6.2.1.B11: carboxylic acid-CoA ligase (NDP-forming)

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For detailed information about carboxylic acid-CoA ligase (NDP-forming), go to the full flat file.

Word Map on EC 6.2.1.B11

6.2.1.B11

archaeon

pyrococcus

hyperthermophilic

acetyl-coa

furiosus

acetyl-coenzyme

heterotetramer

Reaction

Synonyms

ACD, acetyl CoA synthetase (ADP forming), acetyl coenzyme A synthetase (ADP forming), Acetyl-CoA synthetase (ADP-forming), ACSIIITk, acyl-CoA synthetase (NDP forming), ADP-forming acetyl coenzyme A synthetase, AF1211, AF1938, ckcACD1, EhACD, Kcr_0198, MJ0590, More, NDP-forming acyl-CoA synthetase, TK0944/TK0943 protein

ECTree

6 Ligases

6.2 Forming carbon-sulfur bonds

6.2.1 Acid-thiol ligases

6.2.1.B11 carboxylic acid-CoA ligase (NDP-forming)

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Results	in table
5	AA Sequence
4	Cloned(Commentary)
5	Cofactor
2	Crystallization (Commentary)
6	General Information
2	IC50 Value
11	Inhibitors
33	kcat/KM [mM/s]
37	KM Value [mM]
20	Metals/Ions
9	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
9	Organism
2	Pathway
5	pH Optimum
1	pH Range
1	Posttranslational Modification
4	Purification (Commentary)
1	Reaction
8	Reference
1	Source Tissue
50	Substrates and Products (Substrate)
10	Subunits
30	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Range [°C]
5	Temperature Stability [°C]
33	Turnover Number [1/s]

General Information

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General Information on EC 6.2.1.B11 - carboxylic acid-CoA ligase (NDP-forming)

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evolution

Candidatus Korarchaeum cryptofilum

B1L3C9

the ACD enzymes are considered to be primordial enzymes of ATP synthesis in the early evolution of life. The structure reveals a unique arrangement of the ACD subunits alpha and beta within an alpha2beta2-heterotetrameric complex. This arrangement significantly differs from other members of the superfamily. Residues Ser160alpha and Asp351alpha' are highly conserved throughout the ACD superfamily

746318

physiological function

5 entries