Information on EC 1.11.1.6 - catalase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

EC NUMBER
COMMENTARY hide
1.11.1.6
-
RECOMMENDED NAME
GeneOntology No.
catalase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 H2O2 = O2 + 2 H2O
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of antibiotics
-
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Biosynthesis of secondary metabolites
-
-
ethanol degradation IV
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-
Glyoxylate and dicarboxylate metabolism
-
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methanol oxidation to formaldehyde IV
-
-
non-pathway related
-
-
reactive oxygen species degradation
-
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superoxide radicals degradation
-
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Tryptophan metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
hydrogen-peroxide:hydrogen-peroxide oxidoreductase
A hemoprotein. A manganese protein containing MnIII in the resting state, which also belongs here, is often called pseudocatalase. The enzymes from some organisms, such as Penicillium simplicissimum, can also act as a peroxidase (EC 1.11.1.7) for which several organic substances, especially ethanol, can act as a hydrogen donor. Enzymes that exhibit both catalase and peroxidase activity belong under EC 1.11.1.21, catalase-peroxidase.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-05-2
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
enzyme expression is induced under phosphate-limiting growth conditions
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
isozyme Cat1.4
-
-
Manually annotated by BRENDA team
strain OF4
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-
Manually annotated by BRENDA team
strain OF4
-
-
Manually annotated by BRENDA team
strain ATCC 14581
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-
Manually annotated by BRENDA team
strain 13
-
-
Manually annotated by BRENDA team
strain N2a
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Beta vulgaris var. cicla
-
-
-
Manually annotated by BRENDA team
originally isolated from honeybee intestine, gene katA
UniProt
Manually annotated by BRENDA team
originally isolated from honeybee intestine, gene katA
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Brassica oleracea gongylodes, kohlrabi
-
-
Manually annotated by BRENDA team
three enzyme isoforms
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
bifunctional catalase-peroxidase KatG
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Capra capra
goat
-
-
Manually annotated by BRENDA team
microfungus isolated from soil collected in arctic tundra
-
-
Manually annotated by BRENDA team
Colwellia sp.
strain MH2
-
-
Manually annotated by BRENDA team
Colwellia sp. MH2
strain MH2
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-
Manually annotated by BRENDA team
Pacific oyster
-
-
Manually annotated by BRENDA team
Cucurbita sp.
pumpkin
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-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
gene katA
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-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
strain K12
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Manually annotated by BRENDA team
LLR02022, contains a catalase and a bifunctional catalase-peroxidase
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-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
bifunctional catalase-peroxidase KatG
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-
Manually annotated by BRENDA team
strain 26695, gene katA, enzyme KatA
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-
Manually annotated by BRENDA team
Helicobacter pylori Taiwanese TW-34
strain Taiwanese TW-34, gene katA, enzyme KatA
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-
Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
strain IFO 14940
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-
Manually annotated by BRENDA team
strain IFO 14940
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-
Manually annotated by BRENDA team
Kloeckera sp.
strain 2201
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Manually annotated by BRENDA team
Kloeckera sp. 2201
strain 2201
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-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
ATCC 51441, ATCC 51442, and ATCC 51440
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Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
microfungus isolated from soil collected in arctic tundra
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Manually annotated by BRENDA team
microfungus isolated from soil collected in arctic tundra, 2 strains
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-
Manually annotated by BRENDA team
Mus musculus BALB/c
Balb/c mice
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-
Manually annotated by BRENDA team
strain JC1, DSM 3803
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Manually annotated by BRENDA team
strain JC1, DSM 3803
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Manually annotated by BRENDA team
microfungus isolated from soil collected in arctic tundra, 2 strains
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-
Manually annotated by BRENDA team
no activity in Amphiprora kufferathii
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Manually annotated by BRENDA team
subspecies Oceanobacillus oncorhynchi incaldaniensis, strain 20AG
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-
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
Paracoccidioides brasiliensis Pb01 ATCC-MYA-826
Pb01, ATCC-MYA-826
SwissProt
Manually annotated by BRENDA team
cytochrome c oxidase with catalase activity; gene ctaG
UniProt
Manually annotated by BRENDA team
cytochrome c oxidase with catalase activity; gene ctaG
UniProt
Manually annotated by BRENDA team
microfungus isolated from soil collected in arctic tundra
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-
Manually annotated by BRENDA team
strain 1, microfungus isolated from soil collected in arctic tundra
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Manually annotated by BRENDA team
strain 1, microfungus isolated from soil collected in arctic tundra
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Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
-
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-
Manually annotated by BRENDA team
Pibocella sp.
