6.3.4.22: tRNAIle2-agmatinylcytidine synthase

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For detailed information about tRNAIle2-agmatinylcytidine synthase, go to the full flat file.

Reaction

Synonyms

AF2259, TiaS, tRNAIle-2-agmatinylcytidine synthetase, tRNAIle-agm2C synthetase, tRNAIle-agmatidine synthetase

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.4 Other carbon-nitrogen ligases

                6.3.4.22 tRNAIle2-agmatinylcytidine synthase

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Results	in table
1809	AA Sequence
3	Cloned(Commentary)
2	Crystallization (Commentary)
2	General Information
2	IC50 Value
2	Inhibitors
3	kcat/KM [mM/s]
3	KM Value [mM]
2	Metals/Ions
2	Natural Substrates/ Products (Substrates)
5	Organism
3	PDB ID
1	pH Optimum
1	Posttranslational Modification
28	Protein Variants
4	Purification (Commentary)
1	Reaction
5	Reference
4	Substrates and Products (Substrate)
16	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
3	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 6.3.4.22 - tRNAIle2-agmatinylcytidine synthase

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SYSTEMATIC NAME

IUBMB Comments

agmatine:[tRNAIle]-cytidine34 ligase

The enzyme from the archaeon Archaeoglobus fulgidus modifies the wobble base of the CAU anticodon of the archaeal tRNAIle2 at the oxo group in position 2 of cytidine34. This modification is crucial for accurate decoding of the genetic code. In bacteria EC 6.3.4.19, tRNAIle-lysidine synthase, catalyses the modification of [tRNAIle2]-cytidine34 to [tRNAIle2]-lysidine34 .