6.2.1.40: 4-hydroxybutyrate-CoA ligase (AMP-forming)
This is an abbreviated version!
For detailed information about 4-hydroxybutyrate-CoA ligase (AMP-forming), go to the full flat file.
Word Map on EC 6.2.1.40
-
6.2.1.40
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proton-coupled
-
caco-2
-
slc36a1
-
3-hydroxypropionate/4-hydroxybutyrate
-
crotonyl-coa
-
4-hydroxybutyryl-coa
-
dehydratase
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chemolithoautotrophically
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metallosphaera
-
sedula
-
succinyl-coa
-
laevis
-
h+-coupled
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thermoacidophilic
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sulfolobales
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neutrophilus
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thermoproteus
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heterotroph
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l-3hproline
-
symport
-
thermoproteales
-
transepithelial
- 6.2.1.40
-
proton-coupled
-
caco-2
-
slc36a1
-
3-hydroxypropionate/4-hydroxybutyrate
- crotonyl-coa
- 4-hydroxybutyryl-coa
-
dehydratase
-
chemolithoautotrophically
-
metallosphaera
- sedula
- succinyl-coa
-
laevis
-
h+-coupled
-
thermoacidophilic
- sulfolobales
- neutrophilus
-
thermoproteus
-
heterotroph
-
l-3hproline
-
symport
- thermoproteales
-
transepithelial
Reaction
Synonyms
4-hydroxybutyrate-CoA ligase (AMP forming), 4-hydroxybutyrate-CoA synthetase, Msed_0394, Msed_0406, Msed_1353, Tneu_0420
ECTree
6.2.1.40 4-hydroxybutyrate-CoA ligase (AMP-forming)Advanced search results
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results (Substrates Products
Substrates Products on EC 6.2.1.40 - 4-hydroxybutyrate-CoA ligase (AMP-forming)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + 3-hydroxypropionate + CoA
AMP + diphosphate + 3-hydroxypropionyl-CoA
9% of the activity compared to 4-hydroxybutanoate
-
-
?
ATP + 3-hydroxybutyrate + CoA
AMP + diphosphate + 3-hydroxybutyryl-CoA
8% of the activity compared to 4-hydroxybutanoate
-
-
?
ATP + 3-hydroxybutyrate + CoA
AMP + diphosphate + 3-hydroxybutyryl-CoA
8% of the activity compared to 4-hydroxybutanoate
-
-
?
ATP + 4-hydroxybutanoate + CoA
AMP + diphosphate + 4-hydroxybutanoyl-CoA
-
-
-
?
ATP + 4-hydroxybutanoate + CoA
AMP + diphosphate + 4-hydroxybutanoyl-CoA
the enzyme is involved in the 3-hydroxypropionate/4-hydroxybutyrate cycle
-
-
?
ATP + 4-hydroxybutanoate + CoA
AMP + diphosphate + 4-hydroxybutanoyl-CoA
the enzyme has a clear preference for unsubstituted straight chain organic acids with a chain length of four or five carbons. No activity is detected with the six-carbon hexanoic acid
-
-
?
ATP + 4-hydroxybutanoate + CoA
AMP + diphosphate + 4-hydroxybutanoyl-CoA
tzhe enzyme is also a promiscuous acetate/propionate ligase
-
-
?
ATP + 4-hydroxybutanoate + CoA
AMP + diphosphate + 4-hydroxybutanoyl-CoA
wild-type enzyme shows no activity, mutant enzyme W424G shows activity
-
-
?
ATP + 4-hydroxybutanoate + CoA
AMP + diphosphate + 4-hydroxybutanoyl-CoA
the enzyme is involved in the 3-hydroxypropionate/4-hydroxybutyrate carbon fixation pathway. The flux between the succinate and acetyl-CoA branches in the 3-hydroxypropionate/4-hydroxybutyrate carbon fixation pathway is governed by 4-hydroxybutyrate-CoA ligase, possibly regulated posttranslationally by the protein acetyltransferase
-
-
?
ATP + 4-hydroxybutanoate + CoA
AMP + diphosphate + 4-hydroxybutanoyl-CoA
the enzyme is involved in the 3-hydroxypropionate/4-hydroxybutyrate cycle
-
-
?
ATP + 4-hydroxybutanoate + CoA
AMP + diphosphate + 4-hydroxybutanoyl-CoA
the enzyme has a clear preference for unsubstituted straight chain organic acids with a chain length of four or five carbons. No activity is detected with the six-carbon hexanoic acid
-
-
?
ATP + 4-hydroxybutanoate + CoA
AMP + diphosphate + 4-hydroxybutanoyl-CoA
tzhe enzyme is also a promiscuous acetate/propionate ligase
-
-
?
ATP + 4-hydroxybutanoate + CoA
AMP + diphosphate + 4-hydroxybutanoyl-CoA
-
-
-
?
ATP + 4-hydroxybutanoate + CoA
AMP + diphosphate + 4-hydroxybutanoyl-CoA
the enzyme is involved in the 3-hydroxypropionate/4-hydroxybutyrate carbon fixation pathway. The flux between the succinate and acetyl-CoA branches in the 3-hydroxypropionate/4-hydroxybutyrate carbon fixation pathway is governed by 4-hydroxybutyrate-CoA ligase, possibly regulated posttranslationally by the protein acetyltransferase
-
-
?
ATP + 4-hydroxybutanoate + CoA
AMP + diphosphate + 4-hydroxybutanoyl-CoA
wild-type enzyme shows no activity, mutant enzyme W424G shows activity
-
-
?
ATP + 4-hydroxybutanoate + CoA
AMP + diphosphate + 4-hydroxybutanoyl-CoA
-
-
-
?
ATP + 4-hydroxybutanoate + CoA
AMP + diphosphate + 4-hydroxybutanoyl-CoA
the enzyme is involved in autotrophic carbon fixation
-
-
?
ATP + 4-hydroxybutanoate + CoA
AMP + diphosphate + 4-hydroxybutanoyl-CoA
-
-
-
?
ATP + 4-hydroxybutanoate + CoA
AMP + diphosphate + 4-hydroxybutanoyl-CoA
the enzyme is involved in autotrophic carbon fixation
-
-
?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
13% of the activity compared to 4-hydroxybutanoate
-
-
?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
13% of the activity compared to 4-hydroxybutanoate
-
-
?
ATP + crotonate + CoA
AMP + diphosphate + crotonyl-CoA
22% of the activity compared to 4-hydroxybutanoate
-
-
?
ATP + crotonate + CoA
AMP + diphosphate + crotonyl-CoA
22% of the activity compared to 4-hydroxybutanoate
-
-
?
