6.3.2.14: enterobactin synthase
This is an abbreviated version!
For detailed information about enterobactin synthase, go to the full flat file.
Reaction
6 ATP + 3 2,3-dihydroxybenzoate + 3 L-serine = + 6 AMP + 6 diphosphate
Synonyms
2,3-Dihydroxy-N-benzoyl-L-serine synthetase, 2,3-Dihydroxybenzoylserine synthetase, DBS synthetase, DHBS synthase, EntE, N-(2,3-Dihydroxybenzoyl)-serine synthetase, Synthetase, 2,3-dihydroxybenzoylserine
ECTree
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Substrates Products
Substrates Products on EC 6.3.2.14 - enterobactin synthase
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REACTION DIAGRAM
ATP + 2,3-dihydroxybenzoate + L-Ser
Products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-Ser
ATP + 2,3-dihydroxybenzoate + L-serine
N-(2,3-dihydroxybenzoyl)-L-serine + AMP + diphosphate
ATP + 2,3-dihydroxybenzoate + phosphopantetheinylated EntB
arylated EntB + AMP + diphosphate
reaction of EntE
-
-
?
ATP + 3-hydroxybenzoate + phosphopantetheinylated EntB
arylated EntB + AMP + diphosphate
reaction of EntE
-
-
?
ATP + 4-aminosalicylic acid + phosphopantetheinylated EntB
arylated EntB + AMP + diphosphate
reaction of EntE
-
-
?
ATP + arylated EntB + L-serine
enterobactin + AMP + diphosphate
reaction of EntF
-
-
?
ATP + salicylic acid + phosphopantetheinylated EntB
arylated EntB + AMP + diphosphate
reaction of EntE
-
-
?
enterobactin + 6 AMP + 6 diphosphate
overall reaction. EntB, -D, -E, and -F are then required to catalyze the ATP-dependent assembly of enterobactin from three molecules each of 2,3-dihydroxybenzoate and L-serine. EntD, a phosphopantetheinyl transferase, uses coenzyme A to phosphopantetheinylate S245 of the aryl carrier protein domain of EntB. Next, EntE catalyzes the transfer of 2,3-dihydroxybenzoate onto the phosphopantetheinylated (holo) EntB to yield the covalently arylated EntB. Finally, arylated EntB, ATP, and L-serine are used as substrates for the reaction catalyzed by EntF to generate enterobactin
-
-
?
6 ATP + 3 2,3-dihydroxybenzoate + 3 L-serine
enterobactin + 6 AMP + 6 diphosphate
overall reaction. EntB, -D, -E, and -F are then required to catalyze the ATP-dependent assembly of enterobactin from three molecules each of 2,3-dihydroxybenzoate and L-serine. EntD, a phosphopantetheinyl transferase, uses coenzyme A to phosphopantetheinylate S245 of the aryl carrier protein domain of EntB. Next, EntE catalyzes the transfer of 2,3-dihydroxybenzoate onto the phosphopantetheinylated (holo)EntB to yield the covalently arylated EntB. Finally, arylated EntB, ATP, and L-serine are used as substrates for the reaction catalyzed by EntF to generate enterobactin
-
-
?
Products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-Ser
-
-
-
?
ATP + 2,3-dihydroxybenzoate + L-Ser
Products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-Ser
-
-
-
-
?
ATP + 2,3-dihydroxybenzoate + L-Ser
Products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-Ser
-
specific for the substrates
-
-
?
ATP + 2,3-dihydroxybenzoate + L-Ser
Products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-Ser
-
specific for the substrates
-
-
?
N-(2,3-dihydroxybenzoyl)-L-serine + AMP + diphosphate
-
-
-
?
ATP + 2,3-dihydroxybenzoate + L-serine
N-(2,3-dihydroxybenzoyl)-L-serine + AMP + diphosphate
-
-
-
?
ATP + 2,3-dihydroxybenzoate + L-serine
N-(2,3-dihydroxybenzoyl)-L-serine + AMP + diphosphate
-
component of enterobactin synthetase activity that specifically transfers the dihydroxybenzoate acyl group onto holo-entB
-
?
ATP + 2,3-dihydroxybenzoate + L-serine
N-(2,3-dihydroxybenzoyl)-L-serine + AMP + diphosphate
-
component of enterobactin synthetase activity that specifically transfers the dihydroxybenzoate acyl group onto holo-entB
-
?
additional information
?
-
no activity with 4-aminobenzoic acid
-
-
?
additional information
?
-
no activity with 4-aminobenzoic acid
-
-
?
additional information
?
-
no activity with 4-aminobenzoic acid
-
-
?