6.5.1.B1: 2'-5' RNA ligase (NTP-independent)

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For detailed information about 2'-5' RNA ligase (NTP-independent), go to the full flat file.

Reaction

a 3'-half-tRNA molecule with a 5'-OH end

a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end

a mature tRNA molecule containing a 2'-5'-phosphodiester bond

ECTree

6 Ligases

6.5 Forming phosphoric-ester bonds

6.5.1 Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)

6.5.1.B1 2'-5' RNA ligase (NTP-independent)

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1	Temperature Optimum [°C]

Natural Substrates Products

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Natural Substrates Products on EC 6.5.1.B1 - 2'-5' RNA ligase (NTP-independent)

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additional information

Escherichia coli

P37025

the apparent requirement of Escherichia coli 2'-5' ligase for nucleoside modifications and the preference shown by this enzyme for a subset of Saccharomyces cerevisiae tRNA splicing substrates suggest that the Escherichia coli ligase is likely to act upon a tRNA or tRNA-like molecule in vivo. The tight binding of the RNA ligase to immobilized prokaryotic and eukaryotic tRNA provides evidence that the ligase recognizes a tRNA or tRNA-like substrate in vivo

722602