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Literature summary for 1.11.2.2 extracted from

  • Kettle, A.J.; Gedye, C.A.; Hampton, M.B.; Winterbourn, C.C.
    Inhibition of myeloperoxidase by benzoic acid hydrazides (1995), Biochem. J., 308, 559-563.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
3-methoxybenzoic acid hydrazide
-
Homo sapiens
3-nitrobenzoic acid hydrazide
-
Homo sapiens
4-aminobenzoic acid hydrazide most potent inhibitor of peroxidation, it irreversibly inhibits HOCl production by the purified myeloperoxidase. With neutrophils stimulated with opsonized zymosan or phorbol myristate acetate, 4-aminobenzoic acid hydrazide inhibits HOCI production by up to 90% Homo sapiens
4-chlorobenzoic acid hydrazide
-
Homo sapiens
4-hydroxybenzoic acid hydrazide
-
Homo sapiens
4-methoxybenzoic acid hydrazide
-
Homo sapiens
benzoic hydrazide
-
Homo sapiens
Salicylhydroxamic acid salicylhydroxamic acid is a much poorer inhibitor of HOCI production with neutrophils stimulated with opsonized zymosan (0.2 mM is required for complete inhibition) Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Cl- + H2O2 + H+ Homo sapiens
-
HClO + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Cl- + H2O2 + H+
-
Homo sapiens HClO + H2O
-
?
tetramethylbenzidine + H2O2 + H+
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
donor: H2O2 oxidoreductase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0003
-
at 37°C, in 50 mM acetate buffer, pH 5.4 Homo sapiens 4-aminobenzoic acid hydrazide
0.032
-
at 37°C, in 50 mM acetate buffer, pH 5.4 Homo sapiens Salicylhydroxamic acid