6.2.1.23: dicarboxylate-CoA ligase

This is an abbreviated version!
For detailed information about dicarboxylate-CoA ligase, go to the full flat file.

Reaction

Synonyms

Carboxylyl-CoA synthetase

ECTree

     6 Ligases

         6.2 Forming carbon-sulfur bonds

             6.2.1 Acid-thiol ligases

                6.2.1.23 dicarboxylate-CoA ligase

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Results	in table
70	AA Sequence
1	CAS Registry Number
2	General Stability
2	Inhibitors
2	KM Value [mM]
2	Localization
1	Natural Substrates/ Products (Substrates)
1	Organism
1	pH Optimum
1	pH Range
1	Reaction
1	Reaction Type
1	Reference
2	Source Tissue
10	Substrates and Products (Substrate)
1	Synonyms
1	Systematic Name

Substrates Products

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Substrates Products on EC 6.2.1.23 - dicarboxylate-CoA ligase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

ATP + decanedioic acid + CoA

AMP + diphosphate + decanedioyl-CoA

Rattus norvegicus

-

-

701

-

-

?

ATP + dodec-2-enedioic acid + CoA

AMP + diphosphate + dodec-2-enedioyl-CoA

Rattus norvegicus

-

i.e. traumatic acid, at 40% of the activity relative to dodecanedioic acid

701

-

-

?

ATP + dodecanedioic acid + CoA

AMP + diphosphate + dodecanedioyl-CoA

Rattus norvegicus

-

highest activity with dodecandioic acid , ATP cannot be replaced by GTP

701

-

701

?

ATP + heptanedioic acid + CoA

AMP + diphosphate + heptanedioyl-CoA

Rattus norvegicus

-

-

701

-

-

?

ATP + hexadecanedioic acid + CoA

AMP + diphosphate + hexadecanedioyl-CoA

Rattus norvegicus

-

-

701

-

-

?

ATP + hexanedioic acid + CoA

AMP + diphosphate + hexanedioyl-CoA

Rattus norvegicus

-

-

701

-

-

?

ATP + octanedioic acid + CoA

AMP + diphosphate + octanedioyl-CoA

Rattus norvegicus

-

-

701

-

-

?

ATP + pentanedioic acid + CoA

AMP + diphosphate + pentanedioyl-CoA

Rattus norvegicus

-

-

701

-

-

?

ATP + tetradecanedioic acid + CoA

AMP + diphosphate + tetradecanedioyl-CoA

Rattus norvegicus

-

-

701

-

-

?

additional information

?

-

Rattus norvegicus

-

the dicarboxylyl-CoA synthetase appears to catalyze an essential step in the degradation of dicarboxylic acids

701

-

-

?