strain MH3
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Manually annotated by BRENDA team
Pibocella sp. MH3
strain MH3
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
microfungus isolated from soil collected in arctic tundra
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Manually annotated by BRENDA team
KatA
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Manually annotated by BRENDA team
strain mt-2. Expression of the katB gene encoding isoform catalase B is specific to the stationary phase and entirely dependent on the rpoS gene, while the katA gene expressed during log phase partially requires rpoS
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Manually annotated by BRENDA team
pv. syringae 61
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Manually annotated by BRENDA team
isolated from the drain pool of a plant that uses H2O2 as a bleaching agent
UniProt
Manually annotated by BRENDA team
isolated from the drain pool of a plant that uses H2O2 as a bleaching agent
UniProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain VA1, hyperthermophilic archaeon, facultatively anaerobic, gene katPc
SwissProt
Manually annotated by BRENDA team
strain VA1, hyperthermophilic archaeon, facultatively anaerobic, gene katPc
SwissProt
Manually annotated by BRENDA team
Wistar
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Manually annotated by BRENDA team
strain S1
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Manually annotated by BRENDA team
OCh 323
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Manually annotated by BRENDA team
Roseibacterium elongatum OCh 323
OCh 323
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Manually annotated by BRENDA team
strain EL-88
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Manually annotated by BRENDA team
strain EL-88
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Manually annotated by BRENDA team
Sclerotium sp.
isolated from soil collected in arctic tundra
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Manually annotated by BRENDA team
gene catpo
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Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
isoform KatA, enzyme expression is induced under phosphate-limiting growth conditions resulting in dramatic increase in H2O2 resistance of wild-type cells, but not of promoter phoB mutant cells
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain WZ2
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Manually annotated by BRENDA team
strain WZ2
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Manually annotated by BRENDA team
Sulfitobacter sp.
strain MH1
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Manually annotated by BRENDA team
Sulfitobacter sp. MH1
strain MH1
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Manually annotated by BRENDA team
microfungus isolated from soil collected in arctic tundra, 2 strains
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Manually annotated by BRENDA team
strain F-648
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
2 enzymes TvC-I and TvC-II
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain HY34
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Manually annotated by BRENDA team
strain HY34
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-H-pyrrol-2-carbohydrazide
?
show the reaction diagram
-
analysis of association and dissociation rate constants
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-
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2 H2O2
O2 + 2 H2O
show the reaction diagram
2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) + H2O2
? + H2O
show the reaction diagram
2,6-dimethoxyphenol + H2O2
? + H2O
show the reaction diagram
3,3'-diaminobenzidine + H2O2
? + H2O
show the reaction diagram
3,3'-dimethoxybenzidine + H2O2
? + H2O
show the reaction diagram
4-aminoantipyrine + H2O2
? + H2O
show the reaction diagram
-
-
-
?
ascorbate + H2O2
? + H2O
show the reaction diagram
benzoic hydrazide
?
show the reaction diagram
-
analysis of association and dissociation rate constants
-
-
-
beta-(3,4-dihydroxyphenyl)-L-alanine + H2O2
? + H2O
show the reaction diagram
catechol + H2O2
? + H2O
show the reaction diagram
-
-
-
?
ethanol + H2O2
acetaldehyde + ?
show the reaction diagram
ethyl hydrogen peroxide + ethanol
acetaldehyde + ?
show the reaction diagram
ethyl hydrogen peroxide + methanol
acetaldehyde + ?
show the reaction diagram
ethyl hydrogen peroxide + nitrite
acetaldehyde + ?
show the reaction diagram
formic acid + H2O2
?
show the reaction diagram
-
-
-
?
furoic hydrazide
?
show the reaction diagram
-
analysis of association and dissociation rate constants
-
-
-
H2O
O2 + H2O
show the reaction diagram
-
-
-
-
?
