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6.4.1.8: acetophenone carboxylase

This is an abbreviated version!
For detailed information about acetophenone carboxylase, go to the full flat file.

Word Map on EC 6.4.1.8

Reaction

2 ATP +

acetophenone
+
HCO3-
 +
H2O
 +
H+
=
2 ADP
 + 2 phosphate +
3-oxo-3-phenylpropanoate

Synonyms

Apc1, APC2, Apc3, Apc4, Apc5, Apcalpha, Apcbeta, Apcgamma

ECTree

     6 Ligases
         6.4 Forming carbon-carbon bonds
             6.4.1 Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
                6.4.1.8 acetophenone carboxylase

Inhibitors

Inhibitors on EC 6.4.1.8 - acetophenone carboxylase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
beta,gamma-Imido-ATP
-
2 mM, complete inhibition of acetophenone carboxylase activity, non-competitive inhibition
Carbamoyl phosphate
-
2 mM: 50% inhibition of ATPase activity. 8 mM: 50% inhibition of carboxylating activity
Mg2+
-
20 mM: 50% inhibition
Mn2+
-
10 mM: 50% inhibition
Ni2+
-
1 mM: 50% inhibition of ATPase activity. 2.5 mM: 50% inhibition of carboxylation activity
Zn2+
-
the enzyme contains 1 Zn2+ ion per alphabetagammadelta core complex. In spite of the presence of Zn in the enzyme, it is strongly inhibited by Zn2+ ions. 0.2 mM ZnCl2: 50% inhibition of ATPase activity and carboxylation activity
additional information
-
acetophenone carboxylation activity in cell extracts is not sensitive to avidin, indicating that the enzyme is independent of biotin
-