6.3.2.14: enterobactin synthase

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For detailed information about enterobactin synthase, go to the full flat file.

Reaction

6 ATP + 3 2,3-dihydroxybenzoate + 3 L-serine =

Synonyms

2,3-Dihydroxy-N-benzoyl-L-serine synthetase, 2,3-Dihydroxybenzoylserine synthetase, DBS synthetase, DHBS synthase, EntE, N-(2,3-Dihydroxybenzoyl)-serine synthetase, Synthetase, 2,3-dihydroxybenzoylserine

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.14 enterobactin synthase

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1119	AA Sequence
1	CAS Registry Number
4	Cloned(Commentary)
1	Cofactor
1	General Information
2	Inhibitors
6	kcat/KM [mM/s]
1	Ki Value [mM]
8	KM Value [mM]
2	Metals/Ions
2	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
17	Organism
4	Pathway
1	pH Optimum
4	Purification (Commentary)
3	Reaction
2	Reaction Type
12	Reference
20	Substrates and Products (Substrate)
1	Subunits
8	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
7	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 6.3.2.14 - enterobactin synthase

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SYSTEMATIC NAME

IUBMB Comments

2,3-dihydroxybenzoate:L-serine ligase

This enzyme complex catalyses the conversion of three molecules each of 2,3-dihydroxybenzoate and L-serine to form the siderophore enterobactin. In Escherichia coli the complex is formed by EntB (an aryl carrier protein that has to be activated by 4'-phosphopantetheine), EntD (a phosphopantetheinyl transferase that activates EntB), EntE (catalyses the ATP-dependent condensation of 2,3-dihydroxybenzoate and holo-EntB to form the covalently arylated form of EntB), and EntF (a four domain protein that catalyses the activation of L-serine by ATP, the condensation of the activated L-serine with the activated 2,3-dihydroxybenzoate, and the trimerization of three such moieties to a single enterobactin molecule).