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IUBMB CommentsActs on dicarboxylic acids of chain length C5 to C16; the best substrate is dodecanedioic acid.
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
Carboxylyl-CoA synthetase,
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Carboxylyl-CoA synthetase
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ATP + an alpha,omega-dicarboxylate + CoA = AMP + diphosphate + an omega-carboxyacyl-CoA
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Acid-thiol ligation
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omega-dicarboxylate:CoA ligase (AMP-forming)
Acts on dicarboxylic acids of chain length C5 to C16; the best substrate is dodecanedioic acid.
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ATP + decanedioic acid + CoA
AMP + diphosphate + decanedioyl-CoA
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ATP + dodec-2-enedioic acid + CoA
AMP + diphosphate + dodec-2-enedioyl-CoA
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i.e. traumatic acid, at 40% of the activity relative to dodecanedioic acid
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ATP + dodecanedioic acid + CoA
AMP + diphosphate + dodecanedioyl-CoA
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highest activity with dodecandioic acid , ATP cannot be replaced by GTP
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ATP + heptanedioic acid + CoA
AMP + diphosphate + heptanedioyl-CoA
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ATP + hexadecanedioic acid + CoA
AMP + diphosphate + hexadecanedioyl-CoA
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ATP + hexanedioic acid + CoA
AMP + diphosphate + hexanedioyl-CoA
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ATP + octanedioic acid + CoA
AMP + diphosphate + octanedioyl-CoA
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ATP + pentanedioic acid + CoA
AMP + diphosphate + pentanedioyl-CoA
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ATP + tetradecanedioic acid + CoA
AMP + diphosphate + tetradecanedioyl-CoA
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additional information
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the dicarboxylyl-CoA synthetase appears to catalyze an essential step in the degradation of dicarboxylic acids
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additional information
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the dicarboxylyl-CoA synthetase appears to catalyze an essential step in the degradation of dicarboxylic acids
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diphosphate
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product inhibition
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2.5
dodecanedioic acid
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7.4 - 8.5
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pH 7.4: 40% of maximal activity, pH 8.5: 70% of maximal activity with dodecanedioic acid
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brenda
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additional information
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no activity detected in kidney, jejunum, heart, lung, skeletal muscle, smooth muscle, cerebrum, brain stem
brenda
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brenda
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A0A844THZ9_9BRAD
560
0
60361
TrEMBL
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A0A849IF27_9HYPH
564
0
60925
TrEMBL
-
A0A5E8VBW5_9BRAD
560
0
60243
TrEMBL
-
A0A410V120_9BRAD
558
0
60176
TrEMBL
-
A0A850J5I5_9BRAD
558
0
60197
TrEMBL
-
A0A5D3KCY2_9BRAD
560
0
60335
TrEMBL
-
A0A7T7VBD8_9BRAD
560
0
60221
TrEMBL
-
A0A7G6U7W6_9BRAD
567
1
61008
TrEMBL
-
A0A4E0RAG5_9BRAD
564
0
61055
TrEMBL
-
A0A7C2M255_9HYPH
556
0
60886
TrEMBL
-
A0A4Q4KH15_BRAEL
562
0
61061
TrEMBL
-
A0A4Y9UZE4_9BRAD
560
0
60386
TrEMBL
-
A0A4Q0R712_9BRAD
560
0
60490
TrEMBL
-
A0A5P6P805_9BRAD
553
0
59459
TrEMBL
-
A0A525JDA9_BRASZ
564
0
61174
TrEMBL
-
A0A4D7BKC8_9HYPH
553
0
59603
TrEMBL
-
A0A3S0HTJ4_9BRAD
553
1
59825
TrEMBL
-
A0A3S0F943_9BRAD
475
0
