6.5.1.6: DNA ligase (ATP or NAD+)

This is an abbreviated version!
For detailed information about DNA ligase (ATP or NAD+), go to the full flat file.

Reaction

Synonyms

Tfu DNA ligase

ECTree

     6 Ligases

         6.5 Forming phosphoric-ester bonds

             6.5.1 Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)

                6.5.1.6 DNA ligase (ATP or NAD+)

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Results	in table
107	AA Sequence
2	Cloned(Commentary)
4	Inhibitors
2	KM Value [mM]
5	Metals/Ions
1	Molecular Weight [Da]
2	Organism
1	PDB ID
3	pH Optimum
2	pH Range
2	Purification (Commentary)
11	Reaction
2	Reference
8	Substrates and Products (Substrate)
1	Subunits
1	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
2	Temperature Range [°C]
2	Temperature Stability [°C]

Substrates Products

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Substrates Products on EC 6.5.1.6 - DNA ligase (ATP or NAD+)

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

ADP + (deoxyribonucleotide)n + (deoxyribonucleotide)m

AMP + phosphate + (deoxyribonucleotide)n+m

Thermococcus onnurineus

Q2Q452

about 10% of the activity compared to ATP

672745

-

-

?

ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m

AMP + diphosphate + (deoxyribonucleotide)n+m

2 entries

GTP + (deoxyribonucleotide)n + (deoxyribonucleotide)m

GMP + diphosphate + (deoxyribonucleotide)n+m

Thermococcus onnurineus

Q2Q452

about 20% of the activity compared to ATP

672745

-

-

?

NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m

AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m

2 entries

TTP + (deoxyribonucleotide)n + (deoxyribonucleotide)m

TMP + diphosphate + (deoxyribonucleotide)n+m

Thermococcus onnurineus

Q2Q452

about 20% of the activity compared to ATP

672745

-

-

?

UTP + (deoxyribonucleotide)n + (deoxyribonucleotide)m

UMP + diphosphate + (deoxyribonucleotide)n+m

Thermococcus onnurineus

Q2Q452

about 15% of the activity compared to ATP

672745

-

-

?

ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m

AMP + diphosphate + (deoxyribonucleotide)n+m

Thermococcus fumicolans

Q9HH07

the enzyme displays nick joining and blunt-end ligation activity using either ATP or NAD+, as a cofactor

661788

-

-

?

ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m

AMP + diphosphate + (deoxyribonucleotide)n+m

Thermococcus onnurineus

Q2Q452

the enzyme displays nick joining and blunt-end ligation activity. ATP and NAD+ are comparably active

672745

-

-

?

NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m

AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m

Thermococcus fumicolans

Q9HH07

the enzyme displays nick joining and blunt-end ligation activity using either ATP or NAD+, as a cofactor

661788

-

-

?

NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m

AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m

Thermococcus onnurineus

Q2Q452

the enzyme displays nick joining and blunt-end ligation activity. ATP and NAD+ are comparably active

672745

-

-

?