6.1.1.27: O-phospho-L-serine-tRNA ligase

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For detailed information about O-phospho-L-serine-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.27

6.1.1.27

cys-trnacys

methanogen

aminoacylation

archaea

sepcyss

cysteinyl-trna

sep-trna:cys-trna

o-phosphoserine

anticodons

aminoacyl-trnas

maripaludis

trna-dependent

cysteinyl-trnacys

selenocysteine

methanocaldococcus

jannaschii

phosphoserylation

pylrs

aarss

faithful

mazei

methanosarcina

gca

alpha4

web-based

biologists

phenylalanyl-trna

asnrs

ilers

biotechnology

Reaction

Synonyms

CysRS, Cysteinyl-tRNA synthetase, More, O-phosphoseryl-tRNA synthetase, phosphoseryl-tRNA synthetase, phosphoseryl-tRNA synthetases, SepRS, sepS

ECTree

6 Ligases

6.1 Forming carbon-oxygen bonds

6.1.1 Ligases forming aminoacyl-tRNA and related compounds

6.1.1.27 O-phospho-L-serine-tRNA ligase

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Results	in table
559	AA Sequence
1	Application
7	Cloned(Commentary)
13	Cofactor
5	Crystallization (Commentary)
22	KM Value [mM]
4	Metals/Ions
7	Molecular Weight [Da]
22	Natural Substrates/ Products (Substrates)
19	Organism
4	Pathway
2	PDB ID
4	pH Optimum
23	Protein Variants
8	Purification (Commentary)
2	Reaction
19	Reference
1	Specific Activity [micromol/min/mg]
43	Substrates and Products (Substrate)
10	Subunits
37	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
18	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 6.1.1.27 - O-phospho-L-serine-tRNA ligase

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O-phospho-L-serine:tRNACys ligase (AMP-forming)

In organisms like Archaeoglobus fulgidus lacking EC 6.1.1.16 (cysteine---tRNA ligase) for the direct Cys-tRNACys formation, Cys-tRNACys is produced by an indirect pathway, in which EC 6.1.1.27 (O-phosphoseryl-tRNA ligase) ligates O-phosphoserine to tRNACys, and EC 2.5.1.73 (O-phospho-L-seryl-tRNA: Cys-tRNA synthase) converts the produced O-phospho-L-seryl-tRNACys to Cys-tRNACys. The SepRS/SepCysS pathway is the sole route for cysteine biosynthesis in the organism [1]. Methanosarcina mazei can use both pathways, the direct route using EC 6.1.1.16 (cysteine---tRNA ligase) and the indirect pathway with EC 6.1.1.27 and EC 2.5.1.73 (O-phospho-L-seryl-tRNA: Cys-tRNA synthase) [2].