6.2.1.40: 4-hydroxybutyrate-CoA ligase (AMP-forming)

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For detailed information about 4-hydroxybutyrate-CoA ligase (AMP-forming), go to the full flat file.

Word Map on EC 6.2.1.40

6.2.1.40

proton-coupled

caco-2

slc36a1

3-hydroxypropionate/4-hydroxybutyrate

crotonyl-coa

4-hydroxybutyryl-coa

dehydratase

chemolithoautotrophically

metallosphaera

sedula

succinyl-coa

laevis

h+-coupled

thermoacidophilic

sulfolobales

neutrophilus

thermoproteus

heterotroph

l-3hproline

symport

thermoproteales

transepithelial

Reaction

Synonyms

4-hydroxybutyrate-CoA ligase (AMP forming), 4-hydroxybutyrate-CoA synthetase, Msed_0394, Msed_0406, Msed_1353, Tneu_0420

ECTree

6 Ligases

6.2 Forming carbon-sulfur bonds

6.2.1 Acid-thiol ligases

6.2.1.40 4-hydroxybutyrate-CoA ligase (AMP-forming)

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Results	in table
59	AA Sequence
4	Cloned(Commentary)
2	Expression
8	General Information
4	kcat/KM [mM/s]
5	KM Value [mM]
3	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
16	Organism
6	Pathway
3	pH Optimum
2	Protein Variants
3	Purification (Commentary)
1	Reaction
10	Reference
12	Source Tissue
4	Specific Activity [micromol/min/mg]
23	Substrates and Products (Substrate)
6	Subunits
18	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
4	Turnover Number [1/s]

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Reference on EC 6.2.1.40 - 4-hydroxybutyrate-CoA ligase (AMP-forming)

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725542

Hawkins, A.S.; Han, Y.; Bennett, R.K.; Adams, M.W.; Kelly, R.M.

Role of 4-hydroxybutyrate-CoA synthetase in the CO2 fixation cycle in thermoacidophilic archaea

J. Biol. Chem.

288

4012-4022

2013

Metallosphaera sedula (A4YDR9), Metallosphaera sedula (A4YDT1), Metallosphaera sedula (A4YGF9), Metallosphaera sedula, Metallosphaera sedula DSM 5348 (A4YDR9), Metallosphaera sedula DSM 5348 (A4YDT1), Metallosphaera sedula DSM 5348 (A4YGF9)

23258541

726748

Hawkins, A.B.; Adams, M.W.; Kelly, R.M.

Conversion of 4-hydroxybutyrate to acetyl coenzyme A and its anapleurosis in the Metallosphaera sedula 3-hydroxypropionate/4-hydroxybutyrate carbon fixation pathway

Appl. Environ. Microbiol.

2536-2545

2014

Metallosphaera sedula (A4YDT1), Metallosphaera sedula, Metallosphaera sedula DSM 5348 (A4YDT1)

24532060

727749

Ramos-Vera, W.H.; Labonte, V.; Weiss, M.; Pauly, J.; Fuchs, G.

Regulation of autotrophic CO2 fixation in the archaeon Thermoproteus neutrophilus

J. Bacteriol.

192

5329-5340

2010

Pyrobaculum neutrophilum (B1YBY4), Pyrobaculum neutrophilum DSM 2338 (B1YBY4)

20693323

727751

Ramos-Vera, W.H.; Weiss, M.; Strittmatter, E.; Kockelkorn, D.; Fuchs, G.

Identification of missing genes and enzymes for autotrophic carbon fixation in crenarchaeota

J. Bacteriol.

193

1201-1211

2011

Pyrobaculum neutrophilum (B1YBY4), Pyrobaculum neutrophilum DSM 2338 (B1YBY4)

21169482