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6.3.2.14: enterobactin synthase

This is an abbreviated version!
For detailed information about enterobactin synthase, go to the full flat file.

Reaction

6 ATP + 3 2,3-dihydroxybenzoate + 3 L-serine =

enterobactin
+ 6 AMP + 6 diphosphate

Synonyms

2,3-Dihydroxy-N-benzoyl-L-serine synthetase, 2,3-Dihydroxybenzoylserine synthetase, DBS synthetase, DHBS synthase, EntE, N-(2,3-Dihydroxybenzoyl)-serine synthetase, Synthetase, 2,3-dihydroxybenzoylserine

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.2 Acid—amino-acid ligases (peptide synthases)
                6.3.2.14 enterobactin synthase

Substrates Products

Substrates Products on EC 6.3.2.14 - enterobactin synthase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
6 ATP + 3 2,3-dihydroxybenzoate + 3 L-serine
enterobactin + 6 AMP + 6 diphosphate
show the reaction diagram
ATP + 2,3-dihydroxybenzoate + L-Ser
Products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-Ser
show the reaction diagram
ATP + 2,3-dihydroxybenzoate + L-serine
N-(2,3-dihydroxybenzoyl)-L-serine + AMP + diphosphate
show the reaction diagram
ATP + 2,3-dihydroxybenzoate + phosphopantetheinylated EntB
arylated EntB + AMP + diphosphate
show the reaction diagram
reaction of EntE
-
-
?
ATP + 3-hydroxybenzoate + phosphopantetheinylated EntB
arylated EntB + AMP + diphosphate
show the reaction diagram
reaction of EntE
-
-
?
ATP + 4-aminosalicylic acid + phosphopantetheinylated EntB
arylated EntB + AMP + diphosphate
show the reaction diagram
reaction of EntE
-
-
?
ATP + arylated EntB + L-serine
enterobactin + AMP + diphosphate
show the reaction diagram
reaction of EntF
-
-
?
ATP + salicylic acid + phosphopantetheinylated EntB
arylated EntB + AMP + diphosphate
show the reaction diagram
reaction of EntE
-
-
?
additional information
?
-