6.3.5.11: cobyrinate a,c-diamide synthase

This is an abbreviated version!
For detailed information about cobyrinate a,c-diamide synthase, go to the full flat file.

Reaction

2 ATP +

Synonyms

CbiA, CobB

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor

                6.3.5.11 cobyrinate a,c-diamide synthase

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Results	in table
8744	AA Sequence
1	Application
3	Cloned(Commentary)
1	General Information
1	Inhibitors
4	kcat/KM [mM/s]
11	KM Value [mM]
5	Molecular Weight [Da]
6	Organism
5	Pathway
2	pH Optimum
8	Protein Variants
1	Purification (Commentary)
4	Reaction
6	Reference
1	Specific Activity [micromol/min/mg]
16	Substrates and Products (Substrate)
2	Subunits
3	Synonyms
1	Systematic Name
4	Turnover Number [1/s]

Reaction

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Reaction on EC 6.3.5.11 - cobyrinate a,c-diamide synthase

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

2 ATP + cobyrinate + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + cobyrinate a,c-diamide + 2 L-glutamate

2 entries

ATP + cobyrinate + L-glutamine + H2O = ADP + phosphate + cobyrinate c-monamide + L-glutamate

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ATP + cobyrinate c-monamide + L-glutamine + H2O = ADP + phosphate + cobyrinate a,c-diamide + L-glutamate

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2 ATP + cobyrinate + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + cobyrinate a,c-diamide + 2 L-glutamate

catalytic mechanism in which CbiA catalyzes the amidation of the c-carboxylate, and then the intermediate is released into solution and binds to the same catalytic site for the amidation of the a-carboxylate

Salmonella enterica subsp. enterica serovar Typhimurium

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661083

2 ATP + cobyrinate + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + cobyrinate a,c-diamide + 2 L-glutamate

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