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6.3.5.11: cobyrinate a,c-diamide synthase

This is an abbreviated version!
For detailed information about cobyrinate a,c-diamide synthase, go to the full flat file.

Reaction

2 ATP +

cobyrinate
+ 2 L-glutamine + 2 H2O =
2 ADP
+ 2 phosphate +
cobyrinate a,c-diamide
+ 2 L-glutamate

Synonyms

CbiA, CobB

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor
                6.3.5.11 cobyrinate a,c-diamide synthase

Reference

Reference on EC 6.3.5.11 - cobyrinate a,c-diamide synthase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Debussche, L.; Thibaut, D.; Cameron, B.; Crouzet, J.; Blanche, F.
Purification and characterization of cobyrinic acid a,c-diamide synthase from Pseudomonas denitrificans
J. Bacteriol.
172
6239-6244
1990
Pseudomonas denitrificans (nom. rej.)
Manually annotated by BRENDA team
Galperin, M.Y.; Grishin, N.V.
The synthetase domains of cobalamin biosynthesis amidotransferases cobB and cobQ belong to a new family of ATP-dependent amidoligases, related to dethiobiotin synthetase
Proteins
41
238-247
2000
Pseudomonas denitrificans (nom. rej.) (P21632), Salmonella enterica subsp. enterica serovar Typhimurium (P29946)
Manually annotated by BRENDA team
Fresquet, V.; Williams, L.; Raushel, F.M.
Mechanism of cobyrinic acid a,c-diamide synthetase from Salmonella typhimurium LT2
Biochemistry
43
10619-10627
2004
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Raux, E.; Lanois, A.; Rambach, A.; Warren, M.J.; Thermes, C.
Cobalamin (vitamin B12) biosynthesis: functional characterization of the Bacillus megaterium cbi genes required to convert uroporphyrinogen III into cobyrinic acid a,c-diamide
Biochem. J.
335 (Pt 1)
167-173
1998
Priestia megaterium
Manually annotated by BRENDA team
Roessner, C.A.; Williams, H.J.; Scott, A.I.
Genetically engineered production of 1-desmethylcobyrinic acid, 1-desmethylcobyrinic acid a,c-diamide, and cobyrinic acid a,c-diamide in Escherichia coli implies a role for CbiD in C-1 methylation in the anaerobic pathway to cobalamin
J. Biol. Chem.
280
16748-16753
2005
Salmonella enterica
Manually annotated by BRENDA team