H2O2
O2 + H2O
show the reaction diagram
H2O2 + 2-aminophenol
?
show the reaction diagram
H2O2 + 3-chlorophenol
?
show the reaction diagram
H2O2 + 4-chlorophenol
?
show the reaction diagram
H2O2 + 4-nitrophenol
?
show the reaction diagram
-
-
-
-
?
H2O2 + dimethylaniline
?
show the reaction diagram
-
low activity
-
-
?
H2O2 + methanol
formaldehyde + H2O
show the reaction diagram
H2O2 + o-dianisidine
? + H2O
show the reaction diagram
H2O2 + phenol
?
show the reaction diagram
-
-
-
-
?
H2O2 + propyl gallate
?
show the reaction diagram
-
best peroxidase substrate
-
-
?
H2O2 + pyrocatechol
?
show the reaction diagram
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-
-
-
?
isonicotinic hydrazide
?
show the reaction diagram
-
antituberculosis drug, bactericidal function neeeds activation by bifunctional catalase-peroxidase KatG to produce an acyl-NAD adduct. Substrate binds with high affinity to a small portion of ferric enzyme in a six-coordinate heme iron form
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-
?
methanol + H2O2
formaldehyde + ?
show the reaction diagram
methyl hydrogen peroxide
formaldehyde + ?
show the reaction diagram
-
-
-
?
NADH + H2O2
NAD+ + H2O
show the reaction diagram
-
-
-
?
NADPH + H2O2
NADP+ + H2O
show the reaction diagram
-
-
-
?
nicotinic hydrazide
?
show the reaction diagram
-
analysis of association and dissociation rate constants
-
-
-
o-dianisidine + H2O2
? + H2O
show the reaction diagram
o-methoxyphenol + H2O2
? + H2O
show the reaction diagram
picolinic hydrazide
?
show the reaction diagram
-
analysis of association and dissociation rate constants
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-
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pyrogallol + H2O2
? + H2O
show the reaction diagram
reduced cytochrome c + H2O2
oxidized cytochrome c + H2O
show the reaction diagram
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-
?
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2 H2O2
O2 + 2 H2O
show the reaction diagram
H2O2
O2 + H2O
show the reaction diagram
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
heme c
-
8 molecules per teramer
additional information
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Cu2+
-
less than 0.2 g-atom cupper per mol enzyme
Fe3+
-
the active site of the enzyme contains Fe3+
K+
-
stimulatory effect at 2 mM
Mg2+
-
stimulatory effect at 2 mM
Na+
-
stimulatory effect at 2 mM
NaCl
-
there is a stimulation of catalase by addition of NaCl 10 mM (176%)
additional information
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(+)-catechin
-
-
(-)-epigallocatechin
-
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1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one
-
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid)
-
inhibition is pH-dependent. Lowest concentration where inhibition is observed is 1.2 mM at pH 4.5, 0.6 mM at pH 4.3, 0.3 mM at pH 4.0
2-mercaptoethanol
3-Amino-1,2,4-triazole
3-amino-1H-1,2,4-triazole
4-aminoantipyrine
-
inhibition of catalase activity
5,5-dithiobis(2-nitrobenzoic acid)
Capra capra
-
complete inhibition at 0.4 mM
6-Chloropurine
-
-
acetic acid
-
in vitro inhibitor
apigenin
-
-
ascorbate
-
in vitro inhibitor
Astragalin
-
-
Ba2+
-
partial inhibition at 2 mM
beta-mercaptoethanol
-
-
BO3-
Capra capra
-
weak inhibition at 1 mM
-
CaCl2
-
irreversible loss of activity at 2 M
CAS 1609
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-
catechol
-
-
Co2+
-
partial inhibition at 2 mM
cyanide
dinitrosyl iron complex
-
decrease in enzyme activity without changing the mechanism. The inhibition efficiency is elevated by two orders of magnitude and also increases with decrease in pH in the presence of 150 mM chloride or 150 mM bromide or 0.050 mM thiocyanate. In presence of oxyhemoglobin plus o-phenanthroline, the inhibitory effect is sharply attenuated
Dithionite
dithiothreitol
eicosapentaenoic acid
