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6.3.5.11: cobyrinate a,c-diamide synthase

This is an abbreviated version!
For detailed information about cobyrinate a,c-diamide synthase, go to the full flat file.

Reaction

2 ATP +

cobyrinate
+ 2 L-glutamine + 2 H2O =
2 ADP
+ 2 phosphate +
cobyrinate a,c-diamide
+ 2 L-glutamate

Synonyms

CbiA, CobB

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor
                6.3.5.11 cobyrinate a,c-diamide synthase

Application

Application on EC 6.3.5.11 - cobyrinate a,c-diamide synthase

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
synthesis
-
co-expression of the cobA gene from Propionibacterium freudenreichii and the cbiA, -C, -D, -E, -T, -F, -G, -H, -J, -K, -L, and -P genes from Salmonella enterica serovar typhimurium in Escherichia coli result in the production of cobyrinic acid a,c-diamide. Strains that have neither cbiP nor cbiA synthesized 1-desmethylcobyrinic acid even in the presence of cbiD, suggesting that CbiA and CbiP are necessary for CbiD activity