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6.2.1.B11: carboxylic acid-CoA ligase (NDP-forming)

This is an abbreviated version!
For detailed information about carboxylic acid-CoA ligase (NDP-forming), go to the full flat file.

Word Map on EC 6.2.1.B11

Reaction

NTP
+
a carboxylate
 +
CoA
=
NDP
 +
phosphate
 +
an acyl-CoA

Synonyms

ACD, acetyl CoA synthetase (ADP forming), acetyl coenzyme A synthetase (ADP forming), Acetyl-CoA synthetase (ADP-forming), ACSIIITk, acyl-CoA synthetase (NDP forming), ADP-forming acetyl coenzyme A synthetase, AF1211, AF1938, ckcACD1, EhACD, Kcr_0198, MJ0590, More, NDP-forming acyl-CoA synthetase, TK0944/TK0943 protein

ECTree

     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.B11 carboxylic acid-CoA ligase (NDP-forming)

Inhibitors

Inhibitors on EC 6.2.1.B11 - carboxylic acid-CoA ligase (NDP-forming)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
acetyl phosphate
-
AMP
slight inhibition
ATP
ATP inhibits the acetate-forming direction of the reaction, with 50% inhibitory concentration of 0.81 mM, which is in the range of its physiological concentration. Diphosphate displays mixed inhibition versus each of the three substrates, acetyl-CoA, ADP, and phosphate. No inhibition by lactate and pyruvate
D-fructose 1,6-bisphosphate
-
D-fructose 6-phosphate
-
D-glucose 6-phosphate
-
diphosphate
diphosphate inhibits the acetate-forming direction of the reaction, with 50% inhibitory concentration of 0.75 mM, which is in the range of its physiological concentration. ATP displays mixed inhibition versus each of the three substrates, acetyl-CoA, ADP, and phosphate
glyoxylate
inhibits the activity in the acetate-forming direction