6.3.2.14: enterobactin synthase

This is an abbreviated version!
For detailed information about enterobactin synthase, go to the full flat file.

Reaction

6 ATP + 3 2,3-dihydroxybenzoate + 3 L-serine =

Synonyms

2,3-Dihydroxy-N-benzoyl-L-serine synthetase, 2,3-Dihydroxybenzoylserine synthetase, DBS synthetase, DHBS synthase, EntE, N-(2,3-Dihydroxybenzoyl)-serine synthetase, Synthetase, 2,3-dihydroxybenzoylserine

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.14 enterobactin synthase

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Results	in table
1119	AA Sequence
1	CAS Registry Number
4	Cloned(Commentary)
1	Cofactor
1	General Information
2	Inhibitors
6	kcat/KM [mM/s]
1	Ki Value [mM]
8	KM Value [mM]
2	Metals/Ions
2	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
17	Organism
4	Pathway
1	pH Optimum
4	Purification (Commentary)
3	Reaction
2	Reaction Type
12	Reference
20	Substrates and Products (Substrate)
1	Subunits
8	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
7	Turnover Number [1/s]

Natural Substrates Products

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of the Enzyme Summary Page.

Natural Substrates Products on EC 6.3.2.14 - enterobactin synthase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

6 ATP + 3 2,3-dihydroxybenzoate + 3 L-serine

enterobactin + 6 AMP + 6 diphosphate

2 entries

ATP + 2,3-dihydroxybenzoate + L-serine

N-(2,3-dihydroxybenzoyl)-L-serine + AMP + diphosphate

2 entries

ATP + 2,3-dihydroxybenzoate + phosphopantetheinylated EntB

arylated EntB + AMP + diphosphate

Escherichia coli

P0ADI4, P10378, P11454

reaction of EntE

726950

-

-

?

ATP + arylated EntB + L-serine

enterobactin + AMP + diphosphate

Escherichia coli

P0ADI4, P10378, P11454

reaction of EntF

726950

-

-

?

6 ATP + 3 2,3-dihydroxybenzoate + 3 L-serine

enterobactin + 6 AMP + 6 diphosphate

Escherichia coli

P0ADI4, P10378, P11454

overall reaction. EntB, -D, -E, and -F are then required to catalyze the ATP-dependent assembly of enterobactin from three molecules each of 2,3-dihydroxybenzoate and L-serine. EntD, a phosphopantetheinyl transferase, uses coenzyme A to phosphopantetheinylate S245 of the aryl carrier protein domain of EntB. Next, EntE catalyzes the transfer of 2,3-dihydroxybenzoate onto the phosphopantetheinylated (holo) EntB to yield the covalently arylated EntB. Finally, arylated EntB, ATP, and L-serine are used as substrates for the reaction catalyzed by EntF to generate enterobactin

726950

-

-

?

6 ATP + 3 2,3-dihydroxybenzoate + 3 L-serine

enterobactin + 6 AMP + 6 diphosphate

Escherichia coli

P0ADI4, P10378, P11454

overall reaction. EntB, -D, -E, and -F are then required to catalyze the ATP-dependent assembly of enterobactin from three molecules each of 2,3-dihydroxybenzoate and L-serine. EntD, a phosphopantetheinyl transferase, uses coenzyme A to phosphopantetheinylate S245 of the aryl carrier protein domain of EntB. Next, EntE catalyzes the transfer of 2,3-dihydroxybenzoate onto the phosphopantetheinylated (holo)EntB to yield the covalently arylated EntB. Finally, arylated EntB, ATP, and L-serine are used as substrates for the reaction catalyzed by EntF to generate enterobactin

726950

-

-

?

ATP + 2,3-dihydroxybenzoate + L-serine

N-(2,3-dihydroxybenzoyl)-L-serine + AMP + diphosphate

Escherichia coli

-

component of enterobactin synthetase activity that specifically transfers the dihydroxybenzoate acyl group onto holo-entB

649843

-

649843

?

ATP + 2,3-dihydroxybenzoate + L-serine

N-(2,3-dihydroxybenzoyl)-L-serine + AMP + diphosphate

Escherichia coli

-

component of enterobactin synthetase activity that specifically transfers the dihydroxybenzoate acyl group onto holo-entB

653649

-

653649

?