6.3.2.37: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-D-lysine ligase

This is an abbreviated version!
For detailed information about UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-D-lysine ligase, go to the full flat file.

Reaction

Synonyms

D-lysine-adding enzyme, MurE, MurE synthetase, UDP-MurNAc-L-Ala-D-Glu:D-Lys ligase

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.37 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-D-lysine ligase

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Results	in table
51	AA Sequence
1	Cloned(Commentary)
1	Cofactor
1	Inhibitors
1	Metals/Ions
1	Molecular Weight [Da]
24	Organism
2	PDB ID
1	pH Optimum
1	Purification (Commentary)
1	Reaction
2	Reference
4	Substrates and Products (Substrate)
6	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 6.3.2.37 - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-D-lysine ligase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

UDP-N-acetylmuramoyl-L-Ala-D-Glu + D-Lys + ATP

UDP-N-acetylmuramoyl-L-Ala-D-Glu-D-Lys + ADP + phosphate

2 entries

UDP-N-acetylmuramoyl-L-Ala-D-Glu + L-Lys + ATP

UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys + ADP + phosphate

Thermotoga maritima

-

-

674565

-

-

?

UDP-N-acetylmuramoyl-L-Ala-D-Glu + meso-diaminopimelic acid + ATP

UDP-N-acetylmuramoyl-L-Ala-D-Glu-meso-diaminopimelic acid + ADP + phosphate

Thermotoga maritima

-

meso-diaminopimelic acid is added to UDP-N-acetylmuramoyl-L-Ala-D-Glu with 10% efficiency relative to L-lysine

674565

-

-

?

UDP-N-acetylmuramoyl-L-Ala-D-Glu + D-Lys + ATP

UDP-N-acetylmuramoyl-L-Ala-D-Glu-D-Lys + ADP + phosphate

Thermotoga maritima

-

D-lysine is added to UDP-N-acetylmuramoyl-L-Ala-D-Glu with 25% efficiency relative to L-lysine

674565

-

-

?

UDP-N-acetylmuramoyl-L-Ala-D-Glu + D-Lys + ATP

UDP-N-acetylmuramoyl-L-Ala-D-Glu-D-Lys + ADP + phosphate

Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589

-

D-lysine is added to UDP-N-acetylmuramoyl-L-Ala-D-Glu with 25% efficiency relative to L-lysine

674565

-

-

?