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6.4.1.5: geranoyl-CoA carboxylase

This is an abbreviated version!
For detailed information about geranoyl-CoA carboxylase, go to the full flat file.

Word Map on EC 6.4.1.5

Reaction

ATP
+
geranoyl-CoA
+
HCO3-
+
H+
=
ADP
+
phosphate
+
3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA

Synonyms

AtuC, AtuC/AtuF, Carboxylase, geranoyl coenzyme A, Gcase, GCCase, Geranoyl coenzyme A carboxylase, Geranyl-CoA carboxylase

ECTree

     6 Ligases
         6.4 Forming carbon-carbon bonds
             6.4.1 Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
                6.4.1.5 geranoyl-CoA carboxylase

KM Value

KM Value on EC 6.4.1.5 - geranoyl-CoA carboxylase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.014
3-methylcrotonyl-CoA
-
pH 8.5, 37°C
0.008 - 0.01
ATP
0.064
geranoyl-CoA
-
-
0.58 - 0.6
HCO3-
additional information
additional information
-
GCCase shows sigmoidal kinetic behavior for geranoyl-CoA and bicarbonate but shows Michaelis-Menten kinetics for 3-methylcrotonyl-CoA and the cosubstrate ATP. The apparent K0.5 values of GCCase are 8.8 microM and 1.2 microM for geranoyl-CoA and bicarbonate, respectively
-