6.2.1.10: carboxylic acid-CoA ligase (GDP-forming)

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For detailed information about carboxylic acid-CoA ligase (GDP-forming), go to the full flat file.

Reaction

Synonyms

Acid-CoA ligase (GDP), Acid:CoA ligase (GDP), Acyl coenzyme A synthetase (GDP-forming), Acyl-CoA synthetase (GDP-forming), GTP-dependent acyl-CoA synthetase, Synthetase, acyl coenzyme A (guanosine diphosphate-forming)

ECTree

     6 Ligases

         6.2 Forming carbon-sulfur bonds

             6.2.1 Acid-thiol ligases

                6.2.1.10 carboxylic acid-CoA ligase (GDP-forming)

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Results	in table
1	CAS Registry Number
1	Cofactor
2	Inhibitors
6	KM Value [mM]
5	Localization
1	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
5	Organism
2	Pathway
1	Reaction
1	Reaction Type
5	Reference
5	Source Tissue
6	Substrates and Products (Substrate)
6	Synonyms
1	Systematic Name

Substrates Products

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Substrates Products on EC 6.2.1.10 - carboxylic acid-CoA ligase (GDP-forming)

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

GTP + butyrate + CoA

GDP + phosphate + butyryl-CoA

Rattus norvegicus

-

-

563

-

-

?

GTP + octanoate + CoA

GDP + phosphate + octanoyl-CoA

Rattus norvegicus

-

-

563

-

-

?

GTP + oleate + CoA

GDP + phosphate + oleoyl-CoA

Rattus norvegicus

-

-

563

-

-

?

GTP + palmitate + CoA

GDP + phosphate + palmitoyl-CoA

Rattus norvegicus

-

-

563

-

-

?

additional information

?

-

2 entries

additional information

?

-

Rattus norvegicus

-

the different specificity of the isolated GTP-dependent enzymes for fatty acid substrates results from their different lecithin contents

563

-

-

?

additional information

?

-

Rattus norvegicus

-

enzyme does not play an important role in the activation of fatty acids by uncoupled mitochondria

586

-

-

?