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Literature summary for 1.11.2.2 extracted from

  • Meotti, F.C.; Jameson, G.N.; Turner, R.; Harwood, D.T.; Stockwell, S.; Rees, M.D.; Thomas, S.R.; Kettle, A.J.
    Urate as a physiological substrate for myeloperoxidase: implications for hyperuricemia and inflammation (2010), J. Biol. Chem., 186, 12901-12911.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.11.2.2

Inhibitors

Inhibitors Comment Organism Structure
Urate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ascorbate + H2O2 Homo sapiens
-
 ?
-
 ?
Cl- + H2O2 Homo sapiens
-
 HClO + H2O
-
 ?
tyrosine + H2O2 Homo sapiens
-
 ?
-
 ?
urate + H2O2 Homo sapiens
-
 5-hydroxyisourate + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-
leukocyte
-
 Homo sapiens
-
neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ascorbate + H2O2
-
 Homo sapiens ?
-
 ?
Cl- + H2O2
-
 Homo sapiens HClO + H2O
-
 ?
tyrosine + H2O2
-
 Homo sapiens ?
-
 ?
urate + H2O2
-
 Homo sapiens 5-hydroxyisourate + H2O
-
 ?

Synonyms

Synonyms Comment Organism
MPO
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0093
-
 pH and temperature not specified in the publication Homo sapiens Urate

Expression

Organism Comment Expression
Homo sapiens urate enhances MPO-dependent consumption of nitric oxide up