-
the incubation of Jurkat cells with 0.1 mM eicosapentaenoic acid causes a significant decrease of catalase activity but not of protein or mRNA content
Endogenous inhibitor
-
purified on catalase-Sepharose from bovine, different inhibition sensitivities for three isoforms
-
Epicatechin gallate
-
-
epigallocatechin gallate
-
-
ethane-1,2-diol
-
activity at 30-60C in presence of ethanol-1,2-diol, overview
ethanol
-
in vitro inhibitor
formaldehyde
Capra capra
-
non-competitive inhibition
formic acid
-
in vitro inhibitor
galangin
-
-
gallic acid
-
-
gamma-linolenic acid
-
the incubation of Jurkat cells with 0.05 mM gamma-linolenic acid causes a significant decrease of catalase activity but not of protein or mRNA content
Glutaraldehyde
glycerol trinitrate
-
-
histidine
-
10 mM histidine reduces activity by 19%
hydroxyl radicals
inactivation of isoform Cat-1
hydroxylamine
Hydroxylamine hydrochloride
-
strong inhibition
indole acetic acid
Capra capra
-
non-competitive inhibition
inositol phosphoglycan-like compound from Bos taurus thyroid gland
-
produced by the hydrolysis of the membrane-bound glycosyl phosphoinositides, noncompetitive inhibition. 50% residual activity, the site of action is not the prosthetic group
-
inositol phosphoglycan-like compound from Escherichia coli
-
produced by the hydrolysis of the membrane-bound glycosyl phosphoinositides, noncompetitive inhibition. 50% residual activity, the site of action is not the prosthetic group
-
iodoacetamide
isosorbide dinitrate
-
-
kaempferol
-
-
KNO2
-
37% inhibition at 1 mM
KNO3
-
14% inhibition at 1 mM
L-aspartic acid
L-cysteine
Capra capra
-
35% inhibition at 3.3 mM
L-Glutamic acid
Beta vulgaris var. cicla
-
84% inhibition at 30 mM
L-lactic acid
Capra capra
-
63% inhibition at 25 mM
L-Malic acid
Capra capra
-
50% inhibition at 6 mM
L-tryptophan
Capra capra
-
80% inhibition at 1.6 mM
L-tyrosine
Capra capra
-
80% inhibition at 5 mM
linoleic acid
-
the incubation of Jurkat cells with 0.1 mM linoleic acid causes a significant decrease of catalase activity but not of protein or mRNA content
luteolin
-
-
Maleic acid
Capra capra
-
51% inhibition at 0.8 mM
methanol
-
in vitro inhibitor
MgCl2
-
irreversible loss of activity at 2 M
myricetin
-
-
N-bromosuccinimide
Capra capra
-
complete inhibition at 3.34 mM
N-ethylmaleimide
Capra capra
-
complete inhibition at 18.3 mM
nitrite
NO
generated from 1-(N,N-diethylamino)diazen-1-ium-1,2-diolate, competitive inhibitor, nitrosylated catalase is kinetically labile, NO tends to dissociate rapidly from the active site, binding structure, overview. Kinetic analysis of dissociation of NO from the enzyme-inhibitor complex
oleic acid
-
the incubation of Jurkat cells with 0.2 mM oleic acid causes a significant decrease of catalase activity but not of protein or mRNA content
oxalic acid
Capra capra
-
51% inhibition at 4 mM
p-chloromercuribenzoate
Capra capra
-
complete inhibition at 0.33 mM, summation effect with 2-mercaptoethanol
palmitic acid
-
the incubation of Jurkat cells with 0.2 mM palmitic acid causes a significant decrease of catalase activity but not of protein or mRNA content
pentaerythritol tetranitrate
-
-
Phenol
-
inhibition of catalase activity
pyocyanin
-
may decrease cellular catalase activity via both transcriptional regulation and direct inactivation of the enzyme
pyrogallol
-
-
Pyruvic acid
Capra capra
-
16% inhibition at 5 mM
quercetin
-
-
rutin
-
-
S-nitrosocysteine
-
-
S-nitrosoglutathione
SDS
Beta vulgaris var. cicla
-
55% inhibition at 0.01%
SO3-
Capra capra
-
weak inhibition at 4 mM
Sodium azide
Sodium cyanide
Sodium dithionite
-
inhibitory
sodium nitroprusside
-
-
stearic acid
-
the incubation of Jurkat cells with 0.2 mM stearic acid causes a significant decrease of catalase activity but not of protein or mRNA content
Urea
Beta vulgaris var. cicla
-
50% inhibition at 4 M in 3.5 min
additional information