditions (pH 5-8). Hypochlorite in turn forms a number of antimicrobial products (Cl2, chloramines, hydroxyl radical, singlet oxygen). MPO also oxidizes bromide, iodide and thiocyanate. In the absence of halides, it oxidizes phenols and has a moderate peroxygenase activity toward styrene.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
donor, hydrogen peroxide oxidoreductase
P05164
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donor, hydrogen peroxideoxidoreductase
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donor: H202 oxidoreductase
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donor: H202 oxidoreductase
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donor: H2O2 oxidoreductase
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donor:H2O2 oxidoreductase
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donor:H2O2 oxidoreductase
P05164
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donor:hydrogen peroxide oxidoreductase
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donor:hydrogen-peroxide oxidoreductase
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EC 1.11.1.7
P05164
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hemi-MPO
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reductive alkylation converts the normal dimeric enzyme into two protomers, hemi-myeloperoxidase
hemi-myeloperoxidase
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reductive alkylation converts the normal dimeric enzyme into two protomers, hemi-myeloperoxidase
LPO
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MPO
P05164
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MPO
P05164
isoform C
myeloperoxidase
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peroxinectin
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properoxinectin
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recombinant human MPO
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rhMPO
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tissue myeloperoxidase
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ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
Armoracia sp.
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-
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Manually annotated by BRENDA team
horse, myeloperoxidase
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Manually annotated by BRENDA team
myeloperoxidase
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Manually annotated by BRENDA team
myeloperoxidase and eosinophil peroxidase
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Manually annotated by BRENDA team
myeloperoxidase has six isozymes
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Manually annotated by BRENDA team
japanese radish, 18 isozymes, here JRPa and JRPc
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Manually annotated by BRENDA team