6.4.1.8: acetophenone carboxylase
This is an abbreviated version!
For detailed information about acetophenone carboxylase, go to the full flat file.
Word Map on EC 6.4.1.8
-
6.4.1.8
-
aromaticum
-
aromatoleum
-
benzoylacetate
-
acetone
-
ethylbenzene
-
bicarbonate
-
denitrifying
-
s-1-phenylethanol
-
petroleum
-
bal
-
zn
-
atpase
-
ii-like
-
betaproteobacterium
-
polyproline
-
analysis
- 6.4.1.8
- aromaticum
-
aromatoleum
-
benzoylacetate
- acetone
- ethylbenzene
- bicarbonate
-
denitrifying
-
s-1-phenylethanol
-
petroleum
- bal
- zn
- atpase
-
ii-like
-
betaproteobacterium
-
polyproline
- analysis
Reaction
2 ATP
+
Synonyms
Apc1, APC2, Apc3, Apc4, Apc5, Apcalpha, Apcbeta, Apcgamma
ECTree
6.4.1.8 acetophenone carboxylaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 6.4.1.8 - acetophenone carboxylase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2 ATP + 4-acetylpyridine + HCO3- + H2O + H+
2 ADP + 2 phosphate + 2-oxo-3-(pyridin-4-yl)propanoate
2 ATP + 4-acetylpyridine + HCO3- + H2O + H+
2 ADP + 2 phosphate + 2-oxo-3-(pyridin-4-yl)propanoate
-
22% of the activity with acetophenone
-
-
?
2 ATP + 4-acetylpyridine + HCO3- + H2O + H+
2 ADP + 2 phosphate + 2-oxo-3-(pyridin-4-yl)propanoate
-
22% of the activity with acetophenone
-
-
?
2 ATP + acetophenone + HCO3- + H2O + H+
2 ADP + 2 phosphate + 3-oxo-3-phenylpropanoate
-
-
-
-
?
2 ATP + acetophenone + HCO3- + H2O + H+
2 ADP + 2 phosphate + 3-oxo-3-phenylpropanoate
-
anaerobic ethylbenzene metabolism in the betaproteobacterium Aromatoleum aromaticum is initiated by anaerobic oxidation to acetophenone via (S)-1-phenylethanol. The subsequent carboxylation of acetophenone to benzoylacetate is catalyzed by an acetophenone-induced enzyme
-
-
?
2 ATP + acetophenone + HCO3- + H2O + H+
2 ADP + 2 phosphate + 3-oxo-3-phenylpropanoate
-
the enzyme shows uncoupled ATPase activity with either bicarbonate or acetophenone in the absence of the second substrate. These observations indicate that both substrates may be phosphorylated. Purified enzyme shows no activity with GTP, CTP, UTP or ITP
-
-
?
2 ATP + acetophenone + HCO3- + H2O + H+
2 ADP + 2 phosphate + 3-oxo-3-phenylpropanoate
-
-
-
-
?
2 ATP + acetophenone + HCO3- + H2O + H+
2 ADP + 2 phosphate + 3-oxo-3-phenylpropanoate
-
anaerobic ethylbenzene metabolism in the betaproteobacterium Aromatoleum aromaticum is initiated by anaerobic oxidation to acetophenone via (S)-1-phenylethanol. The subsequent carboxylation of acetophenone to benzoylacetate is catalyzed by an acetophenone-induced enzyme
-
-
?
2 ATP + acetophenone + HCO3- + H2O + H+
2 ADP + 2 phosphate + 3-oxo-3-phenylpropanoate
-
the enzyme shows uncoupled ATPase activity with either bicarbonate or acetophenone in the absence of the second substrate. These observations indicate that both substrates may be phosphorylated. Purified enzyme shows no activity with GTP, CTP, UTP or ITP
-
-
?
2 ATP + propiophenone + HCO3- + H2O + H+
2 ADP + 2 phosphate + 4-oxo-4-phenylbutanoate
-
108% of the activity with acetophenone
-
-
?
2 ATP + propiophenone + HCO3- + H2O + H+
2 ADP + 2 phosphate + 4-oxo-4-phenylbutanoate
-
108% of the activity with acetophenone
-
-
?
additional information
?
-
-
no activity with acetone, butanone, 4-hydroxy-acetophenone or 4-amino-acetophenone
-
-
?
additional information
?
-
-
no activity with acetone, butanone, 4-hydroxy-acetophenone or 4-amino-acetophenone
-
-
?
