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6.4.1.5: geranoyl-CoA carboxylase

This is an abbreviated version!
For detailed information about geranoyl-CoA carboxylase, go to the full flat file.

Word Map on EC 6.4.1.5

Reaction

ATP
+
geranoyl-CoA
 +
HCO3-
 +
H+
=
ADP
 +
phosphate
 +
3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA

Synonyms

AtuC, AtuC/AtuF, Carboxylase, geranoyl coenzyme A, Gcase, GCCase, Geranoyl coenzyme A carboxylase, Geranyl-CoA carboxylase

ECTree

     6 Ligases
         6.4 Forming carbon-carbon bonds
             6.4.1 Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
                6.4.1.5 geranoyl-CoA carboxylase

Crystallization

Crystallization on EC 6.4.1.5 - geranoyl-CoA carboxylase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
structure of the hexamer of the beta-subunit, to 2.4 A resolution
structure of the 750-kDa alpha6beta6 holoenzyme and comparison with 3-methylcrotonyl-CoA carboxylase, EC 6.4.1.4. Structural differences in the active site region of both enzymes explain their distinct substrate preferences and support two distinct lineages of biotin-dependent acyl-CoA carboxylases, one carboxylating the alpha carbon of a saturated organic acid and the other carboxylating the gamma carbon of an alpha-beta unsaturated acid. A glycine residue in geranyl-CoA carboxylase is replaced by phenylalanine in 3-methylcrotonyl-CoA carboxylase, which blocks access by the larger geranyl-CoA substrate
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