Information on EC 6.2.1.10 - carboxylic acid-CoA ligase (GDP-forming)

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The expected taxonomic range for this enzyme is: Rattus norvegicus

EC NUMBER
COMMENTARY hide
6.2.1.10
-
RECOMMENDED NAME
GeneOntology No.
carboxylic acid-CoA ligase (GDP-forming)
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
GTP + a carboxylate + CoA = GDP + phosphate + acyl-CoA
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acid-thiol ligation
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
carboxylic acid:CoA ligase (GDP-forming)
-
CAS REGISTRY NUMBER
COMMENTARY hide
37318-59-5
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
GTP + butyrate + CoA
GDP + phosphate + butyryl-CoA
show the reaction diagram
-
-
-
-
-
GTP + octanoate + CoA
GDP + phosphate + octanoyl-CoA
show the reaction diagram
-
-
-
-
-
GTP + oleate + CoA
GDP + phosphate + oleoyl-CoA
show the reaction diagram
-
-
-
-
-
GTP + palmitate + CoA
GDP + phosphate + palmitoyl-CoA
show the reaction diagram
-
-
-
-
-
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
enzyme does not play an important role in the activation of fatty acids by uncoupled mitochondria
-
-
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4'-phosphopantetheine
-
contains 1 M 4“-phosphopantetheine per 20000 g enzyme
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
F-
-
2 mM, complete inhibition
phosphate
-
5 mM, 70% inhibition
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.22
Butyrate
-
-
3.3
CoA
-
-
4.3
GTP
-
-
0.2
Octanoate
-
-
2.1
oleate
-
-
3.3
palmitate
-
-
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
20000
-
gel filtration