51183
TrEMBL
-
A0A6P1BX59_9BRAD
563
0
61025
TrEMBL
-
A0A6P1RJJ7_9BRAD
560
0
60458
TrEMBL
-
A0A850E3V8_9BRAD
567
1
61142
TrEMBL
-
A0A4U6RUI1_BRAEL
561
0
61036
TrEMBL
-
A0A6G8ZRQ6_9BRAD
560
0
60273
TrEMBL
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A0A537UVQ7_9PROT
526
0
57052
TrEMBL
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A0A7C9RI37_9BRAD
560
0
60932
TrEMBL
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A0A537S8A1_9PROT
558
0
60671
TrEMBL
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A0A3S0GC12_9BRAD
560
0
60921
TrEMBL
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A0A844SD69_9BRAD
562
0
61002
TrEMBL
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A0A4Y9LV31_9BRAD
560
0
60414
TrEMBL
-
A0A844S6K7_9BRAD
564
0
61005
TrEMBL
-
A0A7S7QKV2_9BRAD
561
0
60911
TrEMBL
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A0A845IUA5_BRAJP
560
0
60325
TrEMBL
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A0A3N6QFQ4_9BRAD
560
0
60604
TrEMBL
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A0A7Y6T2Z0_9BRAD
561
0
60983
TrEMBL
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A0A7S7Q193_9BRAD
560
0
60574
TrEMBL
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A0A525J8G0_BRASZ
562
0
60777
TrEMBL
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A0A7L8VSG2_9BRAD
560
0
60128
TrEMBL
-
A0A7S7W751_9BRAD
560
0
60461
TrEMBL
-
A0A537Q179_9PROT
557
0
60564
TrEMBL
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A0A850I7E7_9BRAD
561
0
60900
TrEMBL
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A0A7S9CS92_9BRAD
558
0
60744
TrEMBL
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A0A3N5MNC2_9HYPH
558
0
60593
TrEMBL
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A0A6G8TY06_9BRAD
560
0
60399
TrEMBL
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A0A8J4M8B8_9PROT
Acidicaldus sp
558
0
60149
TrEMBL
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A0A7S7ZHV0_9BRAD
558
0
60087
TrEMBL
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A0A5A7VSP1_9BRAD
550
0
60585
TrEMBL
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A0A7Y6STN3_9BRAD
562
0
61103
TrEMBL
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A0A7S9H0I8_9BRAD
560
0
60221
TrEMBL
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A0A7S7QGR1_9BRAD
562
0
61015
TrEMBL
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A0A6G9A5D8_9BRAD
560
0
60344
TrEMBL
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A0A5S4VYR2_9BRAD
557
0
60195
TrEMBL
-
A0A4U6BKG4_9BRAD
560
0
61008
TrEMBL
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A0A8I1UWH5_9BRAD
Afipia sp
560
0
60680
TrEMBL
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A0A418VD11_RHOPL
552
0
59711
TrEMBL
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A0A4D7QR69_9HYPH
552
0
59770
TrEMBL
-
A0A7Y4H3I7_9BRAD
557
0
60620
TrEMBL
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A0A5A7VW79_9BRAD
567
1
61424
TrEMBL
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A0A515KPV8_9BRAD
561
0
60701
TrEMBL
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A0A7Y4GTT2_9BRAD
564
0
61213
TrEMBL
-
A0A6G6ZBP2_9BRAD
562
0
60936
TrEMBL
-
A0A4V1KX99_9BRAD
560
0
60438
TrEMBL
-
A0A4Q5PFB4_9BRAD
555
0
59686
TrEMBL
-
A0A4Q0RPQ4_9BRAD
558
0
60234
TrEMBL
-
A0A4Y9KYZ1_9BRAD
560
0
60218
TrEMBL
-
A0A6N6SWA8_9HYPH
559
0
60815
TrEMBL
-
A0A516IZM4_9BRAD
553
0
59551
TrEMBL
-
A0A7S7Z186_9BRAD
562
0
61256
TrEMBL
-
A0A7S7U7G5_9BRAD
560
0
60157
TrEMBL
-
A0A4Y9NU04_9BRAD
560
0
60275
TrEMBL
-
A0A7Z0Q9N0_9BRAD
558
0
60199
TrEMBL
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freezing and thawing of liver homogenates strongly diminishes its activity within several h
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preincubation of fresh liver homogenate in the absence of substrate and cofactors leads to a loss of 75% of its activity within 30 min
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Vamecq, J.; de Hoffmann, E.; van Hoof, F.
The microsomal dicarboxylyl-CoA synthetase
Biochem. J.
230
683-693
1985
Rattus norvegicus
brenda
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