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6.2.1.23: dicarboxylate-CoA ligase

This is an abbreviated version!
For detailed information about dicarboxylate-CoA ligase, go to the full flat file.

Reaction

ATP
+
an alpha,omega-dicarboxylate
+
CoA
=
AMP
+
diphosphate
+
an omega-carboxyacyl-CoA

Synonyms

Carboxylyl-CoA synthetase

ECTree

     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.23 dicarboxylate-CoA ligase

General Stability

General Stability on EC 6.2.1.23 - dicarboxylate-CoA ligase

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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
freezing and thawing of liver homogenates strongly diminishes its activity within several h
-
preincubation of fresh liver homogenate in the absence of substrate and cofactors leads to a loss of 75% of its activity within 30 min
-