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6.2.1.B11: carboxylic acid-CoA ligase (NDP-forming)

This is an abbreviated version!
For detailed information about carboxylic acid-CoA ligase (NDP-forming), go to the full flat file.

Word Map on EC 6.2.1.B11

Reaction

NTP
+
a carboxylate
 +
CoA
=
NDP
 +
phosphate
 +
an acyl-CoA

Synonyms

ACD, acetyl CoA synthetase (ADP forming), acetyl coenzyme A synthetase (ADP forming), Acetyl-CoA synthetase (ADP-forming), ACSIIITk, acyl-CoA synthetase (NDP forming), ADP-forming acetyl coenzyme A synthetase, AF1211, AF1938, ckcACD1, EhACD, Kcr_0198, MJ0590, More, NDP-forming acyl-CoA synthetase, TK0944/TK0943 protein

ECTree

     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.B11 carboxylic acid-CoA ligase (NDP-forming)

KM Value

KM Value on EC 6.2.1.B11 - carboxylic acid-CoA ligase (NDP-forming)

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.34 - 14
acetate
0.01 - 0.04
acetyl-CoA
0.007 - 1.6
ADP
0.03 - 12
ATP
0.0056 - 1.6
CoA
1.9
GDP
pH 7.3, 37°C, acetate-forming direction, with acetyl-CoA
10
GTP
pH 7.3, 37°C, acetyl-CoA-forming direction, with acetate
1.24
indole-3-acetate
pH 8.0, 55°C
0.11 - 2.5
phenylacetate
0.017
phenylacetyl-CoA
pH 8.0, 55°C
0.11 - 1.8
phosphate
29
propionate
pH 7.3, 37°C, propionyl-CoA-forming direction, with propionate
0.032
propionyl-CoA
pH 7.3, 37°C, propionate-forming direction, with propionyl-CoA
additional information